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miRNA, lncRNA and circRNA: targeted molecules with therapeutic promises in Mycoplasma pneumoniae infection

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Abstract

Mycoplasma pneumoniae (MP) is primarily recognized as a respiratory pathogen that causes community-acquired pneumonia, which can lead to acute upper and lower airway inflammation and extrapulmonary syndrome. Refractory pneumonia caused by MP can cause severe complications and even be life-threatening, particularly in infants and the elderly. It is well-known that non-coding RNAs (ncRNAs) represented by miRNAs, lncRNAs and circRNAs have been manifested to be widely involved in the regulation of gene expression. Growing evidence indicates that these ncRNAs have distinct differentiated expression in MP infection and affect multiple biological processes, playing an indispensable role in the initiation and promotion of MP infection. However, the epigenetic mechanisms involved in the development of MP infection remain unclear. This article reviews the mechanisms by which miRNAs, lncRNAs, and circRNAs mediate MP infection, such as inflammatory responses, apoptosis and pulmonary fibrosis. Focusing on miRNAs, lncRNAs and circRNAs associated with MP infection could provide new insights into this disease’s early diagnosis and therapeutic approaches.

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Abbreviations

MP:

Mycoplasma pneumoniae

MPP:

Mycoplasma pneumoniae pneumonia

ncRNAs:

Non-coding RNAs

miRNAs:

MicroRNAs

lncRNAs:

Long non-coding RNAs

circRNA:

Circular RNA

CAP:

Community-acquired pneumonia

CARDS:

Community-acquired respiratory distress syndrome

EVs:

Extracellular vesicles

ADP:

Adenosine diphosphate

UTR:

Untranslated region

TLR:

4: Toll-like receptor 4

MyD88:

Myeloid differentiation factor 88

IL:

Interleukin

TNF:

Tumor necrosis factor

PBMCs:

Peripheral blood mononuclear cells

NSCLC:

Non-small-cell lung cancer

ceRNA:

Competitive endogenous RNA

ASO:

Antisense oligonucleotide

siRNA:

Small interfering RNA

shRNA:

Short hairpin RNA

References

  • Andersen GB, Tost J (2020) Circulating miRNAs as biomarker in cancer. Recent Results Cancer Res 215:277–298

    Article  CAS  PubMed  Google Scholar 

  • Andjus P, Kosanovic M, Milicevic K, Gautam M, Vainio SJ, Jagecic D, Kozlova EN, Pivoriunas A, Chachques JC, Sakaj M, Brunello G, Mitrecic D, Zavan B (2020) Extracellular vesicles as innovative tool for diagnosis, regeneration and protection against neurological damage. Int J Mol Sci 21(18):6859

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bai S, Wang W, Ye L, Fang L, Dong T, Zhang R, Wang X, Gao H, Shen B, Ding S (2021) IL-17 stimulates neutrophils to release S100A8/A9 to promote lung epithelial cell apoptosis in mycoplasma pneumoniae-induced pneumonia in children. Biomed Pharmacother 143:112184

    Article  CAS  PubMed  Google Scholar 

  • Bajantri B, Venkatram S, Diaz-Fuentes G (2018) Mycoplasma pneumoniae: a potentially severe infection. J Clin Med Res 10(7):535–544

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Balasubramanian S, Pandranki L, Maupin S, Ramasamy K, Taylor AB, Hart PJ, Baseman JB, Kannan TR (2019) Disulfide bond of mycoplasma pneumoniae community-acquired respiratory distress syndrome toxin is essential to maintain the ADP-ribosylating and vacuolating activities. Cell Microbiol 21(8):e13032

    Article  PubMed  PubMed Central  Google Scholar 

  • Barnabei L, Laplantine E, Mbongo W, Rieux-Laucat F, Weil R (2021) NF-kappaB: at the borders of autoimmunity and inflammation. Front Immunol 12:716469

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bayraktar E, Bayraktar R, Oztatlici H, Lopez-Berestein G, Amero P, Rodriguez-Aguayo C (2023) Targeting miRNAs and other non-coding RNAs as a therapeutic approach: an update. Noncoding RNA 9(2):27

    CAS  PubMed  PubMed Central  Google Scholar 

  • Benz F, Roy S, Trautwein C, Roderburg C, Luedde T (2016) Circulating MicroRNAs as biomarkers for sepsis. Int J Mol Sci 17(1):78

    Article  PubMed  PubMed Central  Google Scholar 

  • Bi Y, Zhu Y, Ma X, Xu J, Guo Y, Huang T, Zhang S, Wang X, Zhao D, Liu F (2021) Development of a scale for early prediction of refractory mycoplasma pneumoniae pneumonia in hospitalized children. Sci Rep 11(1):6595

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Botti G, Giordano A, Feroce F, De Chiara AR, Cantile M (2019) Noncoding RNAs as circulating biomarkers in osteosarcoma patients. J Cell Physiol 234(11):19249–19255

    Article  CAS  PubMed  Google Scholar 

  • Cai F, Shou X, Ye Q (2022) Epidemiological study on mycoplasma pneumoniae and chlamydia pneumoniae infection of hospitalized children in a single center during the COVID-19 pandemic. Front Cell Infect Microbiol 12:843463

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cao C, Yin C, Shou S, Wang J, Yu L, Li X, Chai Y (2018) Ulinastatin protects against LPS-induced acute lung injury by attenuating TLR4/NF-kappaB pathway activation and reducing inflammatory mediators. Shock 50(5):595–605

    Article  CAS  PubMed  Google Scholar 

  • Chan JJ, Tay Y (2018) Noncoding RNA:RNA regulatory networks in cancer. Int J Mol Sci 19(5):1310

    Article  PubMed  PubMed Central  Google Scholar 

  • Chaudhry R, Ghosh A, Chandolia A (2016) Pathogenesis of mycoplasma pneumoniae: an update. Indian J Med Microbiol 34(1):7–16

    Article  CAS  PubMed  Google Scholar 

  • Chen X, Liu F, Zheng B, Kang X, Wang X, Mou W, Zhang H, Jiao A, Zhao S, Gui J (2021a) Exhausted and apoptotic BALF T cells in proinflammatory airway milieu at acute phase of severe mycoplasma pneumoniae pneumonia in children. Front Immunol 12:760488

