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Malignant Tumors

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Video Capsule Endoscopy

Abstract

Tumors of the small bowel account for 5 % of all gastrointestinal tract tumors and 2 % of the cancers (Table 34.1). Before the advent of capsule endoscopy, however, the methods for examining the small bowel were inadequate, so the accuracy of these figures may be questioned. The diagnosis of small-bowel tumors is often delayed, contributing to the poor prognosis in patients with malignant tumors. In 1995, 4,600 new cases of cancer in the small intestine were reported, with 1,120 deaths [1]. Tumors are typically missed by most radiographic tests, and thus tumors of the small bowel generally carried a dismal prognosis before small intestinal endoscopy. In 1980, Herbsman et al. [2] reported that survival of more than 6 months for adenocarcinoma of the small bowel was rare. More recently, with earlier detection due to small-bowel endoscopic techniques, the overall 5-year survival is reported to be 57 %, and the median survival is 52 months [3]. The prognosis for adenocarcinoma generally is less favorable than for other small-bowel malignancies [4], depending on tumor stage [5]. In a review of 1,260 cases, 305 were located in the ileum, 25 % in the duodenum, and 15 % in the jejunum [6].

The work was first published in 2006 by Springer Medizin Verlag Heidelberg with the following title: Atlas of Video Capsule Endoscopy.

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References

  1. Conn M. Tumors of the small intestine. In: DiMarino A, Benjamin S, editors. Gastrointestinal disease: an endoscopic approach. Malden: Blackwell Science; 1997. p. 551–66.

    Google Scholar 

  2. Herbsman H, Wetstein L, Rosen Y, et al. Tumors of the small intestine. Curr Probl Surg. 1980;17:121.

    Article  CAS  PubMed  Google Scholar 

  3. North JH, Pack MS. Malignant tumors of the small intestine: a review of 144 cases. Am Surg. 2000;66:46–51.

    CAS  PubMed  Google Scholar 

  4. Qubaiah O, Devesa SS, Platz CE, et al. Small intestinal cancer: a population-based study of incidence and survival patterns in the United States, 1992 to 2006. Cancer Epidemiol Biomarkers Prev. 2010;19:1908–18.

    Article  PubMed Central  PubMed  Google Scholar 

  5. Wu TJ, Yeh CN, Chao TC, et al. Prognostic factors of primary small bowel adenocarcinoma: univariate and multivariate analysis. World J Surg. 2006;30:391–8.

    Article  PubMed  Google Scholar 

  6. Hatzaras I, Palesty A, Abir F, et al. Small bowel tumors, epidemiologic and clinical characteristics of 1260 cases from the Connecticut Tumor Registry. Arch Surg. 2007;142:229–35.

    Article  PubMed  Google Scholar 

  7. Rossini FP, Risio M, Pennazio M. Small bowel tumors and polyposis syndromes. Gastrointest Endosc Clin N Am. 1999;9:93–114.

    CAS  PubMed  Google Scholar 

  8. Barakat M. Endoscopic features of primary small bowel lymphoma: a proposed endoscopic classification. Gut. 1982;23:36–41.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  9. Halphen M, Najjar T, Jaafoura H, et al. Diagnostic value of upper intestinal fiber endoscopy in primary small intestinal lymphoma. Cancer. 1986;58:2140–5.

    Article  CAS  PubMed  Google Scholar 

  10. Mascarenhas-Saraiva MN, da Silva Araujo Lopes LM. Small-bowel tumors diagnosed by wireless capsule endoscopy: report of five cases. Endoscopy. 2003;35:865–8.

    Article  PubMed  Google Scholar 

  11. Cobrin GM, Pittman RH, Lewis BS. Diagnosing small bowel tumors with capsule endoscopy. Gastroenterology. 2004;126 Suppl 2:A194–5.

    Google Scholar 

  12. Bailey AA, Debinski HS, Appleyard MN, et al. Diagnosis and outcome of small bowel tumors found by capsule endoscopy: a three-center Australian experience. Am J Gastroenterol. 2006;101: 2237–43.

    Article  PubMed  Google Scholar 

  13. Rondonotti E, Pennazio M, Toth E, et al. Small-bowel neoplasms in patients undergoing video capsule endoscopy: a multicenter European study. Endoscopy. 2008;40:488–95.

    Article  CAS  PubMed  Google Scholar 

  14. Achour J, Serraj I, Amrani L, Amrani N. Small bowel tumors: what is the contribution of video capsule endoscopy? Clin Res Hepatol Gastroenterol. 2012;36:222–6.

    Article  PubMed  Google Scholar 

  15. Madisch A, Schimming W, Kinzel F, et al. Locally advanced small-bowel adenocarcinoma missed primarily by capsule endoscopy but diagnosed by push enteroscopy. Endoscopy. 2003;35:861–4.

