Abstract
Endophytes are considered the repository of bioactive compounds as they contain a wide variety of chemically and structurally diverse secondary metabolites. The endophytes associated with Solanum species have been studied for the last few years. Therefore, the present study aimed to discuss the bioactive compounds produced by endophytes associated with Solanum species and their biological activities. Our study reveals that among the Solanum species, only 13 species have been studied in the context of endophytes so far. Overall, a total number of 98 bioactive compounds have been reported from endophytes associated with Solanum species, of which 64 compounds are from fungi and 34 compounds from bacteria. These bioactive compounds belong to different chemical groups such as sterols, flavonoids, volatiles, and many others and exhibited diverse biological activities including antimicrobial, anticancer, antiparasitic, antioxidants, and plant growth-promoting activity. Moreover, the endophytic fungi were reported to produce two compounds that are often present in the host plants. These condensed data may open the door for further research and provide details on potent endophytes associated with Solanum species.
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References
Abayneh L, Ayele A, Lamore T, Sebaro D, Srinivasan V (2022) Enumeration and identification of surface endophytes of Solanum lycopersicum and their seasonal recurrence. Asian J Biol Sci 11(2):525. https://doi.org/10.5530/ajbls.2022.11.71
Abdallah RA, Jabnoun-Khiareddine H, Nefzi A, Mokni-Tlili S, Daami-Remadi M (2016) Biocontrol of Fusarium wilt and growth promotion of tomato plants using endophytic bacteria isolated from Solanum elaeagnifolium stems. J Phytopathol 10(164):811–824. https://doi.org/10.1111/jph.12501
Adedire OM, Aduramigba-Modupe AO, Odeniyi OA (2023) Antifungal potential of endophytic Bacillus species isolated from tomato (Solanum lycopersicum) against Fusarium oxysporum collected from selected farms in Nigeria. J Crop Improv. https://doi.org/10.1080/15427528.2022.2155896
Alam MB, Chowdhury NS, Sohrab MH, Rana MS, Hasan CM, Lee SH (2020) Cerevisterol alleviates inflammation via suppression of MAPK/NF-κB/AP-1 and activation of the Nrf2/HO-1 signaling cascade. Biomolecules 10(2):199. https://doi.org/10.3390/biom10020199
Anwar S, Khan S, Anjum F, Shamsi A, Khan P, Fatima H, Shafie A, Islam A, Hassan MI (2022) Myricetin inhibits breast and lung cancer cell proliferation via inhibiting MARK4. J Cell Biochem 123(2):359–374. https://doi.org/10.1002/jcb.30176
Aydi-Ben-Abdallah R, Jabnoun-Khiareddine H, Daami-Remadi M (2020) Fusarium wilt biocontrol and tomato growth stimulation, using endophytic bacteria naturally associated with Solanum sodomaeum and S. bonariense plants. Egypt J Biol Pest Control 30:1–13. https://doi.org/10.1186/s41938-020-00313-1
Bhuvaneswari S, Madhavan S, Panneerselvam A (2013) Enumertion of endophytic bacteria from Solanum trilobatum L. World J Pharm Res 3:2270–2279
Boguś MI, Wrońska AK, Kaczmarek A, Boguś-Sobocińska M (2021) In-vitro screening of 65 mycotoxins for insecticidal potential. PLoS ONE 16(3):e0248772. https://doi.org/10.1371/journal.pone.0248772
