Skip to main content

Periostin in Bone Biology

  • Chapter
  • First Online:
Periostin

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1132))

Abstract

Periostin is specifically expressed in periosteum that functions in bone modeling and remodeling and bone repair, and is sensitive to mechanical stress. Thus periostin has been expected for controlling these crucial systems in bone. The results from periostin deficient mice demonstrate that periostin acts on bone remodeling though detailed mechanisms are unknown. Recent findings have revealed that periostin is essential for bone repair. In this chapter, I introduce expression and function of periostin in bone.

Material in this chapter has been adapted from Kudo [19] with permission.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Allen MR, Hock JM, Burr DB (2004) Periosteum: biology, regulation, and response to osteoporosis therapies. Bone 35:1003–1012

    Article  CAS  Google Scholar 

  2. Bonnet N, Standley KN, Bianchi EN, Stadelmann V, Foti M, Conway SJ, Ferrari SL (2009) The matricellular protein periostin is required for sost inhibition and the anabolic response to mechanical loading and physical activity. J Biol Chem 284:35939–35950

    Article  CAS  Google Scholar 

  3. Bonnet N, Gineyts E, Ammann P, Conway SJ, Garnero P, Ferrari S (2013) Periostin deficiency increases bone damage and impairs injury response to fatigue loading in adult mice. PLoS One 8:e78347

    Article  CAS  Google Scholar 

  4. Bonnet N, Brun J, Rousseau J-C, Duong LT, Ferrari SL (2017) Cathepsin K controls cortical bone formation by degrading periostin. J Bone Miner Res 32(7):1432–1441

    Article  CAS  Google Scholar 

  5. Brown JM, Mantoku A, Sabokbar A, Oppermann U, Hassan AB, Kudo A, Athanasou N (2018) Periostin expression in neoplastic and non-neoplastic diseases of bone and joint. Clin Sarcoma Res 8:18

    Article  Google Scholar 

  6. Canty EG, Kadler KE (2005) Procollagen trafficking, processing and fibrillogenesis. J Cell Sci 118:1341–1353

    Article  CAS  Google Scholar 

  7. Chijimatsu R, Kunugiza Y, Taniyama Y, Nakamura N, Tomita T, Yoshikawa H (2015) Expression and pathological effects of periostin in human osteoarthritis cartilage. BMC Musculoskelet Disord 16:215

    Article  Google Scholar 

  8. Chiquet M, Gelman L, Lutz R, Maier S (2009) From mechanotransduction to extracellular matrix gene expression in fibroblasts. Biochem Biophys Acta 1793:911–920

    Article  CAS  Google Scholar 

  9. de Lageneste PD, Julien A, Abou-Khalil R, Frangi G, Carvalho C, Cagnard N, Cordier C, Conway SJ, Colnot C (2018) Periostium contains skeletal stem cells with high bone regenerative potential controlled by periostin. Nat Commun 9:773

    Article  Google Scholar 

  10. Dwek JR (2010) The periosteum: what is it, where is it, and what mimics it in its absence? Skelet Radiol 39:319–323

    Article  Google Scholar 

  11. Erez N (2015) Opening LOX to metastasis. Nature 522:41–42

    Article  CAS  Google Scholar 

  12. Gartland A, Erler JT, Cox TR (2016) The role of lysyl oxidase, the extracellular matrix and pre-metastatic niche in bone metastasis. J Bone Oncol 5:100–103

    Article  Google Scholar 

  13. Hirose Y, Suzuki H, Amizuka N, Shimomura J, Kawano Y, Nozawa-Inoue K, Kudo A, Maeda T (2003) Immunohistochemical localization of periostin in developing long bones of mice. Biomed Res 24:31–37

    Article  CAS  Google Scholar 

  14. Horiuchi K, Amizuka N, Takeshita S, Takamatsu H, Katsuura M, Ozawa H, Toyama Y, Bonewald LF, Kudo A (1999) Identification and characterization of a novel protein, periostin with restricted expression to periosteum and periodontal ligament and increased expression by transforming growth factor β. J Bone Miner Res 14:1239–1249

