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Prospects for redox-based therapy in neurodegenerative diseases

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Abstract

Accumulating evidence supports a primary role for perturbations in redox metabolism in the pathogenesis of many neurodegenerative diseases. This evidence derives mainly from molecular genetic analysis, direct observation from post-mortem human brain, and biochemical, pathologic, and therapeutic studies in transgenic and other animal models of neurodegeneration. We review here the evidence for redox-mediated pathogenesis in neurodegenerative diseases. The emerging class of redox-based therapeutic agents is then discussed. Drugs of this class are distinguished by their proximate effect, which is oxidative and not phosphorylative.

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  1. Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 525 East 68th Street, New York, NY, 10021, USA

    Avi L. Friedlich & M. Flint Beal

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Friedlich, A.L., Beal, M.F. Prospects for redox-based therapy in neurodegenerative diseases. neurotox res 2, 229–237 (2000). https://doi.org/10.1007/BF03033796

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