    Article  CAS  PubMed  Google Scholar 

  16. Knop FK, Hansen MB, Meisner S. Small-bowel hemangiosarcoma and capsule endoscopy. Endoscopy. 2003;35:637.

    Article  CAS  PubMed  Google Scholar 

  17. Ross A, Mehdizadeh S, Tokar J, et al. Double balloon enteroscopy detects small bowel mass lesions missed by capsule endoscopy. Dig Dis Sci. 2008;53:2140–3.

    Article  PubMed  Google Scholar 

  18. Hara AK, Leighton JA, Sharma VK, Fleischer DE. Small bowel: preliminary comparison of capsule endoscopy with barium study and CT. Radiology. 2004;230:260–5.

    Article  PubMed  Google Scholar 

  19. Brucher BL, Roder JD, Fink U, et al. Prognostic factors in resected primary small bowel tumors. Dig Surg. 1998;15:42–51.

    Article  CAS  PubMed  Google Scholar 

  20. Abrahams NA, Halverson A, Fazio VW, et al. Adenocarcinoma of the small bowel: a study of 37 cases with emphasis on histologic prognostic factors. Dis Colon Rectum. 2002;45:1496–502.

    Article  PubMed  Google Scholar 

  21. Klöppel G, Perren A, Heitz PU. The gastroenteropancreatic neuroendocrine cell system and its tumors: the WHO classification. Ann N Y Acad Sci. 2004;1014:13–27.

    Article  PubMed  Google Scholar 

  22. Klimstra DS, Modlin IR, Adsay NV, et al. Pathology reporting of neuroendocrine tumors: application of the Delphic consensus process to the development of a minimum pathology data set. Am J Surg Pathol. 2010;34:300–13.

    Article  PubMed  Google Scholar 

  23. Modlin IM, Lye KD, Kidd M. A 5-decade analysis of 13,715 carcinoid tumors. Cancer. 2003;97:934–59.

    Article  PubMed  Google Scholar 

  24. Hemminki K, Li X. Incidence trends and risk factors of carcinoid tumors: a nationwide epidemiologic study from Sweden. Cancer. 2001;92:2204–10.

    Article  CAS  PubMed  Google Scholar 

  25. Cross AJ, Leitzmann MF, Subar AF, et al. A prospective study of meat and fat intake in relation to small intestinal cancer. Cancer Res. 2008;68:9274–9.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  26. Horton KM, Kamel I, Hofmann L, Fishman EK. Carcinoid tumors of the small bowel: a multitechnique imaging approach. AJR Am J Roentgenol. 2004;182:559–67.

    Article  PubMed  Google Scholar 

  27. Johanssen S, Boivin M, Lochs H, Voderholzer W. The yield of wireless capsule endoscopy in the detection of neuroendocrine tumors in comparison with CT enteroclysis. Gastrointest Endosc. 2006;63:660–5.

    Article  PubMed  Google Scholar 

  28. van Tuyl SA, van Noorden JT, Timmer R, et al. Detection of small-bowel neuroendocrine tumors by video capsule endoscopy. Gastrointest Endosc. 2006;64:66–72.

    Article  PubMed  Google Scholar 

  29. Oberg K, Kvols L, Caplin M, et al. Consensus report on the use of somatostatin analogs for the management of neuroendocrine tumors of the gastroenteropancreatic system. Ann Oncol. 2004;15:966–73.

    Article  CAS  PubMed  Google Scholar 

  30. Buscombe JR, Caplin ME, Hilson AJ. Long-term efficacy of high-activity 111 in-pentetreotide therapy in patients with disseminated neuroendocrine tumors. J Nucl Med. 2003;44:1–6.

    CAS  PubMed  Google Scholar 

  31. Logrono R, Jones DV, Faruqi S, Bhutani MS. Recent advances in cell biology, diagnosis, and therapy of gastrointestinal stromal tumor (GIST). Cancer Biol Ther. 2004;3:251–8.

    Article  PubMed  Google Scholar 

  32. Burkill GJ, Badran M, Al Muderis O, et al. Malignant gastrointestinal stromal tumor: distribution, imaging features, and pattern of metastatic spread. Radiology. 2003;226:527–32.

    Article  PubMed  Google Scholar 

  33. Tazawa K, Tsukada K, Makuuchi H, Tsutsumi Y. An immunohistochemical and clinicopathological study of gastrointestinal stromal tumors. Pathol Int. 1999;49:786–98.

    Article  CAS  PubMed  Google Scholar 

  34. Nakatani M, Fujiwara Y, Nagami Y, et al. The usefulness of double-balloon enteroscopy in gastrointestinal stromal tumors of the small bowel with obscure gastrointestinal bleeding. Intern Med. 2012;51:2675–82.

