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Dear Editor,
We are grateful to Dr. Saleh for his comments [1] regarding our paper on central venous pressure (CVP) [2]. Many of his points are well taken, including the notion that the concept of fluid responsiveness and fluid therapy in general needs to be evidence-based.
Our results may only be interpreted in the context of fluid responsiveness. Thus, if clinicians use CVP to predict fluid responsiveness, it is likely that the predictive power is low [2].
There is an urgent need for trials with low risk of bias assessing the benefit vs harm of different strategies for fluid therapy in different patient categories in different settings.
References
Saleh AS (2016) Is the concept of fluid responsiveness evidence-based? Intensive Care Med. doi:10.1007/s00134-016-4306-7
Eskesen TG, Wetterslev M, Perner A (2015) Systematic review including re-analyses of 1148 individual data sets of central venous pressure as a predictor of fluid responsiveness. Intensive Care Med 42:324–332
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Perner, A. Is the concept of fluid responsiveness evidence-based? Response to comments by Saleh. Intensive Care Med 42, 1189 (2016). https://doi.org/10.1007/s00134-016-4361-0
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DOI: https://doi.org/10.1007/s00134-016-4361-0