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Immersed boundary-finite element model of fluid–structure interaction in the aortic root

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Abstract

It has long been recognized that aortic root elasticity helps to ensure efficient aortic valve closure, but our understanding of the functional importance of the elasticity and geometry of the aortic root continues to evolve as increasingly detailed in vivo imaging data become available. Herein, we describe a fluid–structure interaction model of the aortic root, including the aortic valve leaflets, the sinuses of Valsalva, the aortic annulus, and the sinotubular junction, that employs a version of Peskin’s immersed boundary (IB) method with a finite element description of the structural elasticity. As in earlier work, we use a fiber-based model of the valve leaflets, but this study extends earlier IB models of the aortic root by employing an incompressible hyperelastic model of the mechanics of the sinuses and ascending aorta using a constitutive law fit to experimental data from human aortic root tissue. In vivo pressure loading is accounted for by a backward displacement method that determines the unloaded configuration of the root model. Our model yields realistic cardiac output at physiological pressures, with low transvalvular pressure differences during forward flow, minimal regurgitation during valve closure, and realistic pressure loads when the valve is closed during diastole. Further, results from high-resolution computations indicate that although the detailed leaflet and root kinematics show some grid sensitivity, our IB model of the aortic root nonetheless produces essentially grid-converged flow rates and pressures at practical grid spacings for the high Reynolds number flows of the aortic root. These results thereby clarify minimum grid resolutions required by such models when used as stand-alone models of the aortic valve as well as when used to provide models of the outflow valves in models of left-ventricular fluid dynamics.

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Authors and Affiliations

  1. Department of Mechanical and Aerospace Engineering, New York University Tandon School of Engineering, Brooklyn, NY, USA

    Vittoria Flamini

  2. Division of Cardiothoracic Surgery, Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA

    Abe DeAnda

  3. Departments of Mathematics and Biomedical Engineering and McAllister Heart Institute, University of North Carolina, Phillips Hall, Campus Box 3250, Chapel Hill, NC, USA

    Boyce E. Griffith

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  1. Vittoria Flamini
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Flamini, V., DeAnda, A. & Griffith, B.E. Immersed boundary-finite element model of fluid–structure interaction in the aortic root. Theor. Comput. Fluid Dyn. 30, 139–164 (2016). https://doi.org/10.1007/s00162-015-0374-5

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