Abstract.
Src tyrosine kinase is a critical signal transducer that modulates a wide variety of cellular functions. Misregulation of Src leads to cell transformation and cancer. Heterotrimeric guanine-nucleotide-binding proteins (G proteins) are another group of signaling molecules that transduce signals from cell-surface receptors to generate physiological responses. Recently, it was discovered that Gαs and Gαi could directly stimulate Src family tyrosine kinase activity. This novel regulation of Src tyrosine kinase by G proteins provides insights into the adenylyl cyclase-independent signaling mechanisms involved in ligand-induced receptor desensitization, internalization and other physiological processes.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received 17 August 2001; received after revision 22 October 2001; accepted 24 October 2001
Rights and permissions
About this article
Cite this article
Ma, YC., Huang, XY. Novel regulation and function of Src tyrosine kinase. CMLS, Cell. Mol. Life Sci. 59, 456–462 (2002). https://doi.org/10.1007/s00018-002-8438-2
Issue Date:
DOI: https://doi.org/10.1007/s00018-002-8438-2