Abstract
A furocoumarin derivative, psoralen (7H-furo[3,2-g][1]benzopyran-7-one), was isolated from the n-hexane fraction ofHeracleum moellendorffii Hance. We examined the effects of psoralen on a human Kv1.5 potassium channel (hKv1.5) cloned from human heart and stably expressed in Ltk cells. We found that psoralen inhibited the hKv1.5 current in a concentration-,use- and voltage-dependent manner with an IC50 value of 180 ± 21 nM at +60 mV. Psoralen accelerated the inactivation kinetics of the hKv1.5 channel, and it slowed the deactivation kinetics of the hKv1.5 current resulting in a tail crossover phenomenon. These results indicate that psoralen acts on the hKv1.5 channel as an open channel blocker. Furthermore, psoralen prolonged the action potential duration of rat atrial muscles in a dose-dependent manner. Taken together, the present results strongly suggest that psoralen may be an ideal antiarrhythmic drug for atrial fibrillation.
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An erratum to this article is available at http://dx.doi.org/10.1007/BF02969367.
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Eun, J.S., Choi, B.H., Park, J.A. et al. Open channel block of hKv1.5 by psoralen fromHeracleum moellendorffii hance. Arch Pharm Res 28, 269–273 (2005). https://doi.org/10.1007/BF02977790
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DOI: https://doi.org/10.1007/BF02977790