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Soluble adhesion molecules in inflammatory bowel disease

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Abstract

Background

Soluble adhesion molecules are elevated in a number of inflammatory conditions.

Aims

To investigate the correlation of soluble intercellular adhesion molecule-1 (sICAM-1) and sE-selectin with the activity of inflammatory bowel disease (IBD).

Methods

sICAM-1 and sE-selectin were measured by an enzyme-linked immunosorbent assay (ELISA) in 53 patients with ulcerative colitis (UC) and 38 patients with Crohn’s disease (CD).

Results

Patients with active UC and CD had significantly higher sICAM-1 than patients with inactive disease and controls. Paients with pancolitis had significantly higher levels than patients with distal colitis. There was a significant difference in sE-selectin levels between paients with acive CD and control sICAM-1. sE-seiectin did not correlate with the Harvey Bradshaw index (HBI). C-reactive protein (CRP) and microalbuminuria were better markers than sICAM-1 or sE-selectin which correlated with serum tumour necrosis factor (TNF)-α.

Conclusion

sICAM-1 and sE-selecin are elevated in the serum of paients with IBD but CRP and microalbuminuria reflect clinical disease activity more accurately. This study does not support the routine use of soluble adhesion molecules as disease activity markers in IBD.

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Authors and Affiliations

  1. Departments of Clinical Medicine and Gastroenterology, Trinity College and St James’s Hospital, Dublin, Ireland

    M. G. Goggins, J. Goh, M. A. O’Connell, D. G. Weir, D. Kelleher & N. Mahmud

Authors
  1. M. G. Goggins
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  2. J. Goh
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  3. M. A. O’Connell
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  4. D. G. Weir
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  5. D. Kelleher
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  6. N. Mahmud
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Goggins, M.G., Goh, J., O’Connell, M.A. et al. Soluble adhesion molecules in inflammatory bowel disease. Ir J Med Sci 170, 107–111 (2001). https://doi.org/10.1007/BF03168821

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