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General pharmacology of IY-80843, a new H2-receptor antagonist: Effects on the central nervous and cardiovascular systems

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Abstract

IY-80843, N-[2-(2-Methoxyphenyl)ethyl]-N′-[4-(Imidazole-4-yl) phenyl] formamidine, is a new potent H2-receptor antagonist. The potential secondary pharmacologic effects of this agent, on the central nervous and cardiovascular systems were studied. IY-80843 caused ptosis, suppression of locomotion, hypothermia, prolongation of sleeping time and hypotensive effects in mice, rats and dogs. These results suggest that IY-80843 affects the function of the central nervous and cardiovascular systems in a dose-dependent manner.

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Authors and Affiliations

  1. Korea Research Institute of Chemical Technology, Taedeog-Tanji, P.O. Box. 9, 305-606, Taejeon, Korea

    Eun Joo Kim, Hwa Sup Shin, Shi Yong Ryu & Byung Ho Lee

  2. Il Yang Pharmaceutical Co. Ltd., 182-4 Hagali, Ki Heung Eup, Young In Gun, Gyung Gi Do, Korea

    Soon Hyun Cho

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  1. Eun Joo Kim
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  2. Hwa Sup Shin
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  3. Shi Yong Ryu
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  4. Byung Ho Lee
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  5. Soon Hyun Cho
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Kim, E.J., Shin, H.S., Ryu, S.Y. et al. General pharmacology of IY-80843, a new H2-receptor antagonist: Effects on the central nervous and cardiovascular systems. Arch. Pharm. Res. 18, 1–7 (1995). https://doi.org/10.1007/BF02976498

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  • DOI: https://doi.org/10.1007/BF02976498

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