    Article  CAS  PubMed  Google Scholar 

  • Chen P, Huang Z, Chen L, Zhuang S, Lin H, Xie J, Zheng K (2021b) The relationships between LncRNA NNT-AS1, CRP, PCT and their interactions and the refractory mycoplasma pneumoniae pneumonia in children. Sci Rep 11(1):2059

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chen J, Zhang J, Lu Z, Chen Y, Huang S, Li H, Lin S, Yu J, Zeng X, Ji C, Zheng Y, Dai F, Dong W, Xu H, Chen W, Jin X, Cui Z, Qiao J, Qin W, Chen H, Jiang W, Zhang X, Song J, Shao J, Su W, Wang C, Liu F, Zhao Y, Zou Y, Guo R, Zhang L, Wu J, Yuan S, Tang M, Wu Y, Lin J, Dong W, Chen X, Sun X, Yin Y (2022a) Mycoplasma pneumoniae among Chinese outpatient children with mild respiratory tract infections during the Coronavirus Disease 2019 pandemic. Microbiol Spectr 10(1):e0155021

    Article  PubMed  Google Scholar 

  • Chen Y, Zhang W, Xin L, Wang Z, Zheng M, Vijayalakshmi A (2022b) Modulatory apoptotic effects of sinomenine on mycoplasma pneumonia through the attenuation of inflammation via ERK/JNK/NF-κB signaling pathway. Arch Microbiol 204(7):441

    Article  CAS  PubMed  Google Scholar 

  • Chen B, Dragomir MP, Yang C, Li Q, Horst D, Calin GA (2022c) Targeting non-coding RNAs to overcome cancer therapy resistance. Signal Transduct Target Ther 7(1):121

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cheng Y, Su Y, Wang S, Liu Y, Jin L, Wan Q, Liu Y, Li C, Sang X, Yang L, Liu C, Wang Z (2020) Identification of circRNA-lncRNA-miRNA-mRNA competitive endogenous RNA network as novel prognostic markers for acute myeloid leukemia. Genes (basel) 11(8):868

    Article  CAS  PubMed  Google Scholar 

  • Chu C, Lei X, Li Y, Luo Y, Ding Y, Zhou W, Ji W (2019) High expression of miR-222-3p in children with mycoplasma pneumoniae pneumonia. Ital J Pediatr 45(1):163

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Condrat CE, Thompson DC, Barbu MG, Bugnar OL, Boboc A, Cretoiu D, Suciu N, Cretoiu SM, Voinea SC (2020) miRNAs as biomarkers in disease: latest findings regarding their role in diagnosis and prognosis. Cells 9(2):276

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Contreras J, Rao DS (2012) MicroRNAs in inflammation and immune responses. Leukemia 26(3):404–413

    Article  CAS  PubMed  Google Scholar 

  • Correia de Sousa M, Gjorgjieva M, Dolicka D, Sobolewski C, Foti M (2019) Deciphering miRNAs’ action through miRNA editing. Int J Mol Sci 20(24):6249

    Article  PubMed  PubMed Central  Google Scholar 

  • Curtis HJ, Sibley CR, Wood MJ (2012) Mirtrons, an emerging class of atypical miRNA. Wiley Interdiscip Rev RNA 3(5):617–632

    Article  CAS  PubMed  Google Scholar 

  • Dai W, Wang H, Zhou Q, Feng X, Lu Z, Li D, Yang Z, Liu Y, Li Y, Xie G, Shen K, Yang Y, Zheng Y, Li S (2018) The concordance between upper and lower respiratory microbiota in children with mycoplasma pneumoniae pneumonia. Emerg Microbes Infect 7(1):92

    Article  PubMed  PubMed Central  Google Scholar 

  • D’Alonzo R, Mencaroni E, Di Genova L, Laino D, Principi N, Esposito S (2018) Pathogenesis and treatment of neurologic diseases associated with mycoplasma pneumoniae infection. Front Microbiol 9:2751

    Article  PubMed  PubMed Central  Google Scholar 

  • De Guire V, Robitaille R, Tetreault N, Guerin R, Menard C, Bambace N, Sapieha P (2013) Circulating miRNAs as sensitive and specific biomarkers for the diagnosis and monitoring of human diseases: promises and challenges. Clin Biochem 46(10–11):846–860

    Article  PubMed  Google Scholar 

  • Dzakah EE, Huang L, Xue Y, Wei S, Wang X, Chen H, Shui J, Kyei F, Rashid F, Zheng H, Yang B, Tang S (2021) Host cell response and distinct gene expression profiles at different stages of Chlamydia trachomatis infection reveals stage-specific biomarkers of infection. BMC Microbiol 21(1):3

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fan H, Lu B, Yang D, Zhang D, Shi T, Lu G (2019) Distribution and expression of IL-17 and related cytokines in children with mycoplasma pneumoniae pneumonia. Jpn J Infect Dis 72(6):387–393

    Article  CAS  PubMed  Google Scholar 

  • Fasolo F, Di Gregoli K, Maegdefessel L, Johnson JL (2019) Non-coding RNAs in cardiovascular cell biology and atherosclerosis. Cardiovasc Res 115(12):1732–1756

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Feng M, Schaff AC, Balish MF (2020) Mycoplasma pneumoniae biofilms grown in vitro: traits associated with persistence and cytotoxicity. Microbiology (reading) 166(7):629–640

    Article  CAS  PubMed  Google Scholar 

  • Fu X, Li Y, Zhang Z, Wang B, Wei R, Chu C, Xu K, Li L, Liu Y, Li X (2023) Emerging role of miRNAs, lncRNAs, and circRNAs in pregnancy-associated diseases. Chin Med J (engl) 136(11):1300–1310

    Article  PubMed  Google Scholar 

  • Ganjali M, Kheirkhah B, Amini K (2021) Expression of miRNA-601 and PD-L1 among iranian patients with lung cancer and their relationship with smoking and mycoplasma infection. Cell J 23(7):723–729

    PubMed  PubMed Central  Google Scholar 

  • Garcia-Martin R, Wang G, Brandao BB, Zanotto TM, Shah S, Kumar Patel S, Schilling B, Kahn CR (2022) MicroRNA sequence codes for small extracellular vesicle release and cellular retention. Nature 601(7893):446–451