Chen L, Luo S, Xiao X, Guo H, Chen J, Wan Y, Li B, Xu T, Xi Q, Rao C, Liu C (2010) Application of plant growth-promoting endophytes (PGPE) isolated from Solanum nigrum L. for phytoextraction of Cd-polluted soils. Appl Soil Ecol 46(3):383–389. https://doi.org/10.1016/j.apsoil.2010.10.003
Cochard B, Giroud B, Crovadore J, Chablais R, Arminjon L, Lefort F (2022) Endophytic PGPR from tomato roots: isolation, in-vitro characterization and in vivo evaluation of treated tomatoes (Solanum lycopersicum L.). Microorganisms 10(4):765. https://doi.org/10.3390/microorganisms10040765
Devari S, Jaglan S, Kumar M, Deshidi R, Guru S, Bhushan S, Kushwaha M, Gupta AP, Gandhi SG, Sharma JP, Taneja SC (2014) Capsaicin production by Alternaria alternata, an endophytic fungus from Capsicum annum; LC–ESI–MS/MS analysis. Phytochemistry 98:183–189. https://doi.org/10.1016/j.phytochem.2013.12.001
Di Petrillo A, Orrù G, Fais A, Fantini MC (2022) Quercetin and its derivates as antiviral potentials: a comprehensive review. Phytother Res 36(1):266–278. https://doi.org/10.1002/ptr.7309
Effmert U, Kalderas J, Warnke R, Piechulla B (2012) Volatile mediated interactions between bacteria and fungi in the soil. J Chem Ecol 38(6):665–703. https://doi.org/10.1007/s10886-012-0135-5
El-Hawary SS, Mohammed R, AbouZid SF, Bakeer W, Ebel R, Sayed AM, Rateb ME (2016) Solamargine production by a fungal endophyte of Solanum nigrum. J Appl Microbiol 120(4):900–911. https://doi.org/10.1111/jam.13077
El-Hawary SS, Sayed AM, Rateb ME, Bakeer W, AbouZid SF, Mohammed R (2017) Secondary metabolites from fungal endophytes of Solanum nigrum. Nat Prod Res 31(21):2568–2571. https://doi.org/10.1080/14786419.2017.1327859
Goh YX, Jalil J, Lam KW, Husain K, Premakumar CM (2022) Genistein: a review on its anti-inflammatory properties. Front Pharmacol 13:820969. https://doi.org/10.3389/fphar.2022.820969
Ikram M, Ali N, Jan G, Hamayun M, Jan FG, Iqbal A (2019) Novel antimicrobial and antioxidative activity by endophytic Penicillium roqueforti and Trichoderma reesei isolated from Solanum surattense. Acta Physiol Plant 41:1–11. https://doi.org/10.1007/s11738-019-2957-z
Iqbal S, Hameed S, Shahid M, Hussain K, Ahmad N, Niaz M (2018) In-vitro characterization of bacterial endophytes from tomato (Solanum lycopersicum L.) for phytobeneficial traits. Appl Ecol Environ Res 16(2):1037–1051. https://doi.org/10.15666/aeer/1602_10371051
Jan FG, Hamayun M, Hussain A, Iqbal A, Jan G, Khan SA, Khan H, Lee IJ (2019) A promising growth promoting Meyerozyma caribbica from Solanum xanthocarpum alleviated stress in maize plants. Biosci Rep. https://doi.org/10.1042/BSR20190290
Javed Z, Khan K, Herrera-Bravo J, Naeem S, Iqbal MJ, Raza Q, Sadia H, Raza S, Bhinder M, Calina D, Sharifi-Rad J (2022) Myricetin: targeting signaling networks in cancer and its implication in chemotherapy. Cancer Cell Int 22(1):239. https://doi.org/10.1186/s12935-022-02663-2
Kannan KP, Govindasamy R, Rajendran R, Manaogaran S, Dhakshinamoorthy M (2016) Hydrocarbons from curvularia lunata-a novel promising endophytic fungi isolated from Solanum trilobatum linn. Int J Pharm Technol 1:10–17
Kaunda JS, Zhang YJ (2019) The genus Solanum: an ethnopharmacological, phytochemical and biological properties review. Nat Prod Bioprospect 9:77–137. https://doi.org/10.1007/s13659-019-0201-6
