Summary
The present study evaluates the effect of oral administration of papaverine at differential dosing regimens (100 mg/kg bw and 200mg/kg bw) on the hepatic and pulmonary glutathione S-transferase (GST) activity and glutathione content (GSH) in male Wistar rats. Papaverine treatment caused a pronounced increase in GST activity and GSH content at the higher dosing level in the rat liver and lung. We conclude that papaverine, can possibly act as a chemopreventive agent against chemical carcinogenesis.
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Aneja, R., Sharma, A., Talwar, A. et al. Papaverine, an opium alkaloid influences hepatic and pulmonary glutathione s-transferase activity and glutathione content in rats. European Journal of Drug Metabolism and Pharmacokinetics 29, 107–110 (2004). https://doi.org/10.1007/BF03190584
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DOI: https://doi.org/10.1007/BF03190584