    Article  PubMed  Google Scholar 

  35. Neville CR, Peddada AV, Smith D, et al. Massive gastrointestinal hemorrhage from AIDS-related Kaposi’s sarcoma confined to the small bowel managed with radiation. Med Pediatr Oncol. 1996;26:135–8.

    Article  CAS  PubMed  Google Scholar 

  36. Viazis N, Vlachogiannakos J, Georgiadis D, et al. Classic Kaposi’s sarcoma and involvement of the small intestine as shown by capsule endoscopy. Endoscopy. 2008;40 Suppl 2:E209.

    Article  PubMed  Google Scholar 

  37. Feller AC, Diebold J. Histopathology of nodal and extranodal non-Hodgkin’s lymphomas. 3rd ed. Berlin/Heidelberg/New York: Springer; 2004.

    Book  Google Scholar 

  38. Chaaya A, Heller SJ. Introduction to small bowel tumors. Tech Gastrointest Endosc. 2012;14:88–93.

    Article  Google Scholar 

  39. Nakamura M, Ohmiya N, Hirooka Y, et al. Endoscopic diagnosis of follicular lymphoma with small-bowel involvement using video capsule endoscopy and double-balloon endoscopy: a case series. Endoscopy. 2013;45:67–70.

    Article  CAS  PubMed  Google Scholar 

  40. Flieger D, Keller R, May A, et al. Capsule endoscopy in gastrointestinal lymphomas. Endoscopy. 2005;37:1174–80.

    Article  CAS  PubMed  Google Scholar 

  41. Hartmann D, Schilling D, Rebel M, et al. Diagnosis of a high-grade B-cell lymphoma of the small bowel by means of wireless capsule endoscopy. Z Gastroenterol. 2003;41:171–4.

    Article  CAS  PubMed  Google Scholar 

  42. Ersoy O, Akin E, Demirezer A, et al. Capsule endoscopic findings in immunoproliferative small intestinal disease. Endoscopy. 2012;44:E61–2.

    Article  PubMed  Google Scholar 

  43. Fischbach W. Gastrointestinal lymphomas. [Article in German]. Z Gastroenterol. 2004;42:1067–72.

    Article  CAS  PubMed  Google Scholar 

  44. Prakoso E, Selby WS. Polypoid and non-pigmented small-bowel melanoma in capsule endoscopy is common. Endoscopy. 2010;42:979.

    Article  CAS  PubMed  Google Scholar 

  45. Albert JG, Fechner M, Fiedler E, et al. Algorithm for detection of small-bowel metastasis in malignant melanoma of the skin. Endoscopy. 2011;43:490–8.

    Article  CAS  PubMed  Google Scholar 

  46. Khosrowshahi E, Horvath W. Primary malignant melanoma of the small intestine – a case report. Rontgenpraxis. 2002;54:220–3.

    PubMed  Google Scholar 

  47. Washington K, McDonagh D. Secondary tumors of the gastrointestinal tract: surgical pathologic findings and comparison with autopsy survey. Mod Pathol. 1995;8:427–33.

    CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Mount Sinai Hospital, New York, NY, USA

    Blair S. Lewis

  2. Department of Internal Medicine, Bethesda Krankenhaus Bergedorf, Hamburg, Germany

    Martin Keuchel

  3. Department of Gastroenterology, Allgemeines Krankenhaus Celle, Celle, Germany

    Felix Wiedbrauck

  4. Department for Pathology, Asklepios Klinik Altona, Hamburg, Germany

    Jörg Caselitz

  5. Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan

    Yasuo Kakugawa & Yutaka Saito

Authors
  1. Blair S. Lewis
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  2. Martin Keuchel
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  3. Felix Wiedbrauck
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  4. Jörg Caselitz
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  5. Yasuo Kakugawa
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  6. Yutaka Saito
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Corresponding author

Correspondence to Blair S. Lewis .

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Editors and Affiliations

  1. Department of Internal Medicine, Bethesda Krankenhaus Bergedorf, Academic Teaching Hospital of the University of Hamburg, Hamburg, Germany

    Martin Keuchel

  2. 1st Medical Department, Asklepios Klinik Altona, Academic Teaching Hospital of the University of Hamburg, Hamburg, Germany

    Friedrich Hagenmüller

  3. Dept. Internal Medicine, Division of Gastroenterology and Hepatology, The Jikei University School of Medicine, Tokyo, Japan

    Hisao Tajiri

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© 2014 Springer-Verlag Berlin Heidelberg

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Lewis, B.S., Keuchel, M., Wiedbrauck, F., Caselitz, J., Kakugawa, Y., Saito, Y. (2014). Malignant Tumors. In: Keuchel, M., Hagenmüller, F., Tajiri, H. (eds) Video Capsule Endoscopy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-44062-9_34

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  • DOI: https://doi.org/10.1007/978-3-662-44062-9_34

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-44061-2

  • Online ISBN: 978-3-662-44062-9

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