Summary
The effect of beta-adrenergic blockade produced by propranolol (0,25 mg/kg) on myocardial haemodynamics and metabolism was investigated in eight closedchest dogs lightly anaesthetized with halothane (0.69% expired). A significant decrease in cardiac output and left ventricular stroke work was seen, with increases in left ventricular end diastolic pressures, mean aortic pressure, and peripheral vascular resistance. There was no change in heart rate, right atrial pressure, or the rate of rise of left ventricular pressure (dp/dt). Myocardial blood flow, oxygen uptake, and excess lactate were likewise unchanged. There was no significant difference between the control and beta-blocked animals in the arterial levels or in regard to the myocardial uptake of glucose, non-esterified fatty acids, lactate, or pyruvate. It appeared that the myocardial depression produced by beta adrenergic blockade in these animals was offset by the increased peripheral vascular resistance and mean aortic blood pressure. It is suggested that were such compensation not possible, the effect of beta-adrenergic blockade in light halothane anaesthesia might be more deleterious.
Résumé
Sur huit chiens à thorax fermé, légèrement anesthésiés au fluothane (0.69% à ľexpiration), on a cherché ľeffet ďun blocage adrénergique bêta sur ľhemo-dynamique et le métabolisme myocardique. On a observé une diminution importante du débit cardiaque et du travail de la systole ventriculaire gauche, avec une augmentation des pressions ventriculaire gauche et diastolique, de la pression aortique moyenne et de la résistance vasculaire périphérique. Il n’y a pas eu de changement du rythme cardiaque, de la pression auriculaire droite ou du taux ďéléVation de la pression ventriculaire gauche (dp/dt). Le courant sanguin du myocarde, la consommation ďoxygène et le lactate sont demeurés inchanges. Il n’y a pas eu de différence importante entre les animaux de contrôle et les animaux soumis au blocage bêta quant au niveau artériel ou à la consommation myocardique du glucose, des acides gras, du lactate ou du pyruvate. Il a semblé que la depression myocardique produite chez ces animaux par le blocage adrénergique beta était causée par la résistance vasculaire périphérique augmentée et par ľélévation de la pression sanguine aortique moyenne. On suppose que si une telle compensation n’était pas possible, ľeffet du blocage adrénergique bêta sous anesthésie légère au fluothane pourrait être plus nocive.
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Merin, R.G., Tonnesen, A.S. The effect of beta-adrenergic blockade on myocardial haemodynamics and metabolism during light halothane anaesthesia. Can. Anaes. Soc. J. 16, 336–344 (1969). https://doi.org/10.1007/BF03004463
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DOI: https://doi.org/10.1007/BF03004463