Resumen
Objetivos. El objetivo principal es posicionar los resultados obtenidos de un estudio económico de pegfilgrastim en las tablas clasificatorias de coste-efectividad de intervenciones sanitarias publicadas en España durante el período 1997–2006.
Métodos. Para elaborar las tablas clasificatorias se llevó a cabo una revisión bibliográfica en tres importantes bases de datos. El periodo de búsqueda fue desde 1997 hasta 2006. Con el empleo de los criterios de selección establecidos se localizaron 29 publicaciones con 42 observaciones de razones coste-efectividad incremental (RCEI) por AVAC ganados y 24 publicaciones con 42 observaciones de RCEI por AVG ganados. Los resultados se actualizaron a valores del año 2006.
Resultados. Excluyendo los valores extremos de las 42 observaciones para AVAC, se tienen 37 observaciones con una media de 12.295 € por AVAC ganado (IC del 95%: 7.534 €; 17.056 €). Considerando las 42 observaciones para AVG la media por RCEI fue de 22.339 € (IC del 95%: 8.703 €-35.975 €). Los resultados de la RCEI por AVAC ganado con pegfilgrastim fueron: (1) frente a filgrastim administrado durante 11 días: pegfilgrastim opción dominante y (2) frente a filgrastim administrado durante 6 días: 13.933 €. Los resultados de la RCEI por AVG con pegfilgrastim fueron: (1) frente a filgrastim administrado durante 11 días: pegfilgrastim opción dominante y (2) frente a filgrastim administrado durante 6 días: 13.180 €.
Conclusiones. Los resultados del análisis de evaluación económica de pegfilgrastim frente a filgrastim, medidos tanto en AVG como en AVAC, se encuentran dentro de los rangos de las razones de coste-efectividad incrementales obtenidas en la revisión de la literatura para España durante el período 1997–2006.
Abstract
Objectives. The main objective was to compare pegfilgratism cost-effectiveness results with those in the league tables developed for Spain based on economic evaluations published in Spain during 1997 to 2006.
Methods. A structured literature review was conducted in PubMed (National Library of Medicine), DOYMA Editions and the economic evaluation database developed by the Centre for Reviews and Disseminations (CRD-University of York). Time period covered in the review was from 1997 to 2007. Twenty nine abstracts and papers met the inclusion criteria with its corresponding 42 outputs reporting on ICER per QALY gained and 42 outputs reporting on ICER per LYG. Reported economic outcomes were converted to 2006 using consumer price index.
Results. From literature review, the mean ICER per QALY gained was estimated at 185,201 € (CI 95%: 615 €-369,786 €). While the mean ICER per LYG was estimated at 22,339 € (CI 95%: 8,703 €-35,975 €). The economic model estimated pegfilgrastim to be the dominant option over filgrastim (administered for 11 days) regardless whether the ICER per QALY or per LYG was used as the metric. While the ICER per QALY gained of pegfilgrastim as compared to filgrastim (administered for 6 days) was 13,933€ (13,180€ per LYG).
Conclusions. The results of the economic analysis of pegfilgratim frente a Filgrastim measured in LYG and QALYs, are within the range of ICER obtained in the literature review conducted for Spain during the period 1997–2006.
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Darbà, J., Restovic, G. & Arocho, R. Posicionamiento de pegfilgrastim en las tablas clasificatorias de España según coste por años de vida ajustados por calidad (AVAC) y coste por años de vida ganados (AVG). Pharmacoecon. Span. Res. Artic. 5, 94–107 (2008). https://doi.org/10.1007/BF03320846
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DOI: https://doi.org/10.1007/BF03320846