Summary
1. In two series of rats, 40 per cent (Series 1) and 80 per cent (Series 2) of the jejunum and ileum were removed, respectively.
2. After recovery from the operation, rats in Series 1 remained normal over a nine month period of observation. Rats in Series 2 developed skin lesions after five months, began losing weight, and were sacrificed or died because of their declining condition within 8 1/2 months after operation.
3. All rats developed a mild normochromic to hypochromic anemia following enterectomy while two rats in Series 2 developed rather marked hypochromic anemias. The blood picture usually recovered spontaneously within 6 to 10 weeks after operation.
4. Varying degrees of hypertrophy occurred in the remaining small intestines in all rats in Series 2. It occurred in only half the rats in Series 1 and was less marked.
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From the Departments of Medicine and Chemistry, Northwestern University Medical School.
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Alt, H.L. Extensive resection of the small intestine in the rat with special reference to anemia. American Journal of Digestive Diseases and Nutrition 3, 169–173 (1936). https://doi.org/10.1007/BF02999104
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DOI: https://doi.org/10.1007/BF02999104