    Article  CAS  PubMed  Google Scholar 

  • Germolec DR, Shipkowski KA, Frawley RP, Evans E (1803) Markers of inflammation. Methods Mol Biol 2018:57–79

    Google Scholar 

  • Gu H, Zhu Y, Zhou Y, Huang T, Zhang S, Zhao D, Liu F (2020) LncRNA MALAT1 affects mycoplasma pneumoniae pneumonia via NF-kappaB regulation. Front Cell Dev Biol 8:563693

    Article  PubMed  PubMed Central  Google Scholar 

  • Gu H, Song J, Chen Y, Wang Y, Tan X, Zhao H (2022) Inflammation-related LncRNAs signature for prognosis and immune response evaluation in uterine corpus endometrial carcinoma. Front Oncol 12:923641

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Han T, Jing X, Bao J, Zhao L, Zhang A, Miao R, Guo H, Zhou B, Zhang S, Sun J, Shi J (2020) H. pylori infection alters repair of DNA double-strand breaks via SNHG17. J Clin Invest 130(7):3901–3918

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Han JJ, Wang XQ, Zhang XA (2022) Functional interactions between lncRNAs/circRNAs and miRNAs: insights into rheumatoid arthritis. Front Immunol 13:810317

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hao Y, Kuang Z, Jing J, Miao J, Mei LY, Lee RJ, Kim S, Choe S, Krause DC, Lau GW (2014) Mycoplasma pneumoniae modulates STAT3-STAT6/EGFR-FOXA2 signaling to induce overexpression of airway mucins. Infect Immun 82(12):5246–5255

    Article  PubMed  PubMed Central  Google Scholar 

  • Hsieh YC, Li SW, Chen YY, Kuo CC, Chen YC, Chang IY, Pan YJ, Li TH, Chiang RL, Huang YY, Liao WC (2022) Global genome diversity and recombination in mycoplasma pneumoniae. Emerg Infect Dis 28(1):111–117

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hu W, Liu C, Bi ZY, Zhou Q, Zhang H, Li LL, Zhang J, Zhu W, Song YY, Zhang F, Yang HM, Bi YY, He QQ, Tan GJ, Sun CC, Li DJ (2020) Comprehensive landscape of extracellular vesicle-derived RNAs in cancer initiation, progression, metastasis and cancer immunology. Mol Cancer 19(1):102

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Huang S, Li JY, Wu J, Meng L, Shou CC (2001) Mycoplasma infections and different human carcinomas. World J Gastroenterol 7(2):266–269

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Huang F, Fan H, Yang D, Zhang J, Shi T, Zhang D, Lu G (2021) Ribosomal RNAdepleted RNA sequencing reveals the pathogenesis of refractory Mycoplasma pneumoniae pneumonia in children. Mol Med Rep 24(5):761

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jain S, Williams DJ, Arnold SR, Ampofo K, Bramley AM, Reed C, Stockmann C, Anderson EJ, Grijalva CG, Self WH, Zhu Y, Patel A, Hymas W, Chappell JD, Kaufman RA, Kan JH, Dansie D, Lenny N, Hillyard DR, Haynes LM, Levine M, Lindstrom S, Winchell JM, Katz JM, Erdman D, Schneider E, Hicks LA, Wunderink RG, Edwards KM, Pavia AT, McCullers JA, Finelli L, C.E.S. Team (2015a) Community-acquired pneumonia requiring hospitalization among US children. N Engl J Med 372(9):835–845

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jain S, Self WH, Wunderink RG, Fakhran S, Balk R, Bramley AM, Reed C, Grijalva CG, Anderson EJ, Courtney DM, Chappell JD, Qi C, Hart EM, Carroll F, Trabue C, Donnelly HK, Williams DJ, Zhu Y, Arnold SR, Ampofo K, Waterer GW, Levine M, Lindstrom S, Winchell JM, Katz JM, Erdman D, Schneider E, Hicks LA, McCullers JA, Pavia AT, Edwards KM, Finelli L, C.E.S. Team (2015b) Community-acquired pneumonia requiring hospitalization among US adults. N Engl J Med 373(5):415–427

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jathar S, Kumar V, Srivastava J, Tripathi V (2017) Technological developments in lncRNA Biology. Adv Exp Med Biol 1008:283–323

    Article  CAS  PubMed  Google Scholar 

  • Jia Z, Sun Q, Zheng Y, Xu J, Wang Y (2023) The immunogenic involvement of miRNA-492 in mycoplasma pneumoniae infection in pediatric patients. J Pediatr (rio J) 99(2):187–192

    Article  PubMed  Google Scholar 

  • Jiang X, Lei R (2023) Extracellular lncRNAs secreted and absorbed by cardiomyocytes. J Cell Biochem 124(6):785–796

    Article  CAS  PubMed  Google Scholar 

  • Jiang K, Yang J, Yang C, Zhang T, Shaukat A, Yang X, Dai A, Wu H, Deng G (2020) miR-148a suppresses inflammation in lipopolysaccharide-induced endometritis. J Cell Mol Med 24(1):405–417

    Article  CAS  PubMed  Google Scholar 

  • Jiang Z, Li S, Zhu C, Zhou R, Leung PHM (2021) Mycoplasma pneumoniae Infections: pathogenesis and vaccine development. Pathogens 10(2):119

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jimenez A, De Jesus-Rojas W (2021) Mycoplasma pneumoniae and bronchiolitis obliterans: how a common organism leads to a rare pulmonary disease in pediatrics. Cureus 13(8):e17193

    PubMed  PubMed Central  Google Scholar 

  • Jimi E, Fei H, Nakatomi C (2019) NF-kappaB signaling regulates physiological and pathological chondrogenesis. Int J Mol Sci 20(24):6275

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kalem MC, Panepinto JC (2022) Long non-coding RNAs in cryptococcus neoformans: insights into fungal pathogenesis. Front Cell Infect Microbiol 12:858317

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kim SH, Lee E, Song ES, Lee YY (2021) Clinical significance of pleural effusion in mycoplasma pneumoniae pneumonia in children. Pathogens 10(9):1075

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Krafft C, Christy C (2020) Mycoplasma pneumonia in children and adolescents. Pediatr Rev 41(1):12–19

