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Comparable clinical and functional outcomes after anterior cruciate ligament reconstruction over and under 40 years of age

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Knee Surgery, Sports Traumatology, Arthroscopy Aims and scope

Abstract

Purpose

The aim of the present meta-analysis was to update the literature on the outcomes and complications of ACL reconstruction in patients aged 40 years and older. It has been hypothesized that patients older than 40 years of age may have comparable clinical outcomes to those of younger patients.

Methods

A systematic review of articles from 1996 to 2018 was completed using Pubmed, Medline, Cochrane Reviews, and Google Scholar databases using the keyword terms “anterior cruciate ligament reconstruction” and “middle-aged OR elderly OR over 40 OR age factors.” Functional and clinical outcomes (International Knee Documentation Committee, Lysholm and Tegner score and KT-1000 arthrometer), complication and graft failure rate were evaluated.

Results

Eleven articles met inclusion criteria. In total, 306 middle-aged patients and 566 younger patients were included in this study. The mean age of patients > 40 was 49 ± 7 (range 40–75) years with a mean follow-up of 25 ± 9 months (range 12–68). The mean age of younger patients was 26 ± 2.7 (range 15–39) years with a mean post-operative follow-up of 26.7 ± 11.5 months (range 3–64). The results were slightly higher (but no significantly different) towards the younger group in terms of objective IKDC (P = n.s.), Lysholm (P = n.s.) and Tegner (P = n.s.) scores and knee laxity assessment (P = n.s.). Complication rate (P = n.s.) and graft failure (P = n.s.) were low even in this cohort.

Conclusions

The present meta-analysis shows that patients older than 40 years achieve comparable clinical outcomes to those of younger patients following primary ACL reconstruction. This evidence may push the surgeons toward a more aggressive approach in this specific cohort of patients.

Level of evidence

III.

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Authors and Affiliations

  1. Department of Medicine and Health Sciences “Vincenzo Tiberio”, University of Molise, Via Giovanni Paolo II, 86100, Campobasso, Italy

    Katia Corona & M. Ronga

  2. Sports Medicine Center, The Shoulder Center of Kentucky, Lexington, USA

    B. J. Morris

  3. 1a Clinica Ortopedica, ASST Centro Specialistico Ortopedico Traumatologico Gaetano Pini-CTO, Milan, Italy

    J. Tamini

  4. ASST Papa Giovanni XXIII, Bergamo, Italy

    G. Zappalà

  5. Department of Biotechnology and Lyfe Sciences (DBSV), University of Insubria, Varese, Italy

    M. Cherubino

  6. Casa di Cura Villa Betania, Rome, Italy

    S. Cerciello

  7. Marrelli Hospital, Crotone, Italy

    S. Cerciello

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  1. Katia Corona
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  2. M. Ronga
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  4. J. Tamini
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Correspondence to Katia Corona.

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Corona, K., Ronga, M., Morris, B.J. et al. Comparable clinical and functional outcomes after anterior cruciate ligament reconstruction over and under 40 years of age. Knee Surg Sports Traumatol Arthrosc 28, 1932–1945 (2020). https://doi.org/10.1007/s00167-019-05680-3

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  • DOI: https://doi.org/10.1007/s00167-019-05680-3

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