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The effect of insulin on motility of the stomach following bilateral vagotomy

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The American Journal of Digestive Diseases

Conclusions

These experiments show the following effects of insulin on the motility of the stomach.

1. In the normal animal the administration of insulin accelerates the motility of the stomach.

2. In the bilaterally vagotomized animal there is a greater inhibition of gastric motility, exceeding that observed after bilateral vagotomy without insulin.

3. In addition to the gastric motility inhibition, insulin further diminishes the gastric tone and causes an increased gastric retention and greater dilatation of the stomach than that observed following bilateral vagotomy without insulin.

4. It would appear that the effects of insulin are mediated through the vagus nerves.

Finally it is suggested that on the basis of the data presented, a roentgen insulin test for the determination of vagotomy could be developed.

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References

  1. Quigley, P., Johnson, V. and Solomon, E. I.: Am. J. Physiology, 90:89, 1929.

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Authors and Affiliations

  1. Baltimore, Maryland

    Maurice Feldman M.D. & Samuel Morrison M.D.

Authors
  1. Maurice Feldman M.D.
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  2. Samuel Morrison M.D.
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Additional information

From the University of Maryland, School of Medicine. Department of Gastroenterology.

The expense of carrying out these experiments was defrayed in part by the Dr. Julius Friedenwald Fund.

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Feldman, M., Morrison, S. The effect of insulin on motility of the stomach following bilateral vagotomy. Jour. D. D. 15, 175 (1948). https://doi.org/10.1007/BF03001804

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  • DOI: https://doi.org/10.1007/BF03001804

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