The Annals of Regional Science

, Volume 51, Issue 1, pp 213–244 | Cite as

Agglomeration economies, inventors and entrepreneurs as engines of European regional economic development

  • Frank G. van OortEmail author
  • Niels S. Bosma
Special Issue Paper


In economic agglomeration studies, the distinction of various externalities circumstances related to knowledge spillovers remains largely unclear. This paper introduces human capital, innovation and several types of entrepreneurship as potential drivers of regional economic performance with an impact of agglomeration economies. We use measures of specific types of entrepreneurship, discerned at the individual level, as well as human capital and invention through patenting activity for the period 2001–2006. The empirical application on 111 regions across 14 European countries investigates their relation with observed regional productivity rates in 2006. Our main findings indicate that (i) human capital, patenting activity and entrepreneurship are all linked to regional performance, more so in regions containing large as well as medium-sized cities; (ii) they act as complements rather than substitutes, facilitating productivity differently; and (iii) accounting for patenting activity and entrepreneurship captures agglomeration externalities effects previously subscribed only to the density of resources of regional performance. The particular role of regions with medium-sized cities next to regions with large cities complies with observed growth trends as well as recently proposed place-based development approaches that assume that interactions between institutions and geography are critical for regional economic performance.

JEL Classification

R12 L26 O30 


  1. Acs ZJ (2002) Innovation and the growth of cities. Edward Elgar, CheltenhamGoogle Scholar
  2. Acs ZJ (2008) Foundations of high impact entrepreneurship. Jena economic research papers. \(\#\), 2008–060. Max Planck Institute of Economics, JenaGoogle Scholar
  3. Acs ZJ, Armington C (2004) Employment growth and entrepreneurial activity in cities. Reg Stud 38:911–927Google Scholar
  4. Acs ZJ, Varga A (2005) Entrepreneurship, agglomeration and technological change. Small Bus Econ 24(3):323–334CrossRefGoogle Scholar
  5. Acs ZJ, Storey DJ (2004) Introduction: entrepreneurship and economic development. Reg Stud 38(8):871–877Google Scholar
  6. Acs ZJ, Plummer LA (2005) Penetrating the “knowledge filter” in regional economies. Ann Reg Sci 39(3):439–456CrossRefGoogle Scholar
  7. Acs ZJ, Audretsch DB, Braunerhjelm P, Carlsson B (2010) The missing link: knowledge diffusion and entrepreneurship in endogenous growth. Small Bus Econ 34(2):105–125CrossRefGoogle Scholar
  8. Acs ZJ, Bosma NS, Sternberg R (2011) Entrepreneurship in world cities. In: Minniti M (ed) The dynamics of entrepreneurial activity. Oxford University Press, Oxford, pp 125–151CrossRefGoogle Scholar
  9. Aghion P, Blundell R, Grifith R, Howitt P, Prantl S (2009) The effects of entry on incumbent innovation and productivity. Rev Econ Stat 91(9):20–32CrossRefGoogle Scholar
  10. Andersson M, Koster S (2011) Sources of persistence in regional start-up rates-evidence from Sweden. J Econ Geogr 11(1):179–201Google Scholar
  11. Artis MJ, Miguelez E, Moreno R (2012) Agglomeration economies and regional intangible assets: an empirical investigation. J Econ Geogr, first published, online 4 Nov 2011. doi: 10.1093/jeg/lbr031
  12. Asheim BT (1996) Industrial districts as ‘learning regions’: a condition for prosperity. Eur Plan Stud 4(4):379–400CrossRefGoogle Scholar
  13. Audretsch DB, Feldman MP (1996) R &D spillovers and the geography of innovation and production. Am Econ Rev 86(3):630–640Google Scholar
  14. Audretsch DB, Keilbach MP (2005) Entrepreneurship capital and regional growth. Ann Reg Sci 39:457–469CrossRefGoogle Scholar
