Abstract
Cell-mediated immune responses to various nervous antigens were examined in 12 cases of Guillain-Barré syndrome (GBS), 24 cases of noninflammatory peripheral neuropathy (NIPN), and 18 cases of degenerative disorders of central nervous system (CNSDD), using the lymphocyte-transformation technique. Cellular hypersensitivity to bovine P2 protein (P2) and a synthetic peptide, SP66-78, corresponding to the residues 66–78 of P2, was detected in about two-thirds of GBS cases, especially in the active or improving stages, but not in NIPN and CNSDD. The lymphocytes sensitized to these nervous antigens might play an important role in the pathogenesis of GBS.
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Abramsky, O., Webb, C., Teitelbaum, D., and Arnon, R. (1975) Cell-mediated immunity to neural antigens in idiopathic polyneuritis and myeloradiculitis. Clinical-immunologic classification of several autoimmune demyelinating disorders.Neurology 25, 1154–1159.
Abramsky, O., Korn-Lubetsky, I., and Teitelbaum, D. (1980) Association with autoimmune diseases and cellular immune response to the neuritogenic protein in Guillain-Barré syndrome.Trans. Am. Neurol. Ass. 105, 350–354.
Deibler, G. E., Driscoll, B. F., and Kies, M. W. (1978) Immunochemical and biochemical studies demonstrating the identity of a bovine spinal cord protein (SCP) and a basic protein of bovine peripheral nerve myelin (BF).J. Neurochem. 30, 401–412.
Hughes, R. A. C., Gray, I. A., Gregson, N. A., Kadlubowski, M., Kennedy, M., Leibowitz, S., and Thompson, H. (1984) Immune response to myelin antigens in Guillain-Barré syndrome.J. Neuroimmunol. 6, 303–312.
Iqbal, A., Oger, J. J.-F., and Arnason, B. G. W. (1981) Cell-mediated immunity in idiopathic polyneuritis.Ann. Neurol. 9 (Suppl), 65–69.
Kadlubowski, M. and Hughes, R. A. C. (1979) Identification of the neuritogen for experimental allergic neuritis.Nature 277, 140–141.
Kitamura, K., Yamanaka, T., and Uyemura, K. (1975) On basic proteins in bovine peripheral nerve myelin.Biochim. Biophys. Acta 379, 582–591.
Martenson, R. E. (1983) A general model of the P2 protein of peripheral nervous system myelin based on secondary structure predictions, tertiary folding principles, and experimental observations.J. Neurochem. 40, 951.
Sheremata, W., Colby, S., Karnhanis, Y., and Eylar, E. H. (1975) Cellular hypersensitivity to basic myelin (P2) protein in the Guillain-Barré syndrome.Can. J. Neurol. Sci. 2, 87–90.
Suzuki, M., Kitamura, K., Uyemura, K., Ogawa, Y., Ishihara, Y., and Matsuyama, H. (1980) Neuritogenic activity of peripheral nerve myelin proteins in Lewis rats.Neurosci. Lett. 19, 353–358.
Suzuki, M., Kitamura, K., Uyemura, K., Ogawa, Y., Nozaki, S., and Muramatsu, I. (1984) Synthesis and neuritogenic activity of the peptides related to P2 protein, inExperimental allergic encephalomyelitis: A useful model for multiple sclerosis, pp. 487–492. Alan R. Liss, New York, NY.
Uyemura, K., Suzuki, M., Kitamura, K., Horie, K., Ogawa, Y., Matsuyama, H., Nozaki, S., and Muramatsu, I. (1982) Neuritogenic determinant of bovine P2 protein in peripheral nerve myelin.J. Neurochem. 39, 895–898.
Weise, M. J., Hsieh, D., Hoffman, P. M., Powers, J. M., and Brostoff, S. W. (1980) Bovine peripheral nervous system myelin P2 protein: Chemical and immunological characterization of the cyanogen bromide peptides.J. Neurochem. 35, 393–399.
Zweiman, B., Rostami, A., Lisak, R. P., Moskovitz, A. R., and Pleasure, D. E. (1983) Immune reactions to P2 protein in human inflammatory demyelinative neuropathies.Neurology 33, 234–237.
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Ohno, R., Hamaguchi, K., Nomura, K. et al. Cellular hypersensitivity to nervous antigens in Guillain-Barré syndrome. Neurochemical Pathology 4, 119–126 (1986). https://doi.org/10.1007/BF03160190
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DOI: https://doi.org/10.1007/BF03160190