Activation of 5-HT1A receptors by their agonist 5-OH-DPAT (0.1, 0.5. and 1.0 mg/kg, i.p.) produced a significant and dose-dependent decrease in the number of headshakes mediated by 5-HT2A receptors, while blockade of 5-HT1A receptors by their antagonist WAT-100635 (0.5 and 1.0 mg/kg, i.p.), conversely, induced a significant increase in this functional response to 5-HT2A receptors. At the same time, activation of 5-HT2A receptors by their agonist DOI (0.5 and 1.0 mg/kg, i.p.) prevented the hypothermic response mediated by 5-HT1A receptors, while blockade of 5-HT2A receptors with ketanserin (1.0 and 2.0 mg/kg, i.p.) enhanced this functional response of 5-HT1A receptors. In addition, ketanserin (1.0 and 2.0 mg/kg, i.p. or 20 and 40 nmol, i.c.v.) induced a dose-dependent hypothermic response. This ketanserin (40 nmol, i.c.v.)-induced hypothermic response was significantly weakened by prior administration of the 5-HT1A receptor antagonist WAY-100635 (1.0 mg/kg, i.p.). This suggests that the hypothermic response evoked by blockade of 5-HT2A receptors is partially mediated by 5-HT1A receptors. These data point to the existence of a bidirectional functional interaction between 5-HT1A and 5-HT2A receptors, such that these receptors can support the mutual regulation of functional activity.
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Translated from Zhurnal Vysshei Nervnoi Deyatel’nosti imeni I. P. Pavlova, Vol. 65, No. 2, pp. 240–247, March–April, 2015. Original article submitted July 21, 2014. Accepted December 22, 2014.
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Naumenko, V.S., Bazovkina, D.V. & Kondaurova, E.M. Functional Interactions between 5-HT1A and 5-HT2A Receptors in the Brain. Neurosci Behav Physi 46, 783–788 (2016). https://doi.org/10.1007/s11055-016-0311-0
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DOI: https://doi.org/10.1007/s11055-016-0311-0