Patellofemoral pain syndrome
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The patellofemoral pain syndrome (PFPS) is a possible cause for anterior knee pain, which predominantly affects young female patients without any structural changes such as increased Q-angle or significant chondral damage. This literature review has shown that PFPS development is probably multifactorial with various functional disorders of the lower extremity. Biomechanical studies described patellar maltracking and dynamic valgus in PFPS patients (functional malalignment). Causes for the dynamic valgus may be decreased strength of the hip abductors or abnormal rear-foot eversion with pes pronatus valgus. PFPS is further associated with vastus medialis/vastus lateralis dysbalance, hamstring tightness or iliotibial tract tightness. The literature provides evidence for a multimodal non-operative therapy concept with short-term use of NSAIDs, short-term use of a medially directed tape and exercise programmes with the inclusion of the lower extremity, and hip and trunk muscles. There is also evidence for the use of patellar braces and foot orthosis. A randomized controlled trial has shown that arthroscopy is not the treatment of choice for treatment of PFPS without any structural changes. Patients with anterior knee pain have to be examined carefully with regard to functional causes for a PFPS. The treatment of PFPS patients is non-operative and should address the functional causes.
Level of evidence V.
KeywordsFunctional malalignment Dynamic valgus Hip strength Rear-foot eversion Single-leg squat Hip strength
The incidence of “anterior knee pain” is high and is located at 22/1,000 persons per year [12, 60]. Women are affected about more than twice as often as men [12, 29, 60]. The causes for anterior knee pain are multifactorial. These include overuse injuries of the extensor apparatus (tendonitis, insertional tendinosis), patellar instability, chondral and osteochondral damage .
The patellofemoral pain syndrome (PFPS) is a common cause for “anterior knee pain” and mainly affects young women without any structural changes such as increased Q-angle or significant pathological changes in articular cartilage [1, 12, 29, 52, 60]. Therefore, PFPS is a diagnosis of exclusion .
Other associated manifestations include crepitus and functional deficit . PFPS symptoms cause many athletes to limit their sportive activities . According to some authors, the PFPS will eventually lead to osteoarthritis [45, 64, 67].
The pathogenesis of PFPS is multifactorial with various functional disorders of the lower extremity to be involved .
Aim of this literature review is to summarize evidence regarding the underlying pathology of PFPS and the best way to treat this condition.
“Patella tracking” in patient with PFPS
The role of the patella maltracking for the emergence of the PFPS has long been a controversial issue.
Recent studies, however, show that maltracking of the patella probably plays a key role. Draper et al.  for example have demonstrated by dynamic MRI that patients with a PFPS squat with increased lateralization and increased lateral tilt of the patella. Witvrouw et al.  showed that a hypermobile patella had a significant correlation with the incidence of patellofemoral pain.
Role of M. vastus lateralis and M. vastus medialis
Pal et al.  have demonstrated that “patella maltracking” in patients with PFPS correlates with a delayed activation of the M. vastus medialis. An imbalance in the activation of the M. vastus medialis obliquus and M. vastus lateralis was also shown by Cowan et al. . In patients with a PFPS, the M. vastus lateralis was earlier activated than the M. vastus medialis obliquus when patients climbed downstairs and upstairs. In the control group that imbalance did not exist. These findings were supported by several other studies [15, 16, 74]. Patients with patellofemoral problems exhibited atrophy of the vastus medialis obliquus .
Despite these results, however, it is not clear whether the M. vastus lateralis and medialis imbalance are the primary cause for patellar maltracking.
Static or dynamic malalignment?
Some authors report that an increased Q-angle is associated with PFPS [39, 41]. For example, Rauh et al.  found that cross-country runners with increased Q-angle (>20°) are more prone to knee injury than athletes with normal Q-angle.
In contrast, Park et al.  have shown that the Q-angle is not increased in PFPS patients. Other reports also do not show strong correlations between static measures such as the Q-angle to the onset of PFPS .
Myer et al.  studied female middle and high school basketball players. In this study, athletes who developed a new PFPS demonstrated increased knee abduction moments of the symptomatic limb. That means there is a dynamic valgus position of the knee joint, which might be reinforced by an internal rotation of the femur and tibia (Fig. 2).
A dynamic valgus alignment is more frequently observed in female athletes compared to males [27, 28]. These biomechanical and neuromuscular mechanisms may be links to the pathogenesis of PFPS in young female athletes [35, 52, 56]. The functional or dynamic valgus may influence patella tracking leading to lateralization of the patella . Souza et al.  performed kinematic imaging of the patellofemoral joint using an open MRI to measure femur and patella rotation in PFPS patients. In this study, altered patellofemoral joint kinematics in females with PFPS was related to excessive medial rotation of the femur and lateral rotation of the patella .
