Skip to main content
SpringerLink
Log in

Clinical expression of airway hyperreactivity in adults

  • Published:
Clinical Reviews in Allergy Aims and scope Submit manuscript

Abstract

Airway hyperreactivity is a common feature in patients with asthma and chronic airflow obstruction. Although the intensity of airway reactivity and the degree of airflow obstruction are generally related to eachother, airway hyperreactivity is not an epiphenomenon of airflow obstruction. Apparently, bronchodilator therapy is also important in patients with irreversible airflow obstruction since it may prevent sudden bronchoconstriction after contacts with nonspecific irritants.

As airway hyperreactivity does not discriminate between asthma and chronic airflow obstruction, this may suggest that they are two aspects of the same basic process with airway hyperreactivity as one common denominator. Other factors, however, should not be disregarded.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Hargreave, F. E., Ryan, G., Thomson, N. C., O’Byrne, P. M., Latimer, K., Juniper, E. F., and Dolovich, J. (1981),J. Allergy Clin. Immunol. 68, 347–355.

    Article  PubMed  CAS  Google Scholar 

  2. Boushey, H. A., Holtzman, M. J., Sheller, J. R., and Nadel, J. A. (1980),Am. Rev. Respir. Dis. 121, 389–413.

    PubMed  CAS  Google Scholar 

  3. Curry, J. J. (1947),J. Clin. Invest. 26, 430–438.

    Article  PubMed  CAS  Google Scholar 

  4. Cockcroft, D. W., Ruffin, R. E., Frith, P. A., Cartier, A., Juniper, E. F., Dolovich, J., and Hargreave, F. E. (1979),Am. Rev. Respir. Dis. 120, 1053–1058.

    PubMed  CAS  Google Scholar 

  5. O’Byrne, P. M., Ryan, G., Morris, M., McCormack, D., Jones, N. L., Morse, J. L. C., and Hargreave, F. E. (1982),Am. Rev. Respir. Dis. 125, 281–285.

    PubMed  CAS  Google Scholar 

  6. Juniper, E. F., Frith, P. A., and Hargreave, F. E. (1982),Thorax 37, 288–291.

    PubMed  CAS  Google Scholar 

  7. de Vries, K., Booij-Noord, H., and Goei, J. T. (1964), Hyperreactivity of the Bronchial Tree to Drugs, Chemical, and Physical Agents (Orie, N. G. M. and Sluiter, H. J., eds.),Bronchitis Vol.2, Van Gorcum, Assen, pp. 167–180.

    Google Scholar 

  8. Cockcroft, D. W. (1985),Ann. Allergy 55, 527–534.

    PubMed  CAS  Google Scholar 

  9. Eiser, N. M., Kerrebijn, D. F., and Quanjer, P. H. (1983),Bull. Eur. Physiopathol. Respir. 19, 495–514.

    Google Scholar 

  10. Bahous, J., Cartier, A., Ouimet, G., Pineau, L., and Malo, J. L. (1984),Am. Rev. Respir. Dis. 129, 216–220.

    PubMed  CAS  Google Scholar 

  11. Klein, R. C. and Salvaggio, J. E. (1966),J. Allergy 37, 158–168.

    Article  PubMed  CAS  Google Scholar 

  12. Yan, K., Salome, C. M., and Woolcock, A. J. (1985),Am. Rev. Respir. Dis. 132, 25–29.

    PubMed  CAS  Google Scholar 

  13. Fanta, C. H. and Ingram, R. H. (1951),Med. Clin. North. Am. 65, 473–487.

    Google Scholar 

  14. Higgenbottam, T., Feyerband, C., and Clark, T. J. M. (1980),Thorax 35, 246–254.

    Google Scholar 

  15. Ramsdell, J. W., Nachtwey, F. J., and Moser, K. M. (1982),Am. Rev. Respir. Med. 126, 829–832.

    CAS  Google Scholar 

  16. Skoogh, B. E. (1973),Scand. J. Respir. Dis. 54, 379–387.

    PubMed  CAS  Google Scholar 

  17. Du Toit, J. L., Woolcock, A. J., Salome, C. M., Sundrum, R., and Black, J. L. (1986),Am. Rev. Respir. Dis. 134, 498–501.

