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Peripheral Precocious Puberty Caused by Human Chorionic Gonadotropin Producing Pineal Gland Tumor

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Abstract

Background

Pineal gland lesions usually present with central precocious puberty.

Case characteristics

A 3½-yr-old boy presented with precocious puberty. Clinically and biochemically, it was gonadotropin releasing hormone (GnRH) independent. Serum and CSF beta-hCG levels were increased. Thin section magnetic resonance imaging of brain revealed a pineal gland tumor.

Outcome

He received chemotherapy followed by radiotherapy and responded well.

Message

CSF β-hCG should be measured in all cases of peripheral precocity, and if CSF beta-hCG is elevated, thin section magnetic resonance imaging of brain should be considered.

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Author information

Authors and Affiliations

  1. Department of Endocrinology and Metabolism, AIIMS, New Delhi, 110 029, India

    S. K. Hammadur Rahaman, Deepak Khandelwal & Rajesh Khadgawat

  2. Department of Radiology, AIIMS, New Delhi, India

    Devasenathipathy Kandasamy

  3. Department of Medical Oncology, AIIMS, New Delhi, India

    Sameer Bakhshi

Authors
  1. S. K. Hammadur Rahaman
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  2. Deepak Khandelwal
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  3. Rajesh Khadgawat
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  4. Devasenathipathy Kandasamy
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  5. Sameer Bakhshi
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Corresponding author

Correspondence to S. K. Hammadur Rahaman.

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Rahaman, S.K.H., Khandelwal, D., Khadgawat, R. et al. Peripheral Precocious Puberty Caused by Human Chorionic Gonadotropin Producing Pineal Gland Tumor. Indian Pediatr 55, 254–256 (2018). https://doi.org/10.1007/s13312-018-1328-y

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  • DOI: https://doi.org/10.1007/s13312-018-1328-y

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