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Oxidative stress in neurodegeneration: targeting mitochondria as a therapeutic aid

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Metal Ions in Neurological Systems

Abstract

Increasing evidence links oxidative stress caused by radical overproduction and/or impaired antioxidant defenses with the onset of neurodegenerative diseases. Mitochondria have been shown to play a major role due to their specialized ability in producing free radicals joined with their sensitivity to the toxic effects of free radicals. The present article provides a short review of the sources of free radicals, the sites of their generation, the mitochondrial detoxifying systems and the consequences of oxidative stress. As main examples, the roles played by mitochondria in Alzheimer’s and Parkinson’s diseases are briefly considered. Finally, drugs targeting antioxidant moieties to mitochondria are shortly described and summarized

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Acknowledgments

We acknowledge Prof. Henryk Kozlowski for his continuous support and suggestions. We also want to apologize for all the reports we have not mentioned. The number of records found by any motor of research is incredibly huge and it is practically impossible to mention all the work done, especially in the last 5–10 years. Among the literature reports, many review articles can be found [2, 149–163].

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Authors and Affiliations

  1. Department of Chemistry, University of Siena, Siena, Italy

    Elena Gaggelli

  2. Department of Chemistry, University of Siena, Via Aldo Moro 2, Siena, 53100, Italy

    Gianni Valensin

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  1. Elena Gaggelli
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  2. Gianni Valensin
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Correspondence to Gianni Valensin .

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  1. , Institute of Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9, Vienna, 1060, Austria

    Wolfgang Linert

  2. Faculty of Chemistry, University of Wroclaw, ul. Fryderyka Joliot Curie 14, Wroclaw, 50-383, Poland

    Henryk Kozlowski

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Gaggelli, E., Valensin, G. (2012). Oxidative stress in neurodegeneration: targeting mitochondria as a therapeutic aid. In: Linert, W., Kozlowski, H. (eds) Metal Ions in Neurological Systems. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1001-0_12

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