    Article  PubMed  Google Scholar 

  • Krause DC, Chen S, Shi J, Jensen AJ, Sheppard ES, Jensen GJ (2018) Electron cryotomography of Mycoplasma pneumoniae mutants correlates terminal organelle architectural features and function. Mol Microbiol 108(3):306–318

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kristensen LS, Andersen MS, Stagsted LVW, Ebbesen KK, Hansen TB, Kjems J (2019) The biogenesis, biology and characterization of circular RNAs. Nat Rev Genet 20(11):675–691

    Article  CAS  PubMed  Google Scholar 

  • Kristensen LS, Jakobsen T, Hager H, Kjems J (2022) The emerging roles of circRNAs in cancer and oncology. Nat Rev Clin Oncol 19(3):188–206

    Article  CAS  PubMed  Google Scholar 

  • Kumar S (2018) Mycoplasma pneumoniae: a significant but underrated pathogen in paediatric community-acquired lower respiratory tract infections. Indian J Med Res 147(1):23–31

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kutty PK, Jain S, Taylor TH, Bramley AM, Diaz MH, Ampofo K, Arnold SR, Williams DJ, Edwards KM, McCullers JA, Pavia AT, Winchell JM, Schrag SJ, Hicks LA (2019) Mycoplasma pneumoniae among children hospitalized with community-acquired pneumonia. Clin Infect Dis 68(1):5–12

    CAS  PubMed  Google Scholar 

  • Lai XN, Li J, Tang LB, Chen WT, Zhang L, Xiong LX (2020) MiRNAs and LncRNAs: dual roles in TGF-beta signaling-regulated metastasis in lung cancer. Int J Mol Sci 21(4):1193

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Li Y (2021) Modern epigenetics methods in biological research. Methods 187:104–113

    Article  CAS  PubMed  Google Scholar 

  • Li X, Yang L, Chen LL (2018) The biogenesis, functions, and challenges of circular RNAs. Mol Cell 71(3):428–442

    Article  CAS  PubMed  Google Scholar 

  • Li QL, Wu YY, Sun HM, Gu WJ, Zhang XX, Wang MJ, Yan YD, Hao CL, Ji W, Chen ZR (2019a) The role of miR-29c/B7-H3/Th17 axis in children with mycoplasma pneumoniae pneumonia. Ital J Pediatr 45(1):61

    Article  PubMed  PubMed Central  Google Scholar 

  • Li HN, Zhao X, Zha YJ, Du F, Liu J, Sun L (2019b) miR146a5p suppresses ATPbinding cassette subfamily G member 1 dysregulation in patients with refractory Mycoplasma pneumoniae via interleukin 1 receptorassociated kinase 1 downregulation. Int J Mol Med 44(6):2003–2014

    CAS  PubMed  PubMed Central  Google Scholar 

  • Li J, Sun D, Pu W, Wang J, Peng Y (2020a) Circular RNAs in cancer: biogenesis, function, and clinical significance, trends. Cancer 6(4):319–336

    CAS  Google Scholar 

  • Li D, Zhang J, Li J (2020b) Role of miRNA sponges in hepatocellular carcinoma. Clin Chim Acta 500:10–19

    Article  CAS  PubMed  Google Scholar 

  • Li H, Lian K, Mao J, Huang F, Zhang C, Zang J (2022a) 2020a LncRNA LEMD1-AS1 relieves chondrocyte inflammation by targeting miR-944/PGAP1 in osteoarthritis. Cell Cycle 10(1080/15384101):2084294

    Google Scholar 

  • Li X, Zhang S, Zhang S, Kuang W, Tang C (2022b) Inflammatory response-related long non-coding RNA Signature predicts the prognosis of hepatocellular carcinoma. J Oncol 2022:9917244

    PubMed  PubMed Central  Google Scholar 

  • Li R, Xu H, Gao X (2023a) The ceRNA network regulates epithelial-mesenchymal transition in colorectal cancer. Heliyon 9(3):e14143

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Li K, Yao T, Wang Z (2023b) lncRNA-mediated ceRNA network in bladder cancer. Noncoding RNA Res 8(2):135–145

    Article  CAS  PubMed  Google Scholar 

  • Liang Y, Liu N, Yang L, Tang J, Wang Y, Mei M (2021) A brief review of circRNA biogenesis, detection, and function. Curr Genomics 22(7):485–495

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lin Y, Tan D, Kan Q, Xiao Z, Jiang Z (2018) The protective effect of naringenin on airway remodeling after mycoplasma pneumoniae infection by inhibiting autophagy-mediated lung inflammation and fibrosis. Mediators Inflamm 2018:8753894

    Article  PubMed  PubMed Central  Google Scholar 

  • Ling H, Fabbri M, Calin GA (2013) MicroRNAs and other non-coding RNAs as targets for anticancer drug development. Nat Rev Drug Discov 12(11):847–865

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Liu CX, Chen LL (2022) Circular RNAs: characterization, cellular roles, and applications. Cell 185(12):2016–2034

    Article  CAS  PubMed  Google Scholar 

  • Liu F, Liu T, Sun M, Zhou J, Xue F, Chen S, Chen J, Zhang L (2021a) Maxing shigan decoction mitigates mycoplasma pneumonia-induced pyroptosis in A549 cells via the NLRP3 inflammasome. Infect Drug Resist 14:859–867

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Liu Y, Nie H, Ding Y, Hou Y, Mao K, Cui Y (2021b) MiRNA, a new treatment strategy for pulmonary fibrosis. Curr Drug Targets 22(7):793–802

    CAS  PubMed  Google Scholar 

  • Loconsole D, De Robertis AL, Sallustio A, Centrone F, Morcavallo C, Campanella S, Accogli M, Chironna M (2021) Update on the epidemiology of macrolide-resistant mycoplasma pneumoniae in Europe: a systematic review. Infect Dis Rep 13(3):811–820

    Article  PubMed  PubMed Central  Google Scholar 

  • Loens K, Ieven M (2016) Mycoplasma pneumoniae: current knowledge on nucleic acid amplification techniques and serological diagnostics. Front Microbiol 7:448

    Article  PubMed  PubMed Central  Google Scholar 

  • Lorenzo H, Quesada O, Assuncao P, Castro A, Rodriguez F (2006) Cytokine expression in porcine lungs experimentally infected with mycoplasma hyopneumoniae. Vet Immunol Immunopathol 109(3–4):199–207

