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Endoplasmic reticulum stress: a vital process and potential therapeutic target in chronic obstructive pulmonary disease

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Abstract

Background

Chronic obstructive pulmonary disease (COPD), a chronic and progressive disease characterized by persistent respiratory symptoms and progressive airflow obstruction, has attracted extensive attention due to its high morbidity and mortality. Although the understanding of the pathogenesis of COPD has gradually increased because of increasing evidence, many questions regarding the mechanisms involved in COPD progression and its deleterious effects remain unanswered. Recent advances have shown the potential functions of endoplasmic reticulum (ER) stress in causing airway inflammation, emphasizing the vital role of unfolded protein response (UPR) pathways in the development of COPD.

Methods

A comprehensive search of major databases including PubMed, Scopus, and Web of Science was conducted to retrieve original research articles and reviews related to ER stress, UPR, and COPD.

Results

The common causes of COPD, namely cigarette smoke (CS) and air pollutants, induce ER stress through the generation of reactive oxygen species (ROS). UPR promotes mucus secretion and further plays a dual role in the cell apoptosis-autophagy axis in the development of COPD. Existing drug research has indicated the potential of UPR as a therapeutic target for COPD.

Conclusions

ER stress and UPR activation play significant roles in the etiology, pathogenesis, and treatment of COPD and discuss whether related genes can be used as biomarkers and therapeutic targets.

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Data availability

The data presented in this study are available on request from the authors.

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Funding

Our work is supported by the National Natural Science Foundation of China (82100079, 81901713).

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Author notes

  1. Hao Peng and Qing Zhou are contributed equally to this work.

Authors and Affiliations

  1. Department of Respiratory and Critical Care Medicine, NHC Key Laboratory of Respiratory Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, Wuhan, 430030, China

    Hao Peng, Qing Zhou, Jing Liu, Yi Wang & Lei Zhang

  2. Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jie Fang Avenue 1095, Wuhan, 430030, China

    Ketao Mu

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  1. Hao Peng
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  2. Qing Zhou
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  3. Jing Liu
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  4. Yi Wang
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  5. Ketao Mu
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  6. Lei Zhang
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Contributions

LZ and KM contributed to conceptualization; HP, JL, and YW were involved in writing—original draft preparation; LZ and QZ contributed to writing—review and editing; and KM was involved in supervision. All authors gave their approval for the final manuscript to be published.

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Correspondence to Ketao Mu or Lei Zhang.

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Peng, H., Zhou, Q., Liu, J. et al. Endoplasmic reticulum stress: a vital process and potential therapeutic target in chronic obstructive pulmonary disease. Inflamm. Res. 72, 1761–1772 (2023). https://doi.org/10.1007/s00011-023-01786-0

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  • DOI: https://doi.org/10.1007/s00011-023-01786-0

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