Hip stability and hip abductor strength
Recent research has shown that functional malalignment does not arise in the knee joint but rather by internal rotation of the femur due to weakness of hip external rotators and abductors (M. gluteus medius and minimus) [2, 13, 14, 46, 57].
Padua et al.  found that decreased M. gluteus medius and M. gluteus maximus strength is related to increased knee valgus after landing a drop jump. Brent et al.  showed that females have decreased relative hip abduction strength in comparison with males. Decreased relative hip abduction strength has also been demonstrated in patients with PFPS [2, 13]. Bolgla et al.  showed that patients with a PFPS have a significant weakness of the external rotators of the hip. Baldon et al.  could also demonstrate that patients with PFPS have lower hip abduction strength.
All these studies are supported by a systematic review which demonstrated strong evidence that females with PFPS have a decreased hip abduction, external rotation and extension strength compared with healthy controls . This evidence does not exist for male PFPS patients.
A systematic review published by Barton et al.  has shown that patients with PFPS may have several disorders of the foot mechanics. These disorders include delayed timing of peak rear-foot eversion, increased rear-foot eversion at heel strike and reduced rear-foot eversion range .
Mølsgaard et al.  also could demonstrate abnormalities of the navicular bone in high school students with PFPS such as increased navicular drop, navicular drift and dorsiflexion.
Barton et al.  showed that PFPS patients have a more pronated foot type, increased forefoot abduction and increased rear-foot eversion in comparison with a healthy control group.
In conclusion, the literature provides evidence for rear-foot and forefoot abnormalities in PFPS patients.
Dynamic valgus may also have influence on the length of the iliotibial tract. Wu et al.  have shown that the iliotibial tract may also have an influence on patellar tracking. This may be anatomically explained by Kaplans fibres which connect the iliotibial tract with the patella. Other studies about the role of the iliotibial in PFPS patients are lacking.
Hamstring imbalance and tightness
There is some evidence in the literature that there is not only abnormal frontal plane knee motion in patients with PFPS.
Two studies identified a significant association between PFPS and hamstring tightness [47, 71]. These authors found significant hamstring tightness in patients relative to the control group. In another study, Patil et al.  showed by EMG that in patients with PFPS, the lateral hamstrings contracted earlier than the medial hamstrings during maximal arbitrary isometric contractions.
Besier et al.  have shown that patients with PFPS have greater co-contraction of the quadriceps and hamstrings compared to controls without symptoms of PFPS. In this study, females showed 30–50 % higher hamstring and gastrocnemius muscle forces during both walking and running compared to males. These authors concluded that by this mechanism, some PFPS patients might experience increased joint contact force and joint stress in comparison with healthy subjects.
All these changes can lead to high stress on the patella and its supporting structures.
“Knee-spine syndrome” 
Tsuji et al.  examined the correlation between patellofemoral joint pain, lumbar lordosis and sacral inclination, in elderly patients with anterior knee pain. There was a significant difference in sacral inclination between subjects with and without anterior knee pain . Inclination of the sacrum was less (app 5°) in patients with patellofemoral pain . This pathological concept was called the “knee-spine syndrome”.
For younger patients with PFPS, however, this mechanism has not been examined. More research is needed to elucidate the role of this mechanism for the pathogenesis of PFPS.
Psychological factors contributing to PFPS
Jensen et al.  have shown that pain and knee function can also be associated with psychological factors in some patients with long-lasting PFPS. These authors have shown that patients with PFPS have higher levels of mental distress in comparison with healthy subjects.
Thomee et al.  found that there are similarities regarding the pain experience and pain coping of PFPS patients to other groups of patients with chronic pain. In contrast to other chronic pain patients, higher scores were found on the Pain Catastrophizing Scale .
Domenech et al.  support the fear-avoidance model. This study demonstrated a high incidence of psychological distress such as anxiety and depression, pain catastrophizing and kinesophobia in PFPS patients. These factors were strong predictors of pain and disability in PFPS patients.
In some cases, the knee problems can be triggered by secondary disease profit . This may play a role in young competitive athletes, who are no longer capable of the increasing demands. The knee problems then may serve as an explanation for the stagnation or reduced performance .
Trigger for the PFPS
A possible trigger for the patellofemoral pain syndrome may be overload of the patellofemoral joint (e.g. high-intensity training). The combination of overload with dynamic valgus and functional lateralization of the patella may lead to overuse of the structures of the patellofemoral joint . This overload may cause anterior knee pain.
Anterior knee pain can be a vicious cycle. By anterior knee pain, the muscle activity of the lower extremity may be further inhibited.
Neurophysiological cause of pain in patients with PFPS
The exact cause of pain in patients with PFPS is unclear. Most probably the pain develops in the insertions of the extensor mechanism or within the subchondral bone .
