Zusammenfassung
Knorpelgewebe besitzt keine Fähigkeit zur Eigenregeneration, sodass die chirurgische Knorpeltherapie ein essenzielles Verfahren in der Behandlung von Knorpelschäden darstellt. Die Indikation richtet sich nicht nur nach der Größe und morphologischen Beschaffenheit des Schadens, sondern insbesondere nach der klinischen Symptomatik. Die Mikrofrakturierung stellt ein validiertes Verfahren für kleine Defekte dar, ist jedoch der autologen Chondrozytentransplantation (ACT/MACT) in der histologischen Qualität etwas unterlegen. Die ACT/MACT kann mittlerweile in offener und rein arthroskopischer Technik angewendet werden und ist der Mikrofrakturierung hinsichtlich der klinischen Behandlungsergebnisse ebenbürtig bzw. bei großen Defekten sogar überlegen. Nachteilig ist jedoch weiterhin das notwendige zweizeitige Verfahren. Zellfreie Behandlungsmethoden bieten daher als einzeitige Verfahren eine gute Alternative und zeigten in ersten Studien vielversprechende Ergebnisse. Systematische Langzeitstudien und randomisierte Studien sind jedoch notwendig, um das Potenzial dieser Behandlungsstrategien zu evaluieren und sie mit traditionellen Therapiealternativen suffizient vergleichen zu können. Begleitpathologien bzw. Risikofaktoren müssen in der chirurgischen Knorpeltherapie unbedingt beachtet und ggf. mit therapiert werden.
Abstract
Cartilage tissue does not have the ability for self-regeneration, making surgical cartilage treatment an essential procedure in the treatment of chondral damage. The indications are based not only on the size and morphological nature of the damage but also especially on the clinical symptoms. Microfracturing represents a validated procedure for small defects but is slightly inferior to autologous chondrocyte transplantation (ACT/MACT) in histological quality. The ACT/MACT can now be used in an open and purely arthroscopic technique and is equal to microfracturing in terms of clinical treatment results and even superior for large defects; however, the disadvantage is still the necessary 2‑step process. Cell-free treatment methods therefore offer a suitable alternative as a 1-step procedure and have shown promising results in initial studies. Systematic long-term studies and randomized trials are still needed to evaluate the potential of these treatment strategies and to sufficiently compare them with traditional alternative forms of treatment. Strict attention must be paid to concomitant pathologies and risk factors in surgical cartilage treatment and, if necessary, also be treated.
Literatur
Brower TD, Hsu WY (1969) Normal articular cartilage. Clin Orthop Relat Res 64:9–17
Rath B et al (2017) Cartilage repair of the knee joint. Orthopade 46(11):919–927. https://doi.org/10.1007/s00132-017-3463-x
Devitt BM et al (2017) Surgical treatments of cartilage defects of the knee: systematic review of. Knee 24(3):508–517. https://doi.org/10.1016/j.knee.2016.12.002
Schenker H et al (2017) Current overview of cartilage regeneration procedures. Orthopade 46(11):907–913. https://doi.org/10.1007/s00132-017-3474-7
Huber M, Trattnig S, Lintner F (2000) Anatomy, biochemistry, and physiology of articular cartilage. Invest Radiol 35(10):573–580
Welton KL et al (2018) Knee cartilage repair and restoration: common problems and solutions. Clin Sports Med 37(2):307–330. https://doi.org/10.1016/j.csm.2017.12.008
Brittberg M et al (2016) Cartilage repair in the degenerative ageing knee. Acta Orthop 87(sup363):26–38. https://doi.org/10.1080/17453674.2016.1265877
Braun S, Vogt S, Imhoff AB (2007) Stage oriented surgical cartilage therapy. Current situation. Orthopade 36(6):589–599 (quiz 600)
Knutsen G et al (2016) A randomized multicenter trial comparing autologous chondrocyte implantation with microfracture. Findings at 14 to 15 years. J Bone Joint Surg Am 98(16):1332–1339. https://doi.org/10.2106/JBJS.15.01208
Steadman JR et al (1999) The microfracture technic in the management of complete cartilage defects in the knee. Orthopade 28(1):26–32
Shapiro F, Koide S, Glimcher MJ (1993) Cell origin and differentiation in the repair of full-thickness defects of articular cartilage. J Bone Joint Surg Am 75(4):532–553
Flanigan DC et al (2010) The effects of lesion size and location on subchondral bone contact in experimental knee articular cartilage defects in a bovine model. Arthroscopy 26(12):1655–1661. https://doi.org/10.1016/j.arthro.2010.05.017
Knutsen G et al (2007) A randomized trial comparing autologous chondrocyte implantation with microfracture. Findings at five years. J Bone Joint Surg Am 89(10):2105–2112
Vanlauwe J et al (2011) Five-year outcome of characterized chondrocyte implantation versus microfracture. Am J Sports Med 39(12):2566–2574. https://doi.org/10.1177/0363546511422220
Oussedik S, Tsitskaris K, Parker D (2015) Treatment of articular cartilage lesions of the knee by microfracture or autologous chondrocyte implantation: a systematic review. Arthroscopy 31(4):732–744. https://doi.org/10.1016/j.arthro.2014.11.023