Khan AR, Ullah I, Khan AL, Park GS, Waqas M, Hong SJ, Jung BK, Kwak Y, Lee IJ, Shin JH (2015) Improvement in phytoremediation potential of Solanum nigrum under cadmium contamination through endophytic-assisted Serratia sp. RSC-14 inoculation. Environ Sci Pollut Res 22:14032–14042. https://doi.org/10.1007/s11356-015-4647-8
Kouipou Toghueo RM, Boyom FF (2019) Endophytic fungi from Terminalia species: a comprehensive review. J of Fungi 5(2):43. https://doi.org/10.3390/jof5020043
Kuchkarova NN, Toshmatov ZO, Zhou S, Han C, Shao H (2020) Secondary metabolites with plant growth regulator activity produced by an endophytic fungus Purpureocillium sp. from Solanum rostratum. Chem Nat Compd 56:775–776. https://doi.org/10.1007/s10600-020-03147-3
Lemfack MC, Nickel J, Dunkel M, Preissner R, Piechulla B (2014) mVOC: a database of microbial volatiles. Nucleic Acids Res 42(D1):D744–D748. https://doi.org/10.1093/nar/gkt1250
Li H, Zhang M, Wang Y, Gong K, Yan T, Wang D, Meng X, Yang X, Chen Y, Han J, Duan Y (2022) Daidzein alleviates doxorubicin-induced heart failure via the SIRT3/FOXO3a signaling pathway. Food Funct 13(18):9576–9588. https://doi.org/10.1039/D2FO00772J
López SM, Pastorino GN, Balatti PA (2021) Volatile organic compounds profile synthesized and released by endophytes of tomato (Solanum lycopersici L.) and their antagonistic role. Arch Microbiol 203(4):1383–1397. https://doi.org/10.1007/s00203-020-02136-y
Mamaghani NA, Saremi H, Javan-Nikkhah M, De Respinis S, Pianta E, Tonolla M (2022) Endophytic Cephalotrichum spp. from Solanum tuberosum (potato) in Iran–a polyphasic analysis. Sydowia 74:287–301. https://doi.org/10.12905/0380.sydowia74-2022-0287
Manasa AP, Moutusi S, Mendez DC, Kiranmayee P, Prasannakumar MK (2021) Phytochemical distribution, antimicrobial activity, enzyme production of phylogenetically differentiated endophytes from Solanum violaceum Ortega fruits. Curr Res Environ Appl Mycol 11(1):210–229. https://doi.org/10.5943/cream/11/1/16
Man-si YANG, Wen-xiang WANG, Long-gen LI, Hong-lian AI, Hua-chun GUO (2015) Isolation and identification of secondary metabolites of endophytic fungi from Solanum tuberosum. Nat Prod Res Dev 27(10):1728. https://doi.org/10.16333/j.1001-6880.2015.10.008
Meza-Menchaca T, Suárez-Medellín J, Del Ángel-Piña C, Trigos Á (2015) The amoebicidal effect of ergosterol peroxide isolated from Pleurotus ostreatus. Phytother Res 29(12):1982–1986. https://doi.org/10.1002/ptr.5474
Meza-Menchaca T, Poblete-Naredo I, Albores-Medina A, Pedraza-Chaverri J, Quiroz-Figueroa FR, Cruz-Gregorio A, Zepeda RC, Melgar-Lalanne G, Lagunes I, Trigos Á (2020) Ergosterol peroxide isolated from oyster medicinal mushroom, Pleurotus ostreatus (Agaricomycetes), potentially induces radiosensitivity in cervical cancer. Int J Med Mushrooms 22(11):1109–1119. https://doi.org/10.1615/IntJMedMushrooms.2020036673
Mili C, Roy S, Tayung K (2021) Endophytic fungi of wild and domesticated crop plants and their prospect for applications in sustainable agriculture. In: Patil RH, Maheshwari VL (eds) Endophytes. Springer, Singapore. https://doi.org/10.1007/978-981-15-9371-0_2
