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Egg Yolk antibody and its application

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Abstract

A hen transfers her serum immumnoglobulin G to the egg yolk (IgY) and gives im|munity to her offspring. Therefore, the hen egg can be an effective supplier of a large amount of antigen specific antibody that accumulates in the egg yolk. Antigen specific antibody has been widely used for immunological analysis in the field of diagnosis as well as pure scientific research. The production and separation technology of IgY is demonstrated in the present study.

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References

  1. Burley, R. W. and D. V. Vadehra (1989) Eggs in human nutrition, pp. 351–364 In:The avain egg-chemistry and biology. Ed. R. W. Burley and D. V. Vadehra, John Wiley & Sons, New York, USA.

    Google Scholar 

  2. Polson, A, M. B. V. Wechmar, and G. Fazakerley (1980) Antibodies to proteins from yolk of immunized hens.Immunol. Comm. 9: 495–514.

    CAS  Google Scholar 

  3. Gardner, P. S. and S. Kaya (1982) Egg globulin in rapid virus diagnosis.J. Vitro. Meth. 4: 257–262.

    Article  CAS  Google Scholar 

  4. Kronvall, G., U. S. Seal, S. Sevensson and R. C. W. Jr. (1974) Phylogenetic aspect of Staphylococcal protein Areactive serum globulins in birds and mammalsActa. Path. Microbiol. Scand. Section B 82: 12–18.

    CAS  Google Scholar 

  5. Parvari, R., A. Avivi, F. Lentner, E. Ziv, S. Rel-Or, Y. Burstein, and I. Schechter (1988) Chicken immunoglobulin gheavy chains: Limited VH gene repertoire, combinatiorial diversification by D gene segments and evolution of the heavy chain locusEMBO J. 7: 739–744.

    CAS  Google Scholar 

  6. Ohta, M., J. Hamako, S. Yamamoto, H. Hatta, M. Kim, T. Yamamoto, S. Oka, T. Mizuochi and F. Matsuura (1991) Structures of asparagine-linked oligosaccharides from hen egg-yolk antibody (IgY). Occurrence of unusual glucosylated oligo-mannose type oligosaccharides in a mature glycoprotein.Clycoconjugate J. 8: 400–413.

    Article  CAS  Google Scholar 

  7. Jensenius, J. C., I. Anderson, J. Hau, M. Crone and C. Koch (1981) Conveniently packaged antibodies. Methods for purification of yolk IgC.J. Immunol. Meth. 46: 63–68.

    Article  CAS  Google Scholar 

  8. Cotestein, B. and E. Hemmeler (1985) Egg yolk immunoglobulin Y as an alternative antibody in the serology of echinococcosis.Z. Parasitenkd 71: 273–276.

    Article  Google Scholar 

  9. Bishop, R. E., G. P. Davidson, and B. J. Ruck (1973) Virus particles in epithelial cells of duodenal mucosa from children with acute nonbacterial gastroenteritis.Lancet 2: 1281–1283.

    Article  CAS  Google Scholar 

  10. Blacklow, N. R. and G. Cukor (1981) Viral gastroenteritis.N. Engl. J. Med. 304: 397–406.

    CAS  Google Scholar 

  11. Bartz, C. R., R. H., Conklin, C. B. Tunstall, and J. H. Stelle (1980) Prevention of murine rotavirus infection with chicken egg yolk immunoglobulinsJ. Infect. Dis. 142: 439–441.

    CAS  Google Scholar 

  12. Yolken, R. H., F. Leister, S. B. Wee, R. Miskuff, and S. Vonderfecht (1988) Antibodies to rotaviruses in chickens' eggs: A potential source of antiviral immunoglobulins suitable for human consumptionPediatrics 81: 291–295.

    CAS  Google Scholar 

  13. Ebina, T., K. Tukada, K. Umezu, M. Nose, K. Tsuda, H. Hatta, M. Kim, and T. Yamamoto (1990) Gastroenteritis in suckling mice caused by human rotavirus can be prevented with egg yolk immunoglobulin (IgY) and treated with a protein-bound polysaccharide preparation (PSK).Microbiol. Immunol. 34: 617–629.

    CAS  Google Scholar 

  14. Hatta, H., K. Tsuda, S. Akachi, M. Kim, and T. Yamamoto (1993) Productivity and some properties of egg yolk antibody (IgY) against human rotavirus compared with rabbit IgG.Biosci. Biotech. Biochem. 57: 450–454.

    CAS  Google Scholar 

  15. Hatta, H., K. Tsuda, S. Akachi, M. Kim, T. Yamamoto, and T. Ebina (1983) Dral passive immunization effect of antihuman rotavirus IgY and its behavior against proteolytic enzymes.Biosci. Biotech. Biochem. 57: 1077–1081.

    Article  Google Scholar 

  16. Loesche, W. J., J. Straffon, and P. J. Loos (1975) Association ofStreptococcus mutans with human dental decay.Infect. Immun. 11: 1252–1260.

    CAS  Google Scholar 

  17. Otake, S., Y. Nishihara, M. Makimura, H. Hatta, M. Kim, T. Yamamoto, and M. Hirasawa (1991) Protection of rats against dental caries by passive immunization with hen-egg-yolk antibody (IgY).J. Dent. Res. 70: 162–166.

    CAS  Google Scholar 

  18. Hatta H., K. Tsuda, M. Ozeki, M. Kim, T. Yamamoto, S. Otake, M. Hirasawa, J. Katz, N. K. Childers and S. M. Michalek (1997) Passive immunization against dental plaque formation in humans: Effect of a mouth rinse containing egg yolk antibodies (IgY) specific toStreptococcus mutans.Caries Res. 31: 268–274.

    Article  CAS  Google Scholar 

  19. Marshall, B. J. and J. R. Warren (1984) Unidentified curved bacilli in the stomach of patients with Castritis and peptic ulceration.Lancet 8390: 1311–1315.

    Article  Google Scholar 

  20. Japanese patent application (1991) 3–120693.

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Authors and Affiliations

  1. Graduate School of Biotechnology, Korea University, 136-701, Seoul, Korea

    Mujo Kim, Han-Chul Yang & Hong-Yon Cho

  2. Pharma Foods International, Kyoto, Japan

    Shinji Higashiguchi & Yoshitomo Iwamoto

  3. Department of Food Nutrition, Kyoto Women's University, Kyoto, Japan

    Hajime Hatta

Authors
  1. Mujo Kim
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  2. Shinji Higashiguchi
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  3. Yoshitomo Iwamoto
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  4. Han-Chul Yang
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  5. Hong-Yon Cho
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  6. Hajime Hatta
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Correspondence to Mujo Kim.

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Kim, M., Higashiguchi, S., Iwamoto, Y. et al. Egg Yolk antibody and its application. Biotechnol. Bioprocess Eng. 5, 79–83 (2000). https://doi.org/10.1007/BF02931876

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  • DOI: https://doi.org/10.1007/BF02931876

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