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What is the hereditary non-polyposis colorectal cancer syndrome?

Sindrome del cáncer de colon hereditario no polipósico (CCHNP)

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Abstract

Hereditary non-polyposis colorectal cancer syndrome may account for up to 4% of the total colorectal cancer burden. The earliest reference to inheritance in colorectal cancer was a century ago and intensive research since then has resulted in the present knowledge of its molecular basis, clinical identification, and genetic diagnosis. The aim of this review is to highlight the historical evolution, genetic, molecular, and biological features that underlie the clinical management of both affected patients and at-risk family members.

Resumen

El cáncer de colon hereditario no polipósico (CCHNP) es un síndrome que representa aproximadamente el 4% del total de cáncer colorrectal. La primera referencia al carácter hereditario del cáncer colorrectal fue a finales del siglo pasado, y el conocimiento actual de su base molecular, identificación clínica y diagnóstico genético es fruto de las investigaciones que se han llevado a cabo en este campo desde entonces. El objetivo de esta revisión es resaltar su evolución histórica, sus características genéticas, moleculares y biológicas que condicionan el manejo clínico de estos pacientes y de los familiares a riesgo.

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Authors and Affiliations

  1. Servei d’Oncologia Mèdica, Hospital de la Santa Creu i Sant Pau, Sant Antoni M.a Claret, 167, 08025, Barcelona

    Judith Balmaña, Carlos Pericay, Juan José López López & Eugenio Marcuello

  2. Servei d’Oncologia Mèdica, Hospital Sant Joan de Reus, Spain

    Joan Brunet

  3. L’Hospitalet de Llobregat, Institut Català d’Oncologia i, Barcelona

    Gabriel Capellà

  4. L’Hospitalet de Llobregat, Institut de Recerca OncolÒgica, Barcelona

    Miguel ángel Peinado

  5. Fundació Catalana de Gastroenterologia, Barcelona

    Ignacio Blanco

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  1. Judith Balmaña
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Correspondence to Judith Balmaña.

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Balmaña, J., Brunet, J., Pericay, C. et al. What is the hereditary non-polyposis colorectal cancer syndrome?. Rev Oncología 2, 191–201 (2000). https://doi.org/10.1007/BF02979554

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