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Protoberberine aus Reissert-Verbindungen, 6. Mitt. [1]: Diastereoselektive Synthese und relative Konfiguration von 2-Benzoyl-1-cyano-1-(1-phenylalkyl)-1,2-dihydroisochinolinen

Protoberberins from Reissert Compounds VI [1]. Diastereoselective Synthesis and Relative Configuration of 2-Benzoyl-1-cyano-1-(1-phenylalkyl)-1,2-dihydroisoquinolines

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Summary.

 The alkylation of Reissert compounds 8 by sec-benzyl bromides 4, 7, and 10 diastereo-selectively affords the title compounds 11 and 12. X-Ray structure analysis confirms an opposite configuration of the chiral centers in 11 and 12. The benzyl bromides 4, 7, and 10 are prepared by standard procedures.

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Authors and Affiliations

  1. Institut für Pharmazie, Ludwig-Maximilians-Universität München, D-80333 München, Bundesrepublik Deutschland, DE

    Eberhard Reimann, Wolfgang Erdle, Claudia Weigl & Kurt Polborn

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  1. Eberhard Reimann
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  2. Wolfgang Erdle
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  3. Claudia Weigl
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  4. Kurt Polborn
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Received September 18, 1998. Accepted (revised) October 5, 1998

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Reimann, E., Erdle, W., Weigl, C. et al. Protoberberine aus Reissert-Verbindungen, 6. Mitt. [1]: Diastereoselektive Synthese und relative Konfiguration von 2-Benzoyl-1-cyano-1-(1-phenylalkyl)-1,2-dihydroisochinolinen. Monatshefte fuer Chemie 130, 313–326 (1999). https://doi.org/10.1007/PL00010212

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  • DOI: https://doi.org/10.1007/PL00010212

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