  15. Barca F (2009) An agenda for a reformed cohesion policy: a place-based approach to meeting European Union challenges and expectations. Report for the European Commission, BrusselsGoogle Scholar
  16. Barca F, McCann P, Rodriguez-Pose A (2012) The case for regional development intervention: place-based versus place-neutral approaches. J Reg Sci 52:134–152CrossRefGoogle Scholar
  17. Baumol WJ (1990) Entrepreneurship: productive, unproductive, and destructive. J Polit Econ 98(5):893–921CrossRefGoogle Scholar
  18. Beaudry C, Schiffauerova A (2009) Who’s right, Marshall or Jacobs? The localization versus urbanization debate. Res Policy 38:318–337CrossRefGoogle Scholar
  19. Becker R, Henderson JV (2000) Intraindustry specialization and urban development. In: Huriot JM, Thisse JF (eds) Economics of cities: theoretical perspectives. Cambridge University Press, Cambridge, pp 138–166Google Scholar
  20. Bosker M (2007) Growth, agglomeration and convergence: a space-time analysis for European regions. Spatial Econ Anal 2:91–108CrossRefGoogle Scholar
  21. Bosma NS, Van Praag M, Thurik R, De Wit G (2004) The value of human and social capital investments for the business performance of startups. Small Bus Econ 23(3):227–236CrossRefGoogle Scholar
  22. Bosma N, Schutjens V, Stam E (2009) Entrepreneurship in European regions: implications for public policy. In: Leitao J, Baptista R (eds) Public policies for fostering entrepreneurship. Springer, New York, pp 59–89CrossRefGoogle Scholar
  23. Bosma NS (2011) Entrepreneurship, urbanisation economies and productivity of European regions. In: Fritsch MF (ed) Handbook of research on entrepreneurship and regional development, Cheltenham (UK). Edward Elgar, Northampton, pp 107–132Google Scholar
  24. Bosma NS, Wennekers S, Amorós JE (2012) Global entrepreneurship monitor 2011 extended global report: entrepreneurs and entrepreneurial employees across the globe, Babson Park, MA, US: Babson College, Santiago, Chile: Universidad del Desarollo, Kuala Lumpur, Malaysia: Universiti Tun Abdul Razak and London, UK: Global Entrepreneurship Research AssociationGoogle Scholar
  25. Bosma NS, Stam E, Schutjens VAJM (2011) Creative destruction and regional productivity growth: evidence from Dutch manufacturing and services. Small Bus Econ 36(4):401–418CrossRefGoogle Scholar
  26. Brenner T, Fornahl D (2008) Regional path-dependence in start-up activity. Papers in evolutionary economic geography nr. 08.12. Utrecht University, UtrechtGoogle Scholar
  27. Breschi S, Lissoni F (2009) Mobility of skilled workers and co-invention networks: an anatomy of localized knowledge flows. J Econ Geogr 9:439–468CrossRefGoogle Scholar
  28. Breschi S, Malerba F, Orsenigo L (2000) Technologicl regimes and Schumpetarian patterns of innovation. Econ J 110(463):388–410CrossRefGoogle Scholar
  29. Camagni R (ed) (1991) Innovation networks. Spatial perspectives. Bellhaven Press, LondonGoogle Scholar
  30. Ciccone A (2002) Agglomeration effects in Europe. Eur Econ Rev 46(2):213–227CrossRefGoogle Scholar
  31. Ciccone A, Hall RE (1996) Productivity and the density of economic activity. Am Econ Rev 86(1):54–70Google Scholar
  32. Combes PP, Overman H (2004) The spatial distribution of economic activities in the European Union. In: Henderson JV, Thisse J (eds) Handbook of regional and urban economics. Elsevier, Amsterdam, pp 2120–2167Google Scholar
  33. Cooke P (2001) Regional innovation systems, clusters, and the knowledge economy. Ind Corp Change 10(4):945–974CrossRefGoogle Scholar
  34. Coyne CJ, Sobel RS, Dove JA (2010) The non-productive entrepreneurial process. Rev Austrian Econ. doi: 10.1007/s11138-010-0124-2
  35. De Groot HLF, Poot J, Smit MJ (2009) Agglomeration externalities, innovation and regional growth: theoretical perspectives and meta-analysis. In: Nijkamp P, Capello R (eds) Handbook of regional growth and development theories. Edward Elgar, pp 256–281Google Scholar
