Skip to main content
Log in

Periradikuläre Infiltrationstherapie

Klinische Indikationen, Technik und Ergebnisse

Periradicular infiltration therapy

Clinical indications, technique and results

  • Leitthema
  • Published:
Der Radiologe Aims and scope Submit manuscript

Zusammenfassung

Hintergrund

Minimal-invasive schmerztherapeutische Verfahren werden in den letzten Jahren zunehmend angewendet.

Ziel der Arbeit

Evaluation der verschiedenen Verfahren der periradikulären Infiltrationstherapie als wichtiges Instrumentarium im Stufenkonzept der modernen Schmerztherapie. Vergleich der unterschiedlichen therapeutischen Substanzen.

Ergebnisse

Die periradikuläre Infiltrationstherapie ist bei rund 60–80 % der Patienten sowohl analgetisch als auch funktionell mittel- und langfristig wirksam. Die Einhaltung der Richtlinien soll potenziell fatale Komplikationen minimieren.

Schlussfolgerung

Die periganglionäre Infiltration hat einen anerkannt hohen Stellenwert in der Behandlung des radikulären Wurzelreizsymptoms. Die Infiltrationen gelten als risikoarme Verfahren insbesondere bei CT-gezielter Applikation.

Abstract

Background

Minimally invasive procedures have played an emerging role in pain management during recent years.

Objectives

Evaluation of the different types of periradicular infiltration as fundamental procedures in the progressive stepwise concept of pain management. Comparison of the different therapeutic substances.

Results

In the mid-term and long-term periradicular infiltration is effective in 60–80 % of patients regarding analgesic and functional aspects. Compliance with the guidelines should help to minimize potentially fatal complications.

Conclusion

Periradicular infiltration is of significant importance concerning the treatment of spinal nerve root irritation. Periradicular infiltration is regarded as a safe procedure, especially when supported by computed tomography (CT) scans.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abb. 1
Abb. 2
Abb. 3

Literatur

  1. Andreula CF, Simonetti L, De Santis F, Agati R, Ricci R, Leonardi M (2003) Minimally invasive oxygen-ozone therapy for lumbar disk herniation. Ajnr Am J Neuroradiol 24:996–1000

    PubMed  Google Scholar 

  2. Benny B, Azari P (2011) The efficacy of lumbosacral transforaminal epidural steroid injections: a comprehensive literature review. J Back Musculoskelet Rehabil 24(2):67–76

    PubMed  Google Scholar 

  3. Bensler S, Sutter R, Pfirrmann CW, Peterson CK (2015) Long term outcomes from CT-guided indirect cervical nerve root blocks and their relationship to the MRI findings- a prospective study. Eur Radiol 23 (Epub ahead of print)

    Google Scholar 

  4. Benzon HT, Huntoon MA, Rathmell JP (2015) Improving the safety of epidural steroid injections. JAMA 313(17):1713–1714

    Article  PubMed  Google Scholar 

  5. Bonetti M, Fontana A, Cotticelli B, Volta GD, Guindani M, Leonardi M (2005) Intraforaminal O(2)-O(3) versus periradicular steroidal infiltrations in lower back pain: randomized controlled study. Ajnr Am J Neuroradiol 26(5):996–1000

    PubMed  Google Scholar 

  6. Borghi B, Aurini L, White PF, Mordenti A, Lolli F, Borghi R, Martignani M, Greggi T (2013) Long-lasting beneficial effects of periradicular injection of meloxicam for treating chronic low back pain and sciatica. Minerva Anestesiol 79(4):370–378

    CAS  PubMed  Google Scholar 

  7. Burke JG, Watson RW, McCormack D, Dowling FE, Walsh MG, Fitzpatrick JM (2002) Intervertebral discs which cause low back pain secrete high levels of proinflammatory mediators. J Bone Joint Surg Br 84:196–201

    Article  CAS  PubMed  Google Scholar 

  8. Bush K, Hillier S (1996) Outcome of cervical radiculopathy treated with periradicular/epidural corticosteroid injections: a prospective study with independent clinical review. Eur Spine J 5(5):319–325

    Article  CAS  PubMed  Google Scholar 

  9. Cohen SP (2015) Epidemiology, diagnosis, and treatment of neck pain. Mayo Clin Proc 90(2):284–299

    Article  PubMed  Google Scholar 

  10. Costa LC, Maher CG, McAuley JH, Hancock MJ, Herbert RD, Refshauge KM, Henschke N (2009) Prognosis for patients with chronic low back pain: inception cohort study. BMJ 339:b3829