Misra D, Ghosh NN, Mandal M et al (2022) Anti-enteric efficacy and mode of action of tridecanoic acid methyl ester isolated from Monochoria hastata (L.) Solms leaf. Braz J Microbiol 53:715–726. https://doi.org/10.1007/s42770-022-00696-3
Mohammad Golam Dastogeer K, Oshita Y, Yasuda M, Kanasugi M, Matsuura E, Xu Q, Okazaki S (2020) Host specificity of endophytic fungi from stem tissue of nature farming tomato (Solanum lycopersicum Mill.) in Japan. Agronomy 10(7):1019. https://doi.org/10.3390/agronomy10071019
Nchabeleng EK (2017) Determination of biological activity of Celtis africana extracts and its endophytic microflora and mycoflora. Masters Thesis, Department of Biotechnology and Food Technology, University of Johannesburg, Johannesburg, South Africa. Available from: https://www.proquest.com/openview/9b17e0c8c4303b3ba148b6c72ab0f5d9/1?pq-origsite=gscholar&cbl=2026366&diss=y (Accessed: 02 February 2023)
Nguyen TLA, Bhattacharya D (2022) Antimicrobial activity of quercetin: an approach to its mechanistic principle. Molecules 27(8):2494. https://doi.org/10.3390/molecules27082494
Norhayati I, Nurhayati ZA, Getha K, Muhd Haffiz J, Adiratna MR (2022) Evaluation of antitrypanosomal properties and apoptotic effects of ochrolifuanine from Dyera costulata (Miq.) Hook f against Trypanosoma brucei brucei. Trop Biomed 39(3):321–327. https://doi.org/10.47665/tb.39.3.003
Padilla-Gálvez N, Luengo-Uribe P, Mancilla S, Maurin A, Torres C, Ruiz P et al (2021) Antagonistic activity of endophytic actinobacteria from native potatoes (Solanum tuberosum subsp. tuberosum L.) against Pectobacterium carotovorum subsp. carotovorum and Pectobacterium atrosepticum. BMC Microbial. 21(1):1–17. https://doi.org/10.1186/s12866-021-02393-x
Pandi M, Kumaran RS, Choi YK, Kim HJ, Muthumary J (2011) Isolation and detection of taxol, an anticancer drug produced from Lasiodiplodia theobromae, an endophytic fungus of the medicinal plant Morinda citrifolia. Afr J Biotechnol 10(8):1428–1435. https://doi.org/10.5897/AJB10.950
Parthasarathy R, Sathiyabama M (2015) Lovastatin-producing endophytic fungus isolated from a medicinal plant Solanum xanthocarpum. Nat Prod Res 29(24):2282–2286. https://doi.org/10.1080/14786419.2015.1016938
Passari AK, Chandra P, Mishra VK, Leo VV, Gupta VK, Kumar B, Singh BP (2016) Detection of biosynthetic gene and phytohormone production by endophytic actinobacteria associated with Solanum lycopersicum and their plant-growth-promoting effect. Res Microbiol 167(8):692–705. https://doi.org/10.1016/j.resmic.2016.07.001
Pelo SP, Adebo OA, Green E (2021) Chemotaxonomic profiling of fungal endophytes of Solanum mauritianum (alien weed) using gas chromatography high resolution time-of-flight mass spectrometry (GC-HRTOF-MS). Metabolomics 17:1–13. https://doi.org/10.1007/s11306-021-01790-7
Pelo SP (2020) Isolation, identification and characterization of fungal endophytes from Solanum mauritianum and their activity against pathogenic microorganisms. University of Johannesburg (South Africa). Available from: https://www.proquest.com/openview/e3529690a07765fde643cfc46c5d382e/1?pq-origsite=gscholar&cbl=2026366&diss=y (Accessed: 02 February 2023)
Ramesh R, Joshi AA, Ghanekar MP (2009) Pseudomonads: major ant agonistic endophytic bacteria to suppress bacterial wilt pathogen, Ralstonia solanacearum in the eggplant (Solanum melongena L.). World J Microbiol Biotechnol 25:47–55. https://doi.org/10.1007/s11274-008-9859-3