    Article  CAS  PubMed  Google Scholar 

  • Lou Z, Zhou R, Su Y, Liu C, Ruan W, Jeon CO, Han X, Lin C, Jia B (2021) Minor and major circRNAs in virus and host genomes. J Microbiol 59(3):324–331

    Article  CAS  PubMed  Google Scholar 

  • Lu Y, Wang Y, Hao C, Ji W, Chen Z, Jiang W, Yan Y, Gu W (2018) Clinical characteristics of pneumonia caused by mycoplasma pneumoniae in children of different ages. Int J Clin Exp Pathol 11(2):855–861

    PubMed  PubMed Central  Google Scholar 

  • Lu S, Zhu N, Guo W, Wang X, Li K, Yan J, Jiang C, Han S, Xiang H, Wu X, Liu Y, Xiong H, Chen L, Gong Z, Luo F, Hou W (2020) RNA-seq revealed a circular RNA-microRNA-mRNA regulatory network in hantaan virus infection. Front Cell Infect Microbiol 10:97

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Maeki M, Uno S, Niwa A, Okada Y, Tokeshi M (2022) Microfluidic technologies and devices for lipid nanoparticle-based RNA delivery. J Control Release 344:80–96

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Makarova JA, Shkurnikov MU, Turchinovich AA, Tonevitsky AG, Grigoriev AI (2015) Circulating microRNAs. Biochemistry (mosc) 80(9):1117–1126

    Article  CAS  PubMed  Google Scholar 

  • Matsuda M, Huh Y, Ji RR (2019) Roles of inflammation, neurogenic inflammation, and neuroinflammation in pain. J Anesth 33(1):131–139

    Article  PubMed  Google Scholar 

  • Mehta SL, Chokkalla AK, Vemuganti R (2021) Noncoding RNA crosstalk in brain health and diseases. Neurochem Int 149:105139

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Meyer-Junco L (2016) Role of atypical bacteria in hospitalized patients with nursing home-acquired pneumonia. Hosp Pharm 51(9):768–777

    Article  PubMed  PubMed Central  Google Scholar 

  • Meyer Sauteur PM, Panisova E, Seiler M, Theiler M, Berger C, Dumke R (2021) Mycoplasma pneumoniae genotypes and clinical outcome in children. J Clin Microbiol 59(7):e0074821

    Article  PubMed  Google Scholar 

  • Miller M, Hanna N (2021) Advances in systemic therapy for non-small cell lung cancer. BMJ 375:n2363

    Article  PubMed  Google Scholar 

  • Mirijello A, La Marca A, D’Errico MM, Curci S, Vendemiale G, Grandone E, De Cosmo S (2020) Venous thromboembolism during mycoplasma pneumoniae infection: case report and review of the literature. Eur Rev Med Pharmacol Sci 24(19):10061–10068

    CAS  PubMed  Google Scholar 

  • Miyashita N, Nakamori Y, Ogata M, Fukuda N, Yamura A, Ishiura Y, Nomura S (2022) Clinical differences between community-acquired mycoplasma pneumoniae pneumonia and COVID-19 pneumonia. J Clin Med 11(4):964

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mohanapriya R, Akshaya RL, Selvamurugan N (2022) A regulatory role of circRNA-miRNA-mRNA network in osteoblast differentiation. Biochimie 193:137–147

    Article  CAS  PubMed  Google Scholar 

  • Narita M (2009) Pathogenesis of neurologic manifestations of mycoplasma pneumoniae infection. Pediatr Neurol 41(3):159–166

    Article  PubMed  Google Scholar 

  • Narita M (2010) Pathogenesis of extrapulmonary manifestations of mycoplasma pneumoniae infection with special reference to pneumonia. J Infect Chemother 16(3):162–169

    Article  PubMed  Google Scholar 

  • Nejad C, Stunden HJ, Gantier MP (2018) A guide to miRNAs in inflammation and innate immune responses. FEBS J 285(20):3695–3716

    Article  CAS  PubMed  Google Scholar 

  • Nojima T, Proudfoot NJ (2022) Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics. Nat Rev Mol Cell Biol 23(6):389–406

    Article  CAS  PubMed  Google Scholar 

  • Nooreldeen R, Bach H (2021) Current and future development in lung cancer diagnosis. Int J Mol Sci 22(16):8661

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Oishi T, Fukuda Y, Wakabayashi S, Kono M, Ono S, Kato A, Kondo E, Nakamura Y, Tanaka Y, Teranishi H, Akaike H, Tanaka T, Miyata I, Ogita S, Ohno N, Nakano T, Ouchi K (2020) Low prevalence of chlamydia pneumoniae infections during the mycoplasma pneumoniae epidemic season: results of nationwide surveillance in Japan. J Infect Chemother 26(11):1116–1121

    Article  CAS  PubMed  Google Scholar 

  • Omae T, Matsubayashi T (2015) Lung abscess caused by Mycoplasma pneumoniae. Pediatr Int 57(4):773–775

    Article  PubMed  Google Scholar 

  • Onozuka D, Hashizume M, Hagihara A (2009) Impact of weather factors on mycoplasma pneumoniae pneumonia. Thorax 64(6):507–511

    Article  CAS  PubMed  Google Scholar 

  • Peng Y, Chen Z, Li Y, Lu Q, Li H, Han Y, Sun D, Li X (2022) Combined therapy of Xiaoer Feire Kechuan oral liquid and azithromycin for mycoplasma pneumoniae pneumonia in children: a systematic review & meta-analysis. Phytomedicine 96:153899

    Article  CAS  PubMed  Google Scholar 

  • Petkovic S, Muller S (2015) RNA circularization strategies in vivo and in vitro. Nucleic Acids Res 43(4):2454–2465

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pittet LF, Bertelli C, Scherz V, Rochat I, Mardegan C, Brouillet R, Jaton K, Mornand A, Kaiser L, Posfay-Barbe K, Asner SA, Greub G (2021) Chlamydia pneumoniae and mycoplasma pneumoniae in children with cystic fibrosis: impact on bacterial respiratory microbiota diversity. Pathog Dis 79(1):ftaa074.https://doi.org/10.1093/femspd/ftaa074