    Article  PubMed Central  Google Scholar 

  11. Croft PR, Macfarlane GJ, Papageorgiou AC, Thomas E, Silman AJ (1998) Outcome of low back pain in general practice: a prospective study. BMJ 316:1356–1359

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  12. Cyteval C, Eric T, Eric D, Sarrabere MP, Cottin A, Blotman F, Taourel P (2004) Cervical radiculopathy: open study on percutaneous periradicular foraminal steroid infiltration performed under CT control in 30 patients. AJNR 25:441–445

    PubMed  Google Scholar 

  13. Czervionke LF, Haughton VM (2002) Degenerative disease of the spine. In: Atlas SW (ed) magnetic resonance imaging of the brain and spine. Lippincott Williams Wilkins, Philadelphia Baltimore New York, S 1633–1713

    Google Scholar 

  14. Deml MC, Buhr M, Wimmer MD, Pflugmacher R, Riedel R, Rommelspacher Y, Kabir K (2015) CT-guided infiltration saves surgical intervention and fastens return to work compared to anatomical landmark-guided infiltration in patients with lumbosciatica. Eur J Orthop Surg Traumatol 25(Suppl 1):177–182

    Article  Google Scholar 

  15. Desai A, Saha S, Sharma N, Huckerby L, Houghton R (2014) The short- and medium-term effectiveness of CT-guided selective cervical nerve root injection for pain and disability. Skelet Radiol 43(7):973–978

    Article  Google Scholar 

  16. Deyo RA, Weinstein JN (2001) Low Back Pain. N Engl J Med 344(5):363–370

    Article  CAS  PubMed  Google Scholar 

  17. El Abd O, Amadera JE, Pimentel DC, Gomba L (2015) Immediate and acute adverse effects following transforaminal epidural steroid injections with dexamethasone. Pain Physician 18(3):277–286

    PubMed  Google Scholar 

  18. Fejer R, Kyvik KO, Hartvigsen J (2006) The prevalence of neck pain in the world population: a systematic critical review of the literature. Eur Spine J 15(6):834–848

    Article  PubMed Central  PubMed  Google Scholar 

  19. Fernández-de-las-Peñas C, Hernández-Barrera V, Alonso-Blanco C, Palacios-Ceña D, Carrasco-Garrido P, Jiménez-Sánchez S, Jiménez-García R (2011) Prevalence of neck and low back pain in community-dwelling adults in Spain: a population-based national study. Spine 36(3):E213–9 (Phila Pa 1976)

    Article  PubMed  Google Scholar 

  20. Friedly JL, Comstock BA, Turner JA, Heagerty PJ, Deyo RA et al (2014) A randomized trial of epidural glucocorticoid iinjectins in spinal stenosis: local anesthetic alone vs. local combined with steroids. N Engl J Med 12:214–222

    Google Scholar 

  21. Glaser SE, Falco F (2005) Paraplegia following a thoracolumbar transforaminal epidural steroid injection. Pain Physician 8(3):309–314

    PubMed  Google Scholar 

  22. Hodler J, Boos N, Schubert M (2013) Must we discontinue selective cervical nerve root blocks? Report of two cases and review of the literature. Eur Spine J 22(Suppl 3):466–470

    Article  PubMed Central  Google Scholar 

  23. Hogg-Johnson S, van der Velde G, Carroll LJ et al (2008) The burden and determinants of neck pain in the general population: results of the bone and joint decade 2000-2010 Task Force on neck pain and its associated disorders. Spine 33(Suppl 4):S39–S51 (Phila Pa 1976)

    Article  PubMed  Google Scholar 

  24. Hooten WM, Mizerak A, Carns PE, Huntoon MA (2006) Discitis after lumbar epidural corticosteroid injection: a case report and analysis of the case report literature. Pain Med 7(1):46–51

    Article  PubMed  Google Scholar 

  25. Kääriä S, Laaksonen M, Rahkonen O, Lahelma E, Leino-Arjas P (2012) Risk factors of chronic neck pain: a prospective study among middle-aged employees. Eur J Pain 16(6):911–920

    Article  PubMed  Google Scholar 

  26. Karppinen J, Malmivaara A, Kurunlahti M, Kyllönen E, Pienimäki T, Nieminen P, Ohinmaa A, Tervonen O, Vanharanta H (2001) Periradicular infiltration for sciatica: a randomized controlled trial. Spine 26:1059–1067

    Article  CAS  PubMed  Google Scholar 

  27. Kelekis A, Filippiadis DK, Velonakis G, Martin JB, Oikonomopoulos N, Brountzos E, Kelekis N (2014) Fluoroscopically guided infiltration of the cervical nerve root: an indirect approach through the Ipsilateral facet joint. Pain Physician 17:291–296