Ríos-Moreno A, Garrido-Jurado I, Resquín-Romero G, Arroyo-Manzanares N, Arce L, Quesada-Moraga E (2016) Destruxin A production by Metarhizium brunneum strains during transient endophytic colonisation of Solanum tuberosum. Biocontrol Sci Technol 26(11):1574–1585. https://doi.org/10.1080/09583157.2016.1223274
Romero FM, Marina M, Pieckenstain FL (2014) The communities of tomato (Solanum lycopersicum L.) leaf endophytic bacteria, analyzed by 16S-ribosomal RNA gene pyrosequencing. FEMS Microbiol Lett 351(2):187–194. https://doi.org/10.1111/1574-6968.12377
Sachin N, Manjunatha BL, Kumara PM, Ravikanth G, Shweta S, Suryanarayanan TS, Ganeshaiah KN, Shaanker RU (2013) Do endophytic fungi possess pathway genes for plant secondary metabolites? Curr Sci 104:178–182
Sadrati N, Daoud H, Zerroug A, Dahamna S, Bouharati S (2013) Screening of antimicrobial and antioxidant secondary metabolites from endophytic fungi isolated from wheat (Triticum durum). J Plant Prot Res 53:128–136
Singh M, Kumar A, Pandey KD (2019) Biochemical and molecular identification of Solanum lycopersicum L. temperature tolerant bacterial endophytes. Biocatal Agric Biotechnol 22:101409. https://doi.org/10.1016/j.bcab.2019.101409
Tyc O, Song C, Dickschat JS, Vos M, Garbeva P (2017) The ecological role of volatile and soluble secondary metabolites produced by soil bacteria. Trends Microbiol 25(4):280–292. https://doi.org/10.1016/j.tim.2016.12.002
Uche-Okereafor N, Sebola T, Tapfuma K, Mekuto L, Green E, Mavumengwana V (2019) Antibacterial activities of crude secondary metabolite extracts from Pantoea species obtained from the stem of Solanum mauritianum and their effects on two cancer cell lines. Int J Environ Res Public Health 16(4):602. https://doi.org/10.3390/ijerph16040602
Ullah I, Al-Johny BO, Al-Ghamdi KM, Al-Zahrani HA, Anwar Y, Firoz A et al (2019) Endophytic bacteria isolated from Solanum nigrum L., alleviate cadmium (Cd) stress response by their antioxidant potentials, including SOD synthesis by sodA gene. Ecotoxicol Environ Saf 174:197–207. https://doi.org/10.1016/j.ecoenv.2019.02.074
Vieira ML, Hughes AF, Gil VB, Vaz AB, Alves TM, Zani CL et al (2012) Diversity and antimicrobial activities of the fungal endophyte community associated with the traditional Brazilian medicinal plant Solanum cernuum Vell. (Solanaceae). Can J Microbiol 58(1):54–66. https://doi.org/10.1139/w11-105
Wang J, Berestetskiy A, Hu Q (2021) Destruxin a interacts with aminoacyl trna synthases in bombyx mori. J Fungi 7(8):593. https://doi.org/10.3390/jof7080593
Yasser MM, Mousa ASM, Marzouk Marym A, Tagyan AI (2019) Molecular identification, extracellular enzyme production and antimicrobial activity of endophytic fungi isolated from Solanum tuberosum L. Biosci Biotechnol Res Asia 16(1):135–142. https://doi.org/10.13005/bbra/2731
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Mili, C. Bioprospecting of endophytes associated with Solanum species: a mini review. Arch Microbiol 205, 254 (2023). https://doi.org/10.1007/s00203-023-03596-8
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DOI: https://doi.org/10.1007/s00203-023-03596-8