Woitys et al.  observed substance P rich free nerve endings within the retinacula, Hoffa’s fad pad and subchondral bone.
Sanchis-Alfonso and Roselló-Sastre  observed a high expression of several neural markers such as neurofilament protein, S-100 protein, neural growth factor and substance P in the lateral retinacula of patients with patellofemoral maltracking. This study demonstrates that the innervation of the retinacula may play a role for the development of anterior knee pain. Sanchis-Alfonso  hypothesized that Sustance P and NGF expression may be related to mechanical stress within the retinacula. Patellar maltracking might be the cause for this abnormal stress .
In an experimental arthroscopy with local skin anaesthesia, S. Dye experienced strong pain when then probe touched the retinacula, Hoffas fad pad or the peripatella synovium .
However, there is additional evidence that the subchondral bone may also play a role for the origin of pain in PFPS patients. Draper et al.  have demonstrated increased metabolic bone activity in patients with PFPS using F NaF PET/CT.
Rathleff et al.  have shown that not only peripheral but also central mechanisms may cause pain in patients with PFPS. At the knee, adolescents with PFPS had a significantly lower pressure pain thresholds (localized hyperalgesia) compared with controls. On the tibialis anterior, however, adolescents with PFPS had also a lower pressure pain thresholds (distal hyperalgesia) compared with controls. Jensen et al.  could demonstrate an aberrant sensory function in PFPS patients. The mean detection threshold for temperature was significantly increased in PFPS patients compared to healthy controls.
Surgical versus conservative therapy
Kettunen et al.  have demonstrated in a prospective randomized study with PFPS patients that an arthroscopy, in combination with physiotherapy, had no positive effect compared to physiotherapy alone. Therefore, the treatment of PFPS is primarily non-operative.
A meta-analysis has shown that there is limited evidence for the effectiveness of non-steroidal anti-inflammatory drugs for reduction in acute anterior knee pain in PFPS patients . The findings regarding the efficacy of glycosamino-glycanpolysulfate and intraarticular application of corticoids are contradictory .
Pfeiffer et al.  demonstrated that a medially directed tape has the potential to correct lateral patella maltracking and patellar tilt. Gilleard et al.  showed that the M. vastus medialis obliquus (VMO) is activated earlier by application of a medially directed tape. Similar results were reported by Cowan et al. . According to Christou et al. , patients with patellofemoral pain syndrome had a higher VMO activity when a medially directed tape was applied.
Clinical studies could support these findings and showed that traditional medially directed tape has a positive effect on the symptoms of PFPS [22, 70]. Two meta-analyses were published evaluating the effect of tape on pain reduction in PFPS patients [22, 70]. One meta-analysis was published in 2002 and found that adhesive tape combined with exercise was significantly superior to an exercise programme alone regarding functional improvement and decrease in pain .
Another meta-analysis was published by Warden et al.  in 2008. This study showed that medially directed tape produces a clinically meaningful reduction in knee pain in patients with PFPS. This study, however, has also shown that even sham tape application has a positive effect on pain reduction in PFPS patients. Therefore, placebo, proprioceptive or sensory skin effects may contribute to the beneficial tape effects. The data analysis, however, revealed that these effects only explain approximately half of the pain reduction associated with medially directed tape only .
However, it should be noted that the tape effect on pain reduction has only been investigated in short-term studies (12-week follow-up). Long-term effects of tape on anterior knee pain have not been established. Therefore, the current evidence supports the use of tape as a temporary pain-relieving treatment of anterior knee pain in PFPS patients .
The positive influence of the tape on pain and function probably explains the synergistic effect of tape and physiotherapy. The simultaneous application of a restraining tape and a physiotherapy exercise programme achieved a better role as the sole tape system .
Patella braces are non-adhesive devices also applying an external medially directed force which may counteract lateral patella maltracking (Fig. 7).
Draper et al.  have demonstrated by real-time MRI that a knee brace which applies a medially directed force on the patella can reduce the lateralization of the patella and tilt in women with PFPS significantly better than a bandage. Powers et al.  analysed an orthosis which applied a medially directed force on the patella in PFPS patients. Theses authors found that pain was decreased and quadriceps activation was promoted.
According to the meta-analysis published by D’hondt et al. , the use of a patella brace has positive effects on pain, function (Kuala score) and the patellofemoral congruence angle as compared to a control group without the treatment. Due to the low quality of the studies, the authors concluded that this evidence should be regarded as limited.
Warden et al.  also found disputable evidence for the use of orthotics for PFPS patients. In this meta-analysis, only one of three studies found an effect of a medially directed patella brace, whereas in two studies, the effect was not significant. In these studies, no difference was found difference between orthoses which can apply a medially directed force on the patella and sham orthoses.