    PubMed  Google Scholar 

  28. Kennedy DJ, Dreyfuss P, Aprill CN, Bogduk N (2009) Paraplegia following image-guided transforaminal lumbar spine epidural steroid injection: two case reports. Pain Med 10(8):1389–1394

    Article  PubMed  Google Scholar 

  29. Kennedy DJ, Plastaras C, Casey E, Visco CJ, Rittenberg JD, Conrad B, Sigler J, Dreyfuss P (2014) Comparative effectiveness of lumbar transforaminal epidural steroid injections with particulate versus nonparticulate corticosteroids for lumbar radicular pain due to intervertebral disc herniation: a prospective, randomized, double-blind trial. Pain Med 15(4):548–555

    Article  PubMed  Google Scholar 

  30. Kolstad F, Leivseth G, Nygaard OP (2005) Transforaminal steroid injections in the treatment of cervical radiculopathy. A prospective outcome study. Acta Neurochir 147:1065–1070

    Article  CAS  PubMed  Google Scholar 

  31. Lange A, Eckardt A (2011) Injektionsverfahren an der Lendenwirbelsäule. In: Eckardt A (Hrsg) Praxis LWS-Erkrankungen. Diagnose und Therapie. Springer Verlag, Berlin, S 186–242

    Google Scholar 

  32. Lehnert T, Naguib NN, Wutzler S, Nour-Eldin NE, Bauer RW, Kerl JM, Vogl TJ, Balzer JO (2012) Analysis of disk volume before and after CT-guided intradiscal and periganglionic ozone-oxygen injection for the treatment of lumbar disk herniation. J Vasc Interv Radiol 23(11):1430–1436

    Article  PubMed  Google Scholar 

  33. Manchikanti L, Pampati V, Benyamin RM, Boswell MV (2015) Analysis of efficacy differences between caudal and lumbar interlaminar epidural injections in chronic lumbar axial discogenic pain: local anesthetic alone vs. local combined with steroids. Intern J Med Sci 12:214–222

    Article  Google Scholar 

  34. Manchikanti L, Atluri AS, Benyamin RM, Boswell MV, Buenaventura RM et al (2013) An update of comprehensive evidence-based guidelines for interventional techniques in chronic spinal pain. Part II: guidance and recommendations. Pain Physician 16(Suppl 2):49–283

    Google Scholar 

  35. Manchikanti L, Candido KD, Kaye AD, Boswell MV, Benyamin RM et al (2014) Randomized trial of epidural injections for spinal etenosis published in the new england journal of medicine: further confusion without clarification. Pain Physician 17:E475–487

    PubMed  Google Scholar 

  36. Manchikanti L, Kaye AD, Manchikanti K, Boswell M, Pampati V, Hirsch J (2015) Efficacy of epidural injections in the treatment of lumbar central stenosis. A systematic review. Anesth Pain Med 5(1):e23139

    Article  PubMed Central  PubMed  Google Scholar 

  37. Manchikanti L, Nampiaparampil DE, Candido KD, Bakshi S, Grider JS, Falco F, Sehgal N, Hirsch JA (2015) Do cervical epidural injections provide long-term relief in neck and upper extremity pain? A systematic review. Pain Physician 18:39–60

    PubMed  Google Scholar 

  38. Manchikanti L, Singh V, Falco FJ, Benyamin RM, Hirsch JA (2014) Epidemiology of low back pain in adults. Neuromodulation17 Suppl 2:3–10

    Article  Google Scholar 

  39. McCormick Z, Kennedy DJ, Garvan C, Rivers E, Temme K, Margolis S, Zander E, Rohr A, Smith MC, Plastaras C (2015) Comparison of pain score reduction using triamcinolone vs. betamethasone in transforaminal epidural steroid injections for lumbosacral radicular pain. Am J Phys Med Rehabil (Epub ahead of print). DOI: 10.1097/PHM.0000000000000296

  40. Muto M, Andreula C, Leonardi M (2004) Treatment of herniated lumbar disc by intradiscal and intraforaminal oxygen-ozone (O2-O3) injection. J Neuroadiology 31:183–189

    Article  CAS  Google Scholar 

  41. Muto M, Andreula C, Leonardi M (2004) Treatment of herniated lumbar disc by intradiscal and intraforaminal oxygen-ozone (O2-O3) injection. J Neuroradiol 31(3):183–189

    Article  CAS  PubMed  Google Scholar 

  42. Ng L, Chaudhary N, Sell P (2005) The efficacy of corticosteroids in periradicular infiltration for chronic radicular pain: a randomized, double-blind, controlled trial. Spine 30:857–862