    PubMed  CAS  Google Scholar 

  18. Pride, N. (1986),Clin. Allergy 16, 3–6.

    Article  PubMed  CAS  Google Scholar 

  19. Orie, N. G. M., Sluiter, H. J., de Vries, K., Tammeling, G. J., and Witkop, J. (1960), The Host Factor in Bronchitis,Bronchitis, Int. Symposium Groningen, Van Gorcum, Assen. pp. 43–59.

    Google Scholar 

  20. Van der Lende, R., De Kroon, J. P. M., Van der Meulen, G. G., Tammeling, G. J., Visser, B. F., de Vries K., Orie, N. G. M. (1970), Possible Indicators of Endogenous Factors in the Development of CNSLD (Orie, N. G. M. and Van der Lende, R., eds.),Bronchitis Vol. 3, Int. Symposium Groningen, Van Gorcum, Assen pp. 52–70.

    Google Scholar 

  21. Gökemeyer, J. D. M. (1970), Hyperreactiviteit van de Luchtwegen, Thesis, Wolters-Noordhoff, Groningen.

  22. de Vries, K., Gökemeyer, J. D. M., Koe’tër, G. H., de Monchy, J. G. R., van Bork, L. E., Kauffman, H. F., and Meurs, H. (1982), Cholinergic and Adrenergic Mechanisms in Bronchial Hyperreactivity (Morley, J., ed.),Perspectives in Asthma, Vol. 1.Bronchial Hyperreactivity, Academic, New York, NY, pp. 107–121.

    Google Scholar 

  23. Postma, D. S., de Vries, K., and Sluiter, H. J. (1986),Neth. J. Med. 29, 334–341.

    PubMed  CAS  Google Scholar 

  24. Ramsdale, E. H., Roberts, R. S., Morris, M. M., and Hargrave, F. E. (1985),Thorax 40, 422–426.

    PubMed  CAS  Google Scholar 

  25. Juniper, E. F., Frith, P. A., and Hargreave, F. E. (1981),Thorax 36, 575–579.

    PubMed  CAS  Google Scholar 

  26. Cockcroft, D. W., Dillian, D. N., Mellon, J. J. A., and Hargreave, F. E. (1977),Clin. Allergy 7, 235–243.

    Article  PubMed  CAS  Google Scholar 

  27. Townley, R. G., Ryo, U. Y., Kolotkin, B. M., and Kang, B. (1975),J. Allergy Clin. Immunol. 56, 429–442.

    Article  PubMed  CAS  Google Scholar 

  28. Ryan, G., Latimer, K. M., Dolovich, J., and Hargreave, F. E. (1982),Thorax 37, 423–429.

    Article  PubMed  CAS  Google Scholar 

  29. Makino, S. (1966),J. Allergy 38, 127–142.

    Article  PubMed  CAS  Google Scholar 

  30. Dales, R. E., Ernst, P., Hanley, J. A., Battista, R. N., and Becklake, M. R. (1987),Am. Rev Respir. Dis. 135, 817–821.

    PubMed  CAS  Google Scholar 

  31. Rubinfeld, A. R. and Pain, M. C. F. (1977),Am. Rev. Respir. Dis. 115, 381–387.

    PubMed  CAS  Google Scholar 

  32. Burdon, J. G. W., Juniper, E. F., Eillian, K. J., Hargreave, F. E., and Campbell, E. J. M. (1982),Am. Rev. Respir. Dis. 115, 381–387.

    Google Scholar 

  33. Spector, S. L. and Farr, R S. (1975),J. Allergy Clin. Immunol. 56, 308–316.

    Article  PubMed  CAS  Google Scholar 

  34. Booij-Noord, H., de Vries, K., Sluiter, H. J., and Orie, N. G. M. (1972),Clin. Allergy 2, 43–61.

    Article  PubMed  CAS  Google Scholar 

  35. Eillian, D., Cockcroft, D. W., Hargreave