  36. Dogaru T, van Oort F, Thissen M (2011) Agglomeration economies in European regions: perspectives for objective-1 regions. Tijdschrift voor Econ Soc Geogr 102:486–494CrossRefGoogle Scholar
  37. Dühr S, Colomb C, Nadin V (2010) European spatial panning and territorial cooperation. Routledge, LondonGoogle Scholar
  38. Duranton G, Puga D (2001) Nursery cities: urban diversity, process innovation, and the life cycle of products. Am Econ Rev 91:1454–1477CrossRefGoogle Scholar
  39. Duranton G, Puga D (2004) Micro-foundations of urban agglomeration economies. In: Henderson JV, Thisse J-F (eds) Handbook of urban and regional economics, vol. 4. North Holland, New York, pp 2063–2118Google Scholar
  40. Feser EJ (2002) Tracing the sources of local external economies. Urban Stud 39:2485–2506CrossRefGoogle Scholar
  41. Frenken K, van Oort FG, Verburg T (2007) Related variety, unrelated variety and regional economic growth. Reg Stud 41:685–697CrossRefGoogle Scholar
  42. Fritsch M, Mueller P (2007) The persistence of regional new business formation-activity over time—assessing the potential of policy promotion programs. J Evol Econ 17:299–315CrossRefGoogle Scholar
  43. Fritsch M, Mueller P (2008) The effect of new business formation on regional development over time: the case of Germany. Small Bus Econ 30(1):15–29CrossRefGoogle Scholar
  44. Fritsch M, Schroeter A (2011) Why does the effect of new business formation differ across regions? Small Bus Econ 36(4):383–400CrossRefGoogle Scholar
  45. Getis A, Ord JK (1992) The analysis of spatial association by use of distance statistics. Geogr Anal 24(3):189–206CrossRefGoogle Scholar
  46. Glaeser EL, Kallal HD, Scheinkman JA, Schleifer A (1992) Growth in cities. J Polit Econ 100:1126–1152CrossRefGoogle Scholar
  47. Glaeser EL, Maré DC (2001) Cities and Skills. J Labor Econ 19(2):316–342Google Scholar
  48. Henderson JV (2003) Marshall’s scale economies. J Urban Econ 53:1–28CrossRefGoogle Scholar
  49. Holcombe RG (1998) Entrepreneurship and economic growth. Q J Austrian Econ 1(2):45–62CrossRefGoogle Scholar
  50. Jaffe AB, Trajtenberg M, Henderson R (1993) Geographic localization and knowledge spillovers as evidenced by patent citations. Q J Econ 108:577–598CrossRefGoogle Scholar
  51. Keeble D, Wever E (1986) New firms and regional development in Europe. Croom Helm, LondonGoogle Scholar
  52. Koster S (2007) The entrepreneurial and replication function of new firm formation. Tijdschr Econ Soc Geogr 98(5):667–674CrossRefGoogle Scholar
  53. Krugman P (2009) The increasing returns revolution in trade and geography. Am Econ Rev 99:561–571CrossRefGoogle Scholar
  54. Lopez-Rodriguez J, Faiña A (2006) Objective 1 regions versus non-Objective 1 regions: what does the Theil Index tell us? Appl Econ Lett 13:815–820Google Scholar
  55. Marrocu E, Paci R, Usai S (2012) Productivity growth in the old and new Europe: the role of agglomeration externalities. J Reg Sci. doi: 10.111/jors.12000
  56. Martin R, Sunley P (2006) Path dependence and regional economic evolution. J Econ Geogr 6:395–437CrossRefGoogle Scholar
  57. McCann P, van Oort FG (2009) Theories of agglomeration and regional economic growth: a historical review. In: Capello R, Nijkamp P (eds) Handbook of regional growth and development theories. Edward Elgar, Cheltenham, pp 19–32Google Scholar
  58. Melo PC, Graham DJ, Noland RB (2009) A meta-analysis of estimates of urban agglomeration economies. Reg Sci Urban Econ 39:332–342. doi: 10.1016/j.regsci.urbeco.2008-12.002 Google Scholar
  59. Montfort P (2009) Regional convergence, growth and interpersonal inequalities across the EU. DG Regional Policy, European CommissionGoogle Scholar
  60. OECD (2009) Regions matter: economic recovery, innovation and sustainable growth. OECD, ParisGoogle Scholar
  61. OECD (2011) Regions at a glance 2011. OECD, ParisGoogle Scholar
  62. OECD (2012) Redefining “urban”. A new way to measure metropolitan areas, OECD, ParisGoogle Scholar
