Summary
The absorption and elimination of succinimide have been investigated in healthy volunteers after the oral administration of a single dose of 10 g of succinimide per person. Succinimide was spectrophotometrically determined in serum by treating succinimide with hydroxylamine at pH 8.3 and measuring the absorbance of the resultant N-hydroxysuccinimide at 260 nm. Comparison of the pharmacokinetic parameters with those previously obtained in rats showed that, in man, succinimide is absorbed more quickly and eliminated more slowly, whereas the distribution coefficients of succinimide in man and in rats are similar.
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References
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Schulte, K.E., Henke, G. Pharmacokinetics of orally administered succinimide in man. European Journal of Drug Metabolism and Pharmacokinetics 3, 161–163 (1978). https://doi.org/10.1007/BF03189501
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DOI: https://doi.org/10.1007/BF03189501