    Article  CAS  PubMed  Google Scholar 

  • Qian X, Xiao Q, Li Z (2021) Tectorigenin regulates migration, invasion, and apoptosis in dexamethasone-induced human airway epithelial cells through up-regulating miR-222-3p. Drug Dev Res 82(7):959–968

    Article  CAS  PubMed  Google Scholar 

  • Ramasamy K, Balasubramanian S, Manickam K, Pandranki L, Taylor AB, Hart PJ, Baseman JB, Kannan TR (2018) Mycoplasma pneumoniae community-acquired respiratory distress syndrome toxin uses a novel KELED sequence for retrograde transport and subsequent cytotoxicity. Mbio 9(1):e01663–17. https://doi.org/10.1128/mBio.01663-17

    Article  PubMed  PubMed Central  Google Scholar 

  • Reese M, Dhayat SA (2021) Small extracellular vesicle non-coding RNAs in pancreatic cancer: molecular mechanisms and clinical implications. J Hematol Oncol 14(1):141

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rodman Berlot J, Krivec U, Praprotnik M, Mrvic T, Kogoj R, Kese D (2018) Clinical characteristics of infections caused by mycoplasma pneumoniae P1 genotypes in children. Eur J Clin Microbiol Infect Dis 37(7):1265–1272

    Article  PubMed  Google Scholar 

  • Rogers MB (2011) Mycoplasma and cancer: in search of the link. Oncotarget 2(4):271–273

    Article  PubMed  PubMed Central  Google Scholar 

  • Rothstein TE, Cunningham SA, Rieke RA, Mainella JM, Mutchler MM, Patel R (2022) Macrolide resistance in mycoplasma pneumoniae, Midwestern United States, 2014 to 2021. Antimicrob Agents Chemother 66(4):e0243221

    Article  PubMed  Google Scholar 

  • Salim U, Kumar A, Kulshreshtha R, Vivekanandan P (2022) Biogenesis, characterization, and functions of mirtrons. Wiley Interdiscip Rev RNA 13(1):e1680

    Article  CAS  PubMed  Google Scholar 

  • Saliminejad K, Khorram Khorshid HR, Soleymani Fard S, Ghaffari SH (2019) An overview of microRNAs: biology, functions, therapeutics, and analysis methods. J Cell Physiol 234(5):5451–5465

    Article  CAS  PubMed  Google Scholar 

  • Samad AFA, Kamaroddin MF (2023) Innovative approaches in transforming microRNAs into therapeutic tools. Wiley Interdiscip Rev RNA 14(1):e1768

    Article  CAS  PubMed  Google Scholar 

  • Sand M (2014) The pathway of miRNA maturation. Methods Mol Biol 1095:3–10

    Article  CAS  PubMed  Google Scholar 

  • Saraya T (2016) The history of mycoplasma pneumoniae pneumonia. Front Microbiol 7:364

    Article  PubMed  PubMed Central  Google Scholar 

  • Segovia JA, Chang TH, Winter VT, Coalson JJ, Cagle MP, Pandranki L, Bose S, Baseman JB, Kannan TR (2018) NLRP3 is a critical regulator of inflammation and innate immune cell response during mycoplasma pneumoniae infection. Infect Immun 86(1):e00548–17. https://doi.org/10.1128/IAI.00548-17

    Article  PubMed  Google Scholar 

  • Sharma AR, Sharma G, Bhattacharya M, Lee SS, Chakraborty C (2022) Circulating miRNA in atherosclerosis: a clinical biomarker and early diagnostic tool. Curr Mol Med 22(3):250–262

    Article  CAS  PubMed  Google Scholar 

  • Singh RP, Massachi I, Manickavel S, Singh S, Rao NP, Hasan S, Mc Curdy DK, Sharma S, Wong D, Hahn BH, Rehimi H (2013) The role of miRNA in inflammation and autoimmunity. Autoimmun Rev 12(12):1160–1165

    Article  CAS  PubMed  Google Scholar 

  • Smolarz B, Durczynski A, Romanowicz H, Szyllo K, Hogendorf P (2022) miRNAs in cancer (Review of Literature). Int J Mol Sci 23(5):2805

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Soleimani A, Rahmani F, Ferns GA, Ryzhikov M, Avan A, Hassanian SM (2020) Role of the NF-kappaB signaling pathway in the pathogenesis of colorectal cancer. Gene 726:144132

    Article  CAS  PubMed  Google Scholar 

  • Su X, You X, Luo H, Liang K, Chen L, Tian W, Ye Z, He J (2021) Community-acquired respiratory distress syndrome toxin: unique exotoxin for M. pneumoniae. Front Microbiol 12:766591

    Article  PubMed  PubMed Central  Google Scholar 

  • Suster I, Feng Y (2021) Multifaceted Regulation of MicroRNA Biogenesis: Essential Roles and Functional Integration in Neuronal and Glial Development. Int J Mol Sci 22(13):6765

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Suzuki Y, Seto J, Shimotai Y, Itagaki T, Katsushima Y, Katsushima F, Ikeda T, Mizuta K, Hongo S, Matsuzaki Y (2019) Polyclonal spread of multiple genotypes of mycoplasma pneumoniae in semi-closed settings in Yamagata. Japan, J Med Microbiol 68(5):785–790

    Article  PubMed  Google Scholar 

  • Tafrihi M, Hasheminasab E (2019) MiRNAs: biology biogenesis, their web-based tools, and databases. Microrna 8(1):4–27

    Article  CAS  PubMed  Google Scholar 

  • Tamiya S, Yoshikawa E, Ogura M, Kuroda E, Suzuki K, Yoshioka Y (2021) Neutrophil-mediated lung injury both via TLR2-dependent production of IL-1alpha and IL-12 p40, and TLR2-independent CARDS toxin after mycoplasma pneumoniae infection in mice. Microbiol Spectr 9(3):e0158821

    Article  PubMed  Google Scholar 

  • Tang J, Li Y, Wang J, Wu Q, Yan H (2019) Polydatin suppresses the development of lung inflammation and fibrosis by inhibiting activation of the NACHT domain-, leucine-rich repeat-, and pyd-containing protein 3 inflammasome and the nuclear factor-kappaB pathway after Mycoplasma pneumoniae infection. J Cell Biochem 120(6):10137–10144