Aldrian S et al (2014) Clinical and radiological long-term outcomes after matrix-induced autologous chondrocyte transplantation: a prospective follow-up at a minimum of 10 years. Am J Sports Med 42(11):2680–2688. https://doi.org/10.1177/0363546514548160
Nawaz SZ et al (2014) Autologous chondrocyte implantation in the knee: mid-term to long-term results. J Bone Joint Surg Am 96(10):824–830. https://doi.org/10.2106/JBJS.L.01695
Zak L et al (2014) Results 2 years after matrix-associated autologous ahondrocyte transplantation using the Novocart 3D scaffold: an analysis of clinical and radiological data. Am J Sports Med 42(7):1618–1627. https://doi.org/10.1177/0363546514532337
Brittberg M et al (1994) Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med 331(14):889–895
Saris D et al (2014) Matrix-applied characterized autologous cultured chondrocytes versus microfracture: two-year follow-up of a prospective randomized trial. Am J Sports Med 42(6):1384–1394. https://doi.org/10.1177/0363546514528093
Crawford DC, DeBerardino TM, Williams RJ 3rd (2012) NeoCart, an autologous cartilage tissue implant, compared with microfracture for treatment of distal femoral cartilage lesions: an FDA phase-II prospective, randomized clinical trial after two years. J Bone Joint Surg Am 94(11):979–989. https://doi.org/10.2106/JBJS.K.00533
Redondo ML, Beer AJ, Yanke AB (2018) Cartilage restoration: microfracture and osteochondral autograft transplantation. J Knee Surg 31(3):231–238. https://doi.org/10.1055/s-0037-1618592
Gille J et al (2010) Mid-term results of autologous matrix-induced chondrogenesis for treatment of focal cartilage defects in the knee. Knee Surg Sports Traumatol Arthrosc 18(11):1456–1464
Schiavone Panni A, Cerciello S, Vasso M (2011) The manangement of knee cartilage defects with modified amic technique: preliminary results. Int J Immunopathol Pharmacol 24(1 Suppl 2):149–152
Dhollander AA et al (2011) Autologous matrix-induced chondrogenesis combined with platelet-rich plasma gel: technical description and a five pilot patients report. Knee Surg Sports Traumatol Arthrosc 19(4):536–542
Pascarella A et al (2010) Treatment of articular cartilage lesions of the knee joint using a modified AMIC technique. Knee Surg Sports Traumatol Arthrosc 18(4):509–513
Kusano T et al (2012) Treatment of isolated chondral and osteochondral defects in the knee by autologous matrix-induced chondrogenesis (AMIC). Knee Surg Sports Traumatol Arthrosc 20(10):2109–2115
Efe T et al (2012) Cell-free collagen type I matrix for repair of cartilage defects-clinical and magnetic resonance imaging results. Knee Surg Sports Traumatol Arthrosc 20(10):1915–1922
Roessler PP et al (2015) Short-term follow up after implantation of a cell-free collagen type I matrix for the treatment of large cartilage defects of the knee. Int Orthop. https://doi.org/10.1007/s00264-015-2695-9
Steinwachs MR, Waibl B, Mumme M (2014) Arthroscopic treatment of cartilage lesions with Microfracture and BST-cargel. Arthrosc Tech 3(3):e399–e402
Stanish WD et al (2013) Novel scaffold-based BST-CarGel treatment results in superior cartilage repair compared with microfracture in a randomized controlled trial. J Bone Joint Surg Am 95(18):1640–1650
Shive MS et al (2015) BST-CarGel(R) treatment maintains cartilage repair superiority over Microfracture at 5 years in a Multicenter randomized controlled trial. Cartilage 6(2):62–72
Methot S et al (2016) Osteochondral biopsy analysis demonstrates that BST-cargel treatment improves. Cartilage 7(1):16–28. https://doi.org/10.1177/1947603515595837
McDonald LS et al (2016) ACL deficiency increases forces on the medial femoral condyle and the lateral meniscus. J Bone Joint Surg Am 98(20):1713–1721
Siebold R, Karidakis G, Fernandez F (2014) Clinical outcome after medial patellofemoral ligament reconstruction and autologous chondrocyte implantation following recurrent patella dislocation. Knee Surg Sports Traumatol Arthrosc 22(10):2477–2483. https://doi.org/10.1007/s00167-014-3196-x
Goebel L, Reinhard J, Madry H (2017) Meniscal lesion. A pre-osteoarthritic condition of the knee joint. Orthopade 46(10):822–830. https://doi.org/10.1007/s00132-017-3462-y
Niethammer TR et al (2015) Bone Marrow Edema in the Knee and Its Influence on Clinical Outcome After Matrix-Based Autologous Chondrocyte Implantation: Results After 3‑Year Follow-up. Am J Sports Med 43(5):1172–1179. https://doi.org/10.1177/0363546515573935
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Interessenkonflikt
F. Blanke und S. Vogt geben an, dass kein Interessenkonflikt besteht.
Für diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.
Rights and permissions
About this article
Cite this article
Blanke, F., Vogt, S. Regeneration artikulärer Knorpeldefekte am Kniegelenk. Arthroskopie 32, 182–186 (2019). https://doi.org/10.1007/s00142-019-0277-3
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00142-019-0277-3
Schlüsselwörter
- Knorpeltherapie
- Knorpelschaden
- Matrixgestützte autologe Chondrozytentransplantation
- Mikrofrakturierung
- Zellfreie Therapieverfahren