Skip to main content
SpringerLink
Log in

Ulipristal acetate: a guide to its use in uterine fibroids

  • Adis Drug Clinical Q&A
  • Published:
Drugs & Therapy Perspectives Aims and scope Submit manuscript

Abstract

Oral ulipristal acetate (Esmya™), a selective progesterone-receptor modulator, is an effective and well tolerated option for the pre-operative treatment of moderate to severe symptoms of uterine fibroids in adult women of reproductive age. It is associated with rapid control of excessive uterine bleeding and sustained reductions in uterine fibroid volume.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Table I
Table II

Similar content being viewed by others

References

  1. Practice Committee of American Society for Reproductive Medicine in collaboration with Society of Reproductive Surgeons. Myomas and reproductive function. Fertil Steril 2008; 90 (5 Suppl.): S125–30

    Article  Google Scholar 

  2. McCarthy-Keith DM, Armstrong AY. Innovations in uterine fibroid therapy. Therapy 2011; 8 (2): 189–200

    Article  CAS  Google Scholar 

  3. Duhan N. Current and emerging treatments for uterine myoma: an update. Int J Womens Health 2011; 3 (1): 231–42

    Article  PubMed  Google Scholar 

  4. Stewart EA. Uterine fibroids and evidence-based medicine: not an oxymoron. N Engl J Med 2012 Feb 2; 366 (5): 471–3

    Article  PubMed  CAS  Google Scholar 

  5. Esmya 5 mg tablets (ulipristal acetate): summary of product characteristics. London: European Medicines Agency, 2012 Mar 15

  6. Croxtall JD. Ulipristal acetate in uterine fibroids. Drugs 2012; 72 (8): 1075–85

    Article  PubMed  CAS  Google Scholar 

  7. Chabbert-Buffet N, Pintiaux-Kairis A, Bouchard P. Effects of the progesterone receptor modulator VA2914 in a continuous low dose on the hypothalamic-pituitary-ovarian axis and endometrium in normal women: a prospective, randomized, placebo-controlled trial. J Clin Endocrinol Metab 2007 Sep; 92 (9): 3582–9

    Article  PubMed  CAS  Google Scholar 

  8. Yoshida S, Ohara N, Xu Q, et al. Cell-type specific actions of progesterone receptor modulators in the regulation of uterine leiomyoma growth. Semin Reprod Med 2010 May; 28 (3): 260–73

    Article  PubMed  CAS  Google Scholar 

  9. Donnez J, Tatarchuk TF, Bouchard P, et al. Ulipristal acetate versus placebo for fibroid treatment before surgery. N Engl J Med 2012 Feb 2; 366 (5): 409–20

    Article  PubMed  CAS  Google Scholar 

  10. Donnez J, Tomaszewski J, Vazquez F, et al. Ulipristal acetate versus leuprolide acetate for uterine fibroids. N Engl J Med 2012 Feb 2; 366 (5): 421–32

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgements and Disclosures

This article was adapted from Drugs 2012; 72 (8): 1075-85[6] and reviewed by T. Al-Shawaf, Barts and The London Centre of Reproductive Medicine, St Bartholomew’s Hospital, London, UK; L. Bahamondes, Department of Obstetrics and Gynaecology, University of Campinas, Campinas, Brazil.

The preparation of these articles was not supported by any external funding. During the peer review process, the manufacturer of the agent under review was offered an opportunity to comment on the articles. Changes resulting from comments received were made by the authors on the basis of scientific and editorial merit.

Author information

Authors and Affiliations

  1. Adis, 41 Centorian Drive, Private Bag 65901, Mairangi Bay, North Shore 0754, Auckland, New Zealand

    Katherine A. Lyseng-Williamson & Jamie D. Croxtall

Authors
  1. Katherine A. Lyseng-Williamson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jamie D. Croxtall
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Katherine A. Lyseng-Williamson.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lyseng-Williamson, K.A., Croxtall, J.D. Ulipristal acetate: a guide to its use in uterine fibroids. Drugs Ther Perspect 28, 1–4 (2012). https://doi.org/10.1007/BF03262118

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03262118

Keywords

Search

Navigation