    Article  CAS  PubMed  Google Scholar 

  • Terrinoni A, Calabrese C, Basso D, Aita A, Caporali S, Plebani M, Bernardini S (2019) The circulating miRNAs as diagnostic and prognostic markers. Clin Chem Lab Med 57(7):932–953

    Article  CAS  PubMed  Google Scholar 

  • Tian DD, Jiang R, Chen XJ, Ye Q (2017) Meteorological factors on the incidence of MP and RSV pneumonia in children. PLoS ONE 12(3):e0173409

    Article  PubMed  PubMed Central  Google Scholar 

  • Tong L, Hao H, Zhang Z, Lv Y, Liang X, Liu Q, Liu T, Gong P, Zhang L, Cao F, Pastorin G, Lee CN, Chen X, Wang JW, Yi H (2021) Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota. Theranostics 11(17):8570–8586

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tong L, Huang S, Zheng C, Zhang Y, Chen Z (2022) Refractory mycoplasma pneumoniae pneumonia in children: early recognition and management. J Clin Med 11(10):2824

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tsai TA, Tsai CK, Kuo KC, Yu HR (2021) Rational stepwise approach for mycoplasma pneumoniae pneumonia in children. J Microbiol Immunol Infect 54(4):557–565

    Article  CAS  PubMed  Google Scholar 

  • Unni PA, Ali A, Rout M, Thabitha A, Vino S, Lulu SS (2019) Designing of an epitope-based peptide vaccine against walking pneumonia: an immunoinformatics approach. Mol Biol Rep 46(1):511–527

    Article  CAS  PubMed  Google Scholar 

  • Virga F, Cappellesso F, Stijlemans B, Henze AT, Trotta R, Van Audenaerde J, Mirchandani AS, Sanchez-Garcia MA, Vandewalle J, Orso F, Riera-Domingo C, Griffa A, Ivan C, Smits E, Laoui D, Martelli F, Langouche L, Van den Berghe G, Feron O, Ghesquiere B, Prenen H, Libert C, Walmsley SR, Corbet C, Van Ginderachter JA, Ivan M, Taverna D, Mazzone M (2021) Macrophage miR-210 induction and metabolic reprogramming in response to pathogen interaction boost life-threatening inflammation. Sci Adv 7(19):eabf0466. https://doi.org/10.1126/sciadv.abf0466

    Article  CAS  PubMed  Google Scholar 

  • Vishnoi A, Rani S (2017) MiRNA biogenesis and regulation of diseases: an overview. Methods Mol Biol 1509:1–10

    Article  CAS  PubMed  Google Scholar 

  • Vrabel D, Pour L, Sevcikova S (2019) The impact of NF-kappaB signaling on pathogenesis and current treatment strategies in multiple myeloma. Blood Rev 34:56–66

    Article  CAS  PubMed  Google Scholar 

  • Waites KB, Ratliff A, Crabb DM, Xiao L, Qin X, Selvarangan R, Tang YW, Zheng X, Dien Bard J, Hong T, Prichard M, Brooks E, Dallas S, Duffy L, Mixon E, Fowler KB, Atkinson TP (2019) Macrolide-resistant mycoplasma pneumoniae in the United States as determined from a national surveillance program. J Clin Microbiol 57(11):e00968–19. https://doi.org/10.1128/JCM.00968-19

    Article  PubMed  PubMed Central  Google Scholar 

  • Wan R, Jia M, Dou H, Tu P, Shi D, Yuan Q, Xin D (2022) Mechanism of infantile feire kechuan oral solution against mycoplasma pneumoniae infection of A549 cells. Biomed Pharmacother 145:112366

    Article  CAS  PubMed  Google Scholar 

  • Wang X, Zhong LJ, Chen ZM, Zhou YL, Ye B, Zhang YY (2018) Necrotizing pneumonia caused by refractory mycoplasma pneumonia pneumonia in children. World J Pediatr 14(4):344–349

    Article  PubMed  Google Scholar 

  • Wang, Y., Li, H., Shi, Y., Wang, S., Xu, Y., Li, H. & Liu, D. miR-143–3p impacts on pulmonary inflammatory factors and cell apoptosis in mice with mycoplasmal pneumonia by regulating TLR4/MyD88/NF-kappaB pathway, Biosci Rep 40(7):BSR20193419, https://doi.org/10.1042/BSR20193419 (2020).

  • Wang Z, Wang Q, Xu G, Meng N, Huang X, Jiang Z, Chen C, Zhang Y, Chen J, Li A, Li N, Zou X, Zhou J, Ding Q, Wang S (2020b) The long noncoding RNA CRAL reverses cisplatin resistance via the miR-505/CYLD/AKT axis in human gastric cancer cells. RNA Biol 17(11):1576–1589

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang H, Liu W, Luo B (2021a) The roles of miRNAs and lncRNAs in Epstein-Barr virus associated epithelial cell tumors. Virus Res 291:198217

    Article  CAS  PubMed  Google Scholar 

  • Wang J, Luo X, Cai S, Sun J, Wang S, Wei X (2021b) Blocking HOTAIR protects human chondrocytes against IL-1beta-induced cell apoptosis, ECM degradation, inflammatory response and oxidative stress via regulating miR-222-3p/ADAM10 axis. Int Immunopharmacol 98:107903

    Article  CAS  PubMed  Google Scholar 

  • Wang M, Xie F, Lin J, Zhao Y, Zhang Q, Liao Z, Wei P (2021c) Diagnostic and prognostic value of circulating CircRNAs in cancer. Front Med (lausanne) 8:649383

    Article  PubMed  Google Scholar 

  • Wang P, Zhou Y, Richards AM (2021d) Effective tools for RNA-derived therapeutics: siRNA interference or miRNA mimicry. Theranostics 11(18):8771–8796

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Weivoda MM, Lee SK, Monroe DG (2021) miRNAs in osteoclast biology. Bone 143:115757

    Article  CAS  PubMed  Google Scholar 

  • Winkle M, El-Daly SM, Fabbri M, Calin GA (2021) Noncoding RNA therapeutics - challenges and potential solutions. Nat Rev Drug Discov 20(8):629–651

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wu Z, Wang L, Li J, Wang L, Wu Z, Sun X (2018) Extracellular vesicle-mediated communication within host-parasite interactions. Front Immunol 9:3066

    Article  CAS  PubMed  Google Scholar 

  • Xu, X., Lai, Y. & Hua, ZC. Apoptosis and apoptotic body: disease message and therapeutic target potentials, Biosci Rep 39(1):BSR20180992, https://doi.org/10.1042/BSR20180992 (2019).