  63. Olson M (1982) The rise and decline of nations: economic growth, stagflation, and social rigidities. Yale University Press, ConnecticutGoogle Scholar
  64. Ottaviano GP (2011) ‘New’ new economic geography: firm heterogeneity and agglomeration economies. J Econ Geogr 11:231–240CrossRefGoogle Scholar
  65. Parker SC (2005) Explaining regional variations in entrepreneurship as multiple equilibria. J Reg Sci 45:829–850CrossRefGoogle Scholar
  66. Reynolds P, Storey DJ, Westhead P (1994) Crossnational comparisons of the variation in new firm formation rates: an editorial overview. Reg Stud 28(4):343–346CrossRefGoogle Scholar
  67. Reynolds PD, Bosma NS, Autio E, Hunt S, De Bono N, Servais I, Lopez-Garcia P, Chin N (2005) Global entrepreneurship monitor: data collection design and implementation 1998–2003. Small Bus Econ 24(3):205–231CrossRefGoogle Scholar
  68. Rosenthal SS, Strange WC (2004) Evidence on the nature and sources of agglomeration economies. In: Henderson JV, Thisse J-F (eds) Handbook of urban and regional economics, vol 4. Elsevier, Amsterdam, pp 2119–2172Google Scholar
  69. Rosenthal SS, Strange WC (2001) The determinants of agglomeration. J Urban Econ 59:191–229CrossRefGoogle Scholar
  70. Santarelli E, Vivarelli M (2007) Entrepreneurship and the process of firms’ entry, survival and growth. Ind Corp Change 16(3):455–488CrossRefGoogle Scholar
  71. Schumpeter JA (1947) The creative responses in economic history. J Econ Hist 7(2):149–159Google Scholar
  72. Schumpeter JA (1934) The theory of economic development. Harvard University Press, CambridgeGoogle Scholar
  73. Schumpeter JA (1942) Capitalism, socialism and democracy. Harper and Row, New YorkGoogle Scholar
  74. Stam E (2008) Entrepreneurship and innovation policy. In: Nooteboom B, Stam E (eds) Micro-foundations for innovation policy. Amsterdam University Press, AmsterdamGoogle Scholar
  75. Storper M (1992) The limits to globalization. Technology districts and international trade. economic Geogr 68(1):60–93CrossRefGoogle Scholar
  76. Tamásy C (2006) Determinants of regional entrepreneurship dynamics in contemporary Germany: A Conceptual and Empirical Analysis. Reg Stud 40(4):365–384Google Scholar
  77. Thissen MJPM, Ruijs A, van Oort F, Diodato D (2011) De concurrentiepositie van Nederlandse regio’s. Regionaal-economicsche samenhang in Europa, Netherlands Environmental Assessment Agency (PBL), The HagueGoogle Scholar
  78. Thoma G, Torrisi S, Gambardella A, Guellec D, Hall BH, Harhoff D (2010) Harmonizing and combining large datasets—an application to firm-level patent and accounting data. NBER working paper 15851, National Bureau of Economic Research, CambridgeGoogle Scholar
  79. United Nations (2007) World population prospects: the 2006 revision and world urbanization prospects: the 2007 revision. Population division of the Department of economic and social affairs, UN WashingtonGoogle Scholar
  80. Van den Born JA (2009) The drivers of career success of the job-hopping professional in the new networked economy; The challenges of being an entrepreneur and an employee. Ph.D Dissertation Utrecht University, Utrecht/Born to GrowGoogle Scholar
  81. Van Oort F, Lambooy J (2012, forthcoming) Cities, knowledge and innovation. In: Fischer M, Nijkamp P (eds) Handbook of regional science. Springer, BerlinGoogle Scholar
  82. Van Oort FG, Burger M, Knoben J, Raspe O (2012) Multilevel approaches and the firm-agglomeration ambiguity in economic growth studies. J Econ Surv 26:468–491CrossRefGoogle Scholar
  83. World Bank (2009) World Development Report: Reshaping economic geography. World Bank, Washington, DCGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Urban and Regional Research Center UtrechtUtrecht UniversityUtrechtThe Netherlands
  2. 2.Utrecht School o EconomicsUtrecht University UtrechtThe Netherlands

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