Abstract
A craniopharyngioma growing suprasellarly attacks the medio-basal region of the hypothalamus, interrupting the production of gonadotropin-releasing hormone. In the case of a 15-year-old girl who underwent partial extirpation of craniopharyngioma, favorable endocrine effects were obtained by pulsatile gonadotropin-releasing hormone treatment. Gonadotropin-releasing hormone administered in a dose of 20 μg every 90 min resulted in the achievement of a menstrual cycle and ovulation. Together with surgical treatment, hormonal substitution plays an important role in the treatment of endocrine symptoms.
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Koloszár, S., Bártfai, G. Pulsatile gonadotropin releasing hormone substitution following extirpation of suprasellar craniopharyngioma. J Endocrinol Invest 13, 753–756 (1990). https://doi.org/10.1007/BF03349616
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DOI: https://doi.org/10.1007/BF03349616