    Article  PubMed  Google Scholar 

  43. Oder B, Loewe M, Reisegger M, Lang W, Ilias W, Thurnher SA (2008) CT-guided ozone/steroid therapy for the treatment of degenerative spinal disease - effect of age, gender, disc pathology and multi-segmental changes. Neuroradiology 50(9):777–785

    Article  PubMed  Google Scholar 

  44. Peng B, Hou S, Wu W, Zhang C, Yang Y (2006) The pathogenesis and clinical significance of a high-intensity zone (HIZ) of lumbar intervertebral disc on MR imaging in the patient with discogenic low back pain. Eur Spine J 15:583–587

    Article  PubMed Central  PubMed  Google Scholar 

  45. Pobiel RS, Schellhas KP, Eklund JA, Golden MJ, Johnson BA, Chopra S, Broadbent P, Myers ME, Shrack K (2009) Selective cervical nerve root blockade: prospective study of immediate and longer term complications. Ajnr Am J Neuroradiol 30(3):507–511

    Article  CAS  PubMed  Google Scholar 

  46. Radhakrishnan K, Litchy WJ, O’Fallon WM, Kurland LT (1994) Epidemiology of cervical radiculopathy. A population-based study from Rochester, Minnesota, 1976 through 1990. Brain 117(Pt 2):325–335

    Article  PubMed  Google Scholar 

  47. Shiri R, Lallukka T, Karppinen J, Viikari-Juntura E (2014) Obesity as a risk factor for sciatica: a meta-analysis. Am J Epidemiol 179(8):929–937

    Article  PubMed  Google Scholar 

  48. Stein V, Greitemann B, Bork H (2014) Leitlinie zur konservativen und rehabilitativen Versorgung bei Bandscheibenvorfheibenvorfradikulk H. Symptomatik 2:052k H

  49. Strine TW, Hootman JM (2007) US national prevalence and correlates of low back and neck pain among adults. Arthritis Rheum 57(4):656–665

    Article  PubMed  Google Scholar 

  50. Strobel K, Pfirrmann CW, Schmid M, Hodler J, Boos N, Zanetti M (2004) Cervical nerve root blocks: indications and role of MR imaging. Radiology 233(1):87–92

    Article  PubMed  Google Scholar 

  51. Sutter R, Pfirrmann CW, Zanetti M, Hodler J, Peterson CK (2011) CT-guided cervical nerve root injections: comparing the immediate post-injection anesthetic-related effects of the transforaminal injection with a new indirect technique. Skelet Radiol 40(12):1603–1608

    Article  Google Scholar 

  52. Taskaynatan MA, Tezel K, Yavuz F, Tan AK (2014) The effectiveness of transforaminal epidural steroid injection in patients with radicular low back pain due to lumbar disc herniation two years after treatment. J Back Musculoskelet Rehabil 15 (Epub ahead of print). DOI: 10.3233/BMR-140539

  53. Verkerk K, Luijsterburg PA, Heymans MW, Ronchetti I, Pool-Goudzwaard AL, Miedema HS, Koes BW (2013) Prognosis and course of disability in patients with chronic nonspecific low back pain: a 5- and 12-month follow-up cohort study. Phys Ther 93(12):1603–1614

    Article  PubMed  Google Scholar 

  54. Waggershauser T, Schwarzkopf S, Reiser M (2006) Facet blockade, peridural and periradicular pain therapy. Radiologe 46(6):520–526

    Article  CAS  PubMed  Google Scholar 

  55. Wewalka M, Abdelrahimsai A, Wiesinger GF, Uher EM (2012) CT-guided transforaminal epidural injections with local anesthetic, steroid, and tramadol for the treatment of persistent lumbar radicular pain. Pain Physician 15(2):153–159

    PubMed  Google Scholar 

  56. Wheeler AH, Murrey DB (2002) Chronic lumbar spine and radicular pain: Pathophysiolog and treatment. Curr Pain Headache Rep 6:97–105

    Article  PubMed  Google Scholar 

  57. Yoo HS, Park SW, Han JH, Chung JY, Yi JW, Kang JM, Lee BJ, Kim DO (2009) Paraplegia caused by an epidural hematoma in a patient with unrecognized chronic idiopathic thrombocytopenic purpura following an epidural steroid injection. Spine 34(10):E376–9 (Phila Pa 1976)

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to B. Oder.

Ethics declarations

Interessenkonflikt

B. Oder und S. Thurnher geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Oder, B., Thurnher, S. Periradikuläre Infiltrationstherapie. Radiologe 55, 833–839 (2015). https://doi.org/10.1007/s00117-015-0017-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00117-015-0017-2

Schlüsselwörter

Keywords

Navigation