Abstract
Periostin is a matricellular glutamate-containing protein expressed during ontogenesis and in adult connective tissues submitted to mechanical strains including bone and, more specifically, the periosteum, periodontal ligaments, tendons, heart valves, or skin. It is also expressed in neoplastic tissues, cardiovascular and fibrotic diseases, and during wound repair. Its biological functions are extensively investigated in fields such as cardiovascular physiology or oncology. Despite its initial identification in bone, investigations of periostin functions in bone-related physiopathology are less abundant. Recently, several studies have analyzed the potential role of periostin in bone biology and suggest that periostin may be an important regulator of bone formation. The aim of this article is to provide an extensive review on the implications of periostin in bone biology and its potential use in benign and metabolic bone diseases.
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Abbreviations
- βig-H3 protein:
-
transforming growth factor-β-inducible protein
- BMP:
-
bone morphogenetic protein
- CRS:
-
carboxylase recognition sites
- dpc:
-
days postconception
- DPD:
-
deoxypyridinoline
- DHLNL:
-
dihydroxylysinonorleucine
- ECM:
-
extracellular matrix
- FAK:
-
focal adhesion kinase
- FGF:
-
basic fibroblast growth factors
- Gla:
-
γ-carboxyglutamate
- Glu:
-
glutamate
- HLNL:
-
hydroxylysinonorleucine
- LOX:
-
lysyl oxidase
- PDL:
-
periodontal ligament
- PDGF:
-
platelet-derived growth factor
- PHPT:
-
primary hyperparathyroidism
- PLF:
-
periostin-like factor
- PTH:
-
parathyroid hormone
- PTHrP:
-
parathyroid hormone-related peptide
- PYD:
-
pyridinoline
- TNFα:
-
tumor necrosis factor α
- TRAP5b:
-
tartrate resistant acid phosphatase
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The authors would like to thank Dr. Sylvain Contie for helpful discussion on this manuscript.
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Merle, B., Garnero, P. The multiple facets of periostin in bone metabolism. Osteoporos Int 23, 1199–1212 (2012). https://doi.org/10.1007/s00198-011-1892-7
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DOI: https://doi.org/10.1007/s00198-011-1892-7