  • Xu T, Wu YX, Sun JX, Wang FC, Cui ZQ, Xu XH (2019b) The role of miR-145 in promoting the fibrosis of pulmonary fibroblasts. J Biol Regul Homeost Agents 33(5):1337–1345

    CAS  PubMed  Google Scholar 

  • Xu C, Deng H, Liu F, Zhao D, Tang H, Gu H (2022) Long non-coding RNA PACER regulates mycoplasma pneumoniae-induced inflammatory response through Interaction with NF-kappaB. Ann Clin Lab Sci 52(1):21–26

    CAS  PubMed  Google Scholar 

  • Yang Q, Al-Hendy A (2022) The regulatory functions and the mechanisms of long non-coding RNAs in cervical cancer. Cells 11(7):1149

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yang L, Zhang X, Liu X (2021a) Long non-coding RNA GAS5 protects against Mycoplasma pneumoniae pneumonia by regulating the microRNA-222-3p/TIMP3 axis. Mol Med Rep 23(5):380. https://doi.org/10.3892/mmr.2021.12019

    Article  CAS  PubMed  Google Scholar 

  • Yang Z, Lin SD, Zhan F, Liu Y, Zhan YW (2021b) LncRNA GAS5 alleviates rheumatoid arthritis through regulating miR-222-3p/Sirt1 signalling axis. Autoimmunity 54(1):13–22

    Article  CAS  PubMed  Google Scholar 

  • Yang T, Wang J, Zhao J, Liu Y (2022) Current and prospective applications of exosomal microRNAs in pulmonary fibrosis (Review). Int J Mol Med 49(3):37

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yin L, Ma Y, Wang W, Zhu Y (2021) The critical function of miR-1323/Il6 axis in children with Mycoplasma pneumoniae pneumonia. J Pediatr (rio J) 97(5):552–558

    Article  PubMed  Google Scholar 

  • Yu H, Lin L, Zhang Z, Zhang H, Hu H (2020) Targeting NF-kappaB pathway for the therapy of diseases: mechanism and clinical study. Signal Transduct Target Ther 5(1):209

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yuan Y, Jiaoming L, Xiang W, Yanhui L, Shu J, Maling G, Qing M (2018) Analyzing the interactions of mRNAs, miRNAs, lncRNAs and circRNAs to predict competing endogenous RNA networks in glioblastoma. J Neurooncol 137(3):493–502

    Article  PubMed  Google Scholar 

  • Zang J, Lu D, Xu A (2020) The interaction of circRNAs and RNA binding proteins: an important part of circRNA maintenance and function. J Neurosci Res 98(1):87–97

    Article  CAS  PubMed  Google Scholar 

  • Zhang T, Ma C, Zhang Z, Zhang H, Hu H (2020) NF-kappaB signaling in inflammation and cancer. MedComm 2(4):618–653

    Article  Google Scholar 

  • Zhang H, Li X, Wang J, Cheng Q, Shang Y, Wang G (2021a) Baicalin relieves mycoplasma pneumoniae infectioninduced lung injury through regulating microRNA221 to inhibit the TLR4/NFkappaB signaling pathway. Mol Med Rep 24(2):571. https://doi.org/10.3892/mmr.2021.12210

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhang S, Chen H, Yue D, Blackwell TS, Lv C, Song X (2021b) Long non-coding RNAs: promising new targets in pulmonary fibrosis. J Gene Med 23(3):e3318

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhang F, Zhang J, Liu F, Zhou Y, Guo Y, Duan Q, Zhu Y, Zhao D, Gu H (2021c) Attenuated lncRNA NKILA enhances the secretory function of airway epithelial cells stimulated by mycoplasma pneumoniae via NF-kappaB. Biomed Res Int 2021:6656298

    PubMed  PubMed Central  Google Scholar 

  • Zhang Z, Wan R, Yuan Q, Dou H, Tu P, Shi D, Fu X, Xin D (2022a) Cell damage and neutrophils promote the infection of mycoplasma pneumoniae and inflammatory response. Microb Pathog 169:105647

    Article  CAS  PubMed  Google Scholar 

  • Zhang X, Tang X, Pan L, Li Y, Li J, Li C (2022b) Elevated lncRNA-UCA1 upregulates EZH2 to promote inflammatory response in sepsis-induced pneumonia via inhibiting HOXA1. Carcinogenesis 43(4):371–381

    Article  CAS  PubMed  Google Scholar 

  • Zhao J, Lee EE, Kim J, Yang R, Chamseddin B, Ni C, Gusho E, Xie Y, Chiang CM, Buszczak M, Zhan X, Laimins L, Wang RC (2019) Transforming activity of an oncoprotein-encoding circular RNA from human papillomavirus. Nat Commun 10(1):2300

    Article  PubMed  PubMed Central  Google Scholar 

  • Zhao C, Lv Y, Duan Y, Li G, Zhang Z (2020) Circulating non-coding RNAs and cardiovascular diseases. Adv Exp Med Biol 1229:357–367

    Article  CAS  PubMed  Google Scholar 

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Funding

This work was supported by the Scientific Research Project of Hunan Provincial Health Committee (Grant No. B202311007730 and No. 20201915), and the Clinical Medical Technology Innovation Guidance Project of Hunan Province (Grant No. 2020SK51901).

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Authors and Affiliations

  1. The Affiliated Nanhua Hospital, Department of Clinical Laboratory, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China

    Tian Gan, Jianwei Yu & Jun He

  2. Department of Public Health Laboratory Sciences, School of Public Health, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China

    Jianwei Yu

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  1. Tian Gan
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Contributions

TG prepared and wrote the original draft. JWY handled the design of the figure, and JH was responsible for the supervision. JH provided a critical opinion for this review. All authors contributed to the review and approved the submitted manuscript.

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Communicated by Yusuf Akhter.

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Gan, T., Yu, J. & He, J. miRNA, lncRNA and circRNA: targeted molecules with therapeutic promises in Mycoplasma pneumoniae infection. Arch Microbiol 205, 293 (2023). https://doi.org/10.1007/s00203-023-03636-3

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