Abstract
In awake mobile rabbits, with electrodes implanted in the medial lemniscus, midbrain tegmental reticular nucleus, and pyramidal tract, combined stimulation of two brain structures resulted in elaboration of conditional connections in sensorimotor cortex neuronal populations. The main criterion of the conditioning was the appearance of changes in the neuronal activity on omission of the second stimulus. These changes represented a complex of electrical events, some of which were similar to and others different from the evoked responses to the second stimulus. Application of atropine, sulfate, chlorpromazine hydrochloride, serotonin creatinine sulfate, andγ-aminobutyric acid (GABA) to the cortex at the site of the recording exerted a modulating effect on the conditional neuronal activity patterns. Of the above substances, GABA and atropine had the most pronounced effect. The GABA removed the short-latency components of the conditional changes which were similar to evoked responses. The atropine abolished the long-latency changes which differed from evoked responses.
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Aprison, M. H., and Hingten, J. H. (1972) Serotonin and behaviour: A brief summary.Federation Proceedings, 31, 121–129.
Bevan, P., Bradshaw, C. M., and Szabadi, E. (1975) The antagonism of neuronal responses to acetylcholine by atropine: A quantitative study.Brain Research, 88, 568–571.
Burês, J., and Bureŝová, O. (1970) Plasticity in single neurons and neuronal population. In G. Horn, R. Hinde (Eds.),Short-Term Changes in Neural Activity and Behavior. Cambridge: University Press, pp. 363–403.
Chizhenkova, R. A. (1980) Organization of single unit responses in the sensorimotor cortex to combined stimulation of brain structures.Neuroscience and Behavioral Physiology, 10, 52–59.
Chizhenkova, R. A. (1986) Structural-function organization of sensorimotor cortex. Moscow: Nauka.
Deutsch, J. A. (1971) The cholinergic synapse and the site of memory.Science, 174, 788–794.
Glebov, R. N., and Kryzhanovsky, G. N. (1978) Functional biochemistry of synapses. Moscow: Meditsina.
Gromova, E. A. (1980) Emotional memory and its mechanisms. Moscow: Nauka.
Hebb, C. (1970) CNS of the cellular level: Identity of transmitter agents.Annual Review of Physiology, 32, 165–192.
Hurwitz, D. A., Robinson, S. M., and Baretsky, J. (1971) The influence of training and avoidance performance on disulfiram-induced changes in brain catecholamines.Neuropharmacology, 10, 447–452.
Huttenen, M. O. (1973) General model for the molecular events in synapse during learning.Perspectives in Biology and Medicine, 13, 103–108.
Ilyuchenok, R. Y. (1972) Pharmacology of behaviour and memory. Novisobirsk: Nauka.
John, E. R. (1967) Mechanism of memory. New York-London: Academic.
Kandel, E., and Spencer, W. (1968) Cellular neurophysiological approaches to study of learning.Physiological Review, 48, 65–134.
Koshtoyants, O. U., Antipina, M. Y., and Koltsova, A. V. (1979) Changes in ACh-sensitivity of sensorimotor cortex neurons during extinction of the conditioned reflex.Zhurnal Vysshey nervnoy Deyatelnosti, 29, 923–928.
Kotlyar, B. I. (1977)Mechanisms of Conditioning. Moscow: Moscow State University Press.
Krnjević, K. (1974) Chemical nature of synaptic transmission in vertebrates.Physiological Review, 54, 418–540.
Krnjević, K., Pumain, R., and Renaud, L. (1971) The mechanism of excitation by acetylcholine in the cerebral cortex.Journal of Physiology (Engl.), 215, 247–268.
Krnjević, K., and Schwartz, S. (1967) The action ofγ-aminobutyric acid on cortical neurones.Experimental Brain Research, 3, 320–336.
Kruglikov, R. Y. (1981) Neurochemical mechanisms of learning and memory. Moscow: Nauka.
Losev, N. A. (1979) Pharmacological analysis of neuron and EEG changes in system activity of the brain. In N. P. Bekhtereva (Ed.),Mechanisms of Memory Control. Leningrad: Nauka, pp. 68–72.
Mnukhina, R. S., and Samoylova, L. A. (1970) The mechanism of the inhibitory effect of chlorpromazine on the closure function of the cortex.Doklady An SSSR, 191, 253–256.
Quiron, R., Richard, J., and Dam, T. V. (1985) Evidence for the existence of serotonin type-2 receptors on cholinergic terminals in rat cortex.Brain Research, 333, 345–349.
Rabinovich, M. Y. (1975)The Closure Function of the Brain (Neuronal Mechanisms of Conditioning). Moscow: Meditsina.
Reader, T. A., Ferron, A., Descarries, L., and Jasper, H. H. (1979) Modulatory role for biogenic amines in the cerebral cortex; microiontophoretic studies.Brain Research, 160, 217–229.
Roberts, M. N. T., and Straugham, D. W. (1967) Excitation and depression of cortical neurones by 5-hydroxytryptamine.Journal of Physiology (Engl.), 193, 269–294.
Sakharov, D. A. (1979) Transmitters. In P. G. Kostjuk, A. I. Roytbak (Eds.),General Physiology of the Nervous System. Leningrad: Nauka, 213–277.
Schmidt, J., Rüthrich, H., and Kammerer, E. (1974) Plastic changes in the reaction of cortical neurons to sensory stimulation and putative transmitters. In H. Matthies (Ed.)Neurobiological Basis of Memory Formation, Berlin: pp. 262–270.
Schmidt, J., Rüthrich, H., and Werth, U. (1977) Effects of microiontophoretically applied putative transmitters on cortical neurons under conditioning.Activitas Nervosa Superior, 19, 162–163.
Segundo, J. P., and Bell, C. C. (1970) Habituation of single nerve cell in the vertebrate nervous system. In G. Horn, R. Hinde (Eds.),Short-Term Changes in Neural Activity and Behaviour. Cambridge: University Press, pp. 77–94.
Shulgina, G. I. (1978) Bioelectrical activity of the brain and conditioning. Moscow: Nauka.
Sokolov, E. N. (1981) Neuronal mechanisms of memory and learning. Moscow: Nauka.
Spehlmann, R., and Smathers, C. C. (1974) The effects of acetylcholine and of synaptic stimulation on the sensorimotor cortex of cats. II. Comparison of the neuronal responses to reticular and other stimuli.Brain Research, 74, 243–253.
Thompson, R. F., Patterson, M. M., and Teylor, T. J. (1972) The neurophysiology of learning.Annual Review of Physiology, 26, 73–104.
Vasilevsky, M. N. (1968) Neuronal mechanisms of cerebral cortex. Leningrad: Meditsina.
Vizi, E. S. (1980) Modulation of cortical release of acetylcholine by noradrenaline release from nerves arising from the rat locus coeruleus.Neuroscience, 5, 2139–2153.
Voronin, L. L. (1982) Analysis of plasticity of the central nervous system. Tbilisi: Metsniereba.
Waterhouse, B. D., and Woodward, D. J. (1980) Interaction by norepinephrine with cerebrocortical activity evoked by stimulation of somatosensory afferent pathways in the rat.Experimental Neurology, 67, 11–34.
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Chizhenkova, R.A. Pharmacological analysis of conditioning in sensorimotor cortex neurons in a model. Pav. J. Biol. Sci. 24, 11–18 (1989). https://doi.org/10.1007/BF02964526
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DOI: https://doi.org/10.1007/BF02964526