    Article  CAS  Google Scholar 

  15. Inaki R, Fujihara Y, Kudo A, Misawa M, Hikita A, Takato T, Hoshi K (2018) Periostin contributes to the maturation and shape retention of tissue-engineered cartilage. Sci Rep 8:11210

    Article  Google Scholar 

  16. Kashima TG, Nishiyama T, Shimazu K, Shimazaki M, Kii I, Grigoriadis AE, Fukayama M, Kudo A (2009) Periostin, a novel marker of intramembranous ossification, is expressed in fbrous dysplasia and in c-Fos-overexpressing bone lesions. Hum Pathol 40:226–237

    Article  CAS  Google Scholar 

  17. Kii I, Nishiyama T, Li M, Matsumoto K, Saito M, Amizuka N, Kudo A (2010) Incorporation of tenascin-C into the extracellular matrix by periostin underlies an extracellular meshwork architecture. J Biol Chem 285:2028–2039

    Article  CAS  Google Scholar 

  18. Kii I, Nishiyama T, Kudo A (2016) Periostin promotes secretion of fibronectin from the endoplastic reticulum. Biochem Biophys Res Commun 470:888–893

    Article  CAS  Google Scholar 

  19. Kudo A (2011) Periostin in fibrillogenesis for tissue regeneration: periostin actions inside and outside the cell. Cell Mol Life Sci 68:3201–3207

    Article  CAS  Google Scholar 

  20. Maruhashi T, Kii I, Saito M, Kudo A (2010) Interaction between periostin and BMP-1 promotes proteolytic activation of lysyl oxidase. J Biol Chem 285:13294–13303

    Article  CAS  Google Scholar 

  21. Merle B, Garnero P (2012) The multiple facets of periostin in bone metabolism. Osteoporos Int 23:1199–1212

    Article  CAS  Google Scholar 

  22. Norris RA, Damon B, Mironov V, Kasyanov V, Ramamurthi A, Moreno-Rodriguez R, Trusk T, Potts JD, Goodwin RL, Davis J, Hoffman S, Wen X, Sugi Y, Kern CB, Mjaatvedt CH, Turner DK, Oka T, Conway SJ, Molkentin JD, Forgacs G, Markwald RR (2007) Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues. J Cell Biochem 101:695–711

    Article  CAS  Google Scholar 

  23. Oshima A, Tanabe H, Yan T, Lowe GN, Glackin CA, Kudo A (2002) A novel mechanism for the regulation of osteoblast differentiation: transcription of periostin, a member of the fasciclin family, is regulated by the bHLH transcription factor, twist. J Cell Biochem 86:792–804

    Article  CAS  Google Scholar 

  24. Shimazaki M, Nakamura K, Kii I, Kashima T, Amizuka N, Li M, Saito M, Fukuda K, Nishiyama T, Kitajima S, Saga Y, Fukayama M, Sata M, Kudo A (2008) Periostin is essential for cardiac healing after acute myocardial infarction. J Exp Med 205:295–303

    Article  CAS  Google Scholar 

  25. Tang Y, Liu L, Wang P, Chen D, Wu Z, Tang C (2017) Periostin promotes migration and osteogenic differentiation of human periodontal ligament mesenchymal stem cells via the Jun amino-terminal kinases (JNK) pathway under inflammatory conditions. Cell Prolif 2017:e12369

    Article  Google Scholar 

  26. Walsh JS, Gossiel F, Scott JR, Paggiosi MA, Eastell R (2017) Effect of age and gender on serum periostin: relationship to cortical measures, bone turnover and hormones. Bone 99:8–13

    Article  CAS  Google Scholar 

Download references

Acknowledgment

I thank Dr. Kii in Riken for providing the figure.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Akira Kudo .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Kudo, A. (2019). Periostin in Bone Biology. In: Kudo, A. (eds) Periostin. Advances in Experimental Medicine and Biology, vol 1132. Springer, Singapore. https://doi.org/10.1007/978-981-13-6657-4_5

Download citation

Publish with us

Policies and ethics