Therefore, we conclude that better designed studies should be performed to evaluate the effect of braces on pain and function in patients with PFPS.
Increased rear-foot eversion and pes pronatus can favour internal rotation and thus a dynamic valgus position of the lower extremity [3, 4, 5, 11, 44]. Therefore, insoles or foot orthotics could be a treatment option to correct the malalignment.
We found no meta-analysis analysing the effect of insoles on pain in PFPS patients and the studies from the literature report conflicting results.
Wiener-Ogilvie et al.  randomized PFPS patients to three different groups. These groups received either a foot orthoses alone, physiotherapy alone, or a combination of physiotherapy and foot orthoses. After a short-term follow-up, these authors found no significant difference in outcome among the three groups regarding pain levels or function.
In a prospective study, the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) significantly increased by the administration of a foot orthosis in patients with the combination of pes plano valgus, and patellofemoral pain syndrome after 2 weeks and 3 months .
Vicenzo et al.  published a prospective randomized trial involving 179 patients with a PFPS. Participating patients were divided into four different treatment groups: (1) foot orthosis, (2) a flat insert, (3) physiotherapy or (4) physiotherapy and a foot orthosis. Improvement for pain and function was found in all groups at 52 weeks, but there was no significant difference between the g treatment groups. In a post hoc subgroup analysis of the patients who received a foot orthosis, these authors found some predictors for the efficacy of foot orthoses in PFPS patients . These positive predictors were body height less than 165 cm, age older than 25, lower pain levels and midfoot abnormalities .
These findings may explain why other studies found an effect of foot orthosis on pain in PFPS patients. These studies, however, included patients with the combination of pes plano valgus and PFPS [7, 8, 9, 18].
Collins et al.  published a prospective randomized study involving 179 patients with PFPS and pes pronatus. These authors found that foot orthotics had the same effect as physical therapy. However, a synergistic effect of both therapies did not exist.
Barton et al.  examined the effect of prefabricated foot orthotics in patients with PFPS and pes plano valgus in a cohort study involving 60 patients. These authors could demonstrate that the use of a foot orthotic leads to pain reduction and improvements in functional parameters such as leg raise numbers and step down numbers. In another study, Barton et al.  could show that greater rear-foot eversion is a predictor for the efficacy of foot orthotics in individuals with PFPS. In another study, the quality of life of patients with the combination of PFPS and pes plano valgus could be improved through the use of foot orthotics .
Therefore, foot orthosis might be a treatment option for patients with the combination of disorders of foot posture and PFPS. However, more well-designed studies are needed to examine the efficacy of foot orthoses and to identify subgroup patients which would benefit from the treatment with foot orthoses.
Physiotherapy is the most frequently studied form of therapy for PFPS . Two meta-analyses have been published.
In 2003, Heintjes et al.  published a Cochrane review about exercise for PFPS. This meta-analysis identified one high- and two low-quality studies comparing exercise with a control group without exercise. This meta-analysis reported the positive effects for pain reduction for patients treated with exercise. One of the low-quality studies even reported also functional improvement in the exercise groups.
In a more recent meta-analysis published in 2008, 10 prospective randomized studies could be analysed . All these studies showed a positive effect of exercise on pain reduction. Positive results have been described in particular with active stretching exercises, squats, ergometer, static quadriceps exercises, active leg raises, leg press, raising and lowering climbing exercises. Four of the exercise programme also included exercises to strengthen the hip abductors. In one study, trunk-stabilizing exercises, including the rectus abdominis, were analysed. The most frequent duration of the exercise programmes was 6 weeks. The exercises were conducted two-to-four times daily with 10 repetitions. Closed- and open-chain exercises, balance training and proprioceptive exercises have been described. Eight studies also included stretching exercises. In 8 studies, additional interventions such as restriction of symptom inducing activities, tape, braces and NSAIDs were allowed.
Conclusions and future strategies
The patellofemoral pain syndrome is a clinical entity which leads to anterior knee pain in patients without any pathological changes at the cartilage of the patellofemoral joint. Patellar maltracking due to a functional malalignment or dynamic valgus may be an underlying cause for this clinical entity. Possible causes for the dynamic valgus may be decreased strength of the hip abductors or a pes pronatus valgus. The functional malalignment is associated with quadriceps dysbalance, hamstring tightness or iliotibial tract tightness. The clinical usefulness of these findings is that a physician may tailor an individual treatment plan for each patient according to the underlying pathology. However, there is a clear need for further research to distinguish between cause and effect.
The literature provides evidence for a multimodal non-operative therapy concept with short-term use of NSAIDs, short-term use of a medially directed tape and complex exercise programmes with the inclusion of the lower extremity, and hip and trunk muscles. There is also evidence for the use of patellar braces and foot orthosis. There is need for further studies about braces and foot orthosis.
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