Abstract
The treatment and follow-up strategies of patients with hereditary nonpolyposis colorectal carcinoma (HNPCC) were analyzed in 22 Finnish HNPCC families in systematic follow-up between 1983 and 1990. During the sevenyear study period metachronous colorectal neoplasia was diagnosed in 41 percent (15/37) of the patients treated by segmentai colonic resection and in 24 percent (4/17) of those treated by subtotal colectomy. Extracolonic carcinoma was diagnosed in 12 (30 percent) of the 40 patients during the long-term follow-up. The most common extracolonic malignancy was biliopancreatic carcinoma which accounted for all five cancer-related deaths in the whole series during the study period. It was concluded that subtotal colectomy is superior to hemicolectomy or segmental resection in HNPCC patients with colorectal carcinoma. A regular annual endoscopic follow-up of the residual rectum is still necessary, and surveillance for extracolonic cancers must be considered.
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This work was supported by the Finnish Cancer Society and the Foundation of Gastroenterological Research.
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Mecklin, JP., Järvinen, H. Treatment and follow-up strategies in hereditary nonpolyposis colorectal carcinoma. Dis Colon Rectum 36, 927–929 (1993). https://doi.org/10.1007/BF02050627
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DOI: https://doi.org/10.1007/BF02050627