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Influence of hyperhomocysteinemia on left ventricular diastolic function in Chinese patients with hypertension

Einfluss der Hyperhomozysteinämie auf die linksventrikuläre diastolische Funktion bei chinesischen Hypertoniepatienten

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Abstract

Objective

The aim of this study was to assess the effect of plasma homocysteine (Hcy) on left ventricular (LV) diastolic function in Chinese patients with essential hypertension.

Patients and methods

A total of 74 patients with hypertension were enrolled in the present study and were divided into two groups according to the plasma levels of Hcy: high levels of Hcy (Hhcy) group (n = 37) and control group (n = 37) with normal levels of homocysteine. The study participants consisted of 37 hypertensive patients with Hhcy and 37 hypertensive patients without Hhcy. Transthoracic Doppler echocardiography was performed to assess the LV diastolic function of the patients.

Results

The plasma level of Hcy was directly related to LV diastolic echocardiographic parameters in patients with hypertension whereby the ratio E/e’ was higher (12.7 ± 2.64 vs. 8.98 ± 1.55, p < 0.01), e’/a’ was lower (0.59 ± 0.13 vs. 0.83 ± 0.20, p < 0.01), and the left atrial (LA) diameter was longer (43.4 ± 3.6 mm vs. 37.6 ± 5.0 mm, p < 0.01) in the Hhcy group than in the control group.

Conclusion

The LV diastolic function was significantly deteriorated in Chinese hypertensive patients with Hhcy and there were significant correlations between LV diastolic function indices and Hcy levels.

Zusammenfassung

Ziel

Ziel war es, die Auswirkungen des Homozysteins (Hcy) im Plasma auf die linksventrikuläre (LV) diastolische Funktion bei chinesischen Patienten mit essenzieller Hypertonie (HT) zu untersuchen.

Methoden

In die vorliegende Studie wurden 74 Patienten mit Hypertonie aufgenommen und je nach Plasmaspiegel für Hcy in 2 Gruppen unterteilt: eine Gruppe mit hohem Hcy-Spiegel (Hhcy; n = 37) und eine Kontrollgruppe mit normalem Hcy-Spiegel (n = 37). Die Studienteilnehmer bestanden aus 37 Hypertoniepatienten mit Hhcy und 37 Hypertoniepatienten ohne Hhcy. Zur Bestimmung der diastolischen LV-Funktion wurde bei den Patienten eine transthorakale Dopplerechokardiographie durchgeführt.

Ergebnisse

Der Hcy-Plasmaspiegel stand in direktem Zusammenhang mit diastolischen LV-Echokardiographieparametern bei Hypertoniepatienten. E/e‘ war höher (12,7 ± 2,64 vs. 8,98 ± 1,55; p < 0,01), e’/a‘ war niedriger (0,59 ± 0,13 vs. 0,83 ± 0,20; p < 0,01) und der linksatriale Durchmesser war in der Hhcy-Gruppe größer (43,4 ± 3,6 vs. 37,6 ± 5,0; p < 0,01) als in der Kontrollgruppe.

Schlussfolgerung

Die diastolische LV-Funktion war bei chinesischen Hypertoniepatienten mit Hhcy signifikant beeinträchtigt, dabei bestanden signifikante Korrelationen zwischen Indizes der diastolischen LV-Funktion und dem Hcy-Spiegel.

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Acknowledgments

We thank the technicians and staff at the Cardiology Department of Tongji Hospital for data collection and management. We also thank Professor Liu for his contribution to the statistical analysis.

Compliance with ethical guidelines

Conflict of interest. L. Ruhui, J. Jinfa, X. Jiahong, and M. Wenlin state that there are no conflicts of interest. All studies on humans described in the present manuscript were carried out with the approval of the responsible ethics committee and in accordance with national law and the Helsinki Declaration of 1975 (in its current, revised form). Informed consent was obtained from all patients included in studies.

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Authors and Affiliations

  1. Department of Cardiology, Tongji Hospital, Tongji University, No. 389 Xincun Road, 200065, Shanghai, China

    L. Ruhui, J. Jinfa, X. Jiahong & M. Wenlin

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  1. L. Ruhui
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Correspondence to M. Wenlin.

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Ruhui, L., Jinfa, J., Jiahong, X. et al. Influence of hyperhomocysteinemia on left ventricular diastolic function in Chinese patients with hypertension. Herz 40, 679–684 (2015). https://doi.org/10.1007/s00059-014-4098-x

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  • DOI: https://doi.org/10.1007/s00059-014-4098-x

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