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The prevalence of osteoporosis and the rate of bone loss in Korean adults: the Chungju metabolic disease cohort (CMC) study

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Abstract

Summary

Because the rate of bone loss is an important risk factor for fracture, we studied longitudinal changes in bone mineral density (BMD). Although the BMD of the hip decreased over time, spine BMD remained largely stable or increased. Therefore, spine BMD may not be appropriate for assessing BMD change.

Introduction

The rate of age-dependent bone loss has been shown to be an important risk factor for fracture. However, longitudinal rates of BMD loss in Korea have not yet been reported. The objective of this study was to evaluate longitudinal changes in BMD in Korea.

Methods

This cohort study was performed in a population of individuals 40 years of age or older living in the rural area of Chungju City, Korea. A second BMD examination was conducted approximately 4 years after a baseline examination. A total of 3755 of the 6007 subjects completed the follow-up visit, corresponding to a follow-up rate of 62.51%.

Results

The age-standardized osteoporosis prevalence was 12.81% in males and 44.35% in females. In males, the average annual BMD loss at the total hip increased from −0.25% per year in their 40s to −1.12% per year in their 80s. In females, the average annual BMD loss at the total hip increased from −0.69% per year in their 40s to −1.51% per year in their 80s. However, the average annual percentage change in spine BMD in females increased from −0.91% per year in their 40s to +1.39% per year in their 80s.

Conclusions

A substantial number of subjects had osteoporosis, even though we standardized the prevalence of osteoporosis. In total hip, the mean BMD was decreased during the follow-up period; in addition, the annual percentage loss increased with age. However, spine BMD remained approximately stable or increased over time and therefore may not be appropriate for assessing BMD change.

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Acknowledgments

This work was supported by a research grant from the Investigator-Initiated Studies Program of Merck & Co., Korea. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The statistical consultation was supported by a grant from The Korean Health Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (grant number: HI14C1062). We thank Hyunyong Lee for his assistance with the statistical analysis.

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Authors and Affiliations

  1. Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, 222 Banpo-daero Seocho-gu, Seoul, 137-701, South Korea

    Y. Lim, K. Jo, K.-H. Yoon, H.-Y. Son, K. H. Baek & M.-I. Kang

  2. Department of Preventive Medicine, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 137-701, South Korea

    H.-S. Ha, H.-W. Yim & W.-C. Lee

  3. Clinical Research Coordinating Center, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 137-701, South Korea

    H.-W. Yim

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  1. Y. Lim
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  2. K. Jo
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Correspondence to K. H. Baek or M.-I. Kang.

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Lim, Y., Jo, K., Ha, HS. et al. The prevalence of osteoporosis and the rate of bone loss in Korean adults: the Chungju metabolic disease cohort (CMC) study. Osteoporos Int 28, 1453–1459 (2017). https://doi.org/10.1007/s00198-016-3893-z

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  • DOI: https://doi.org/10.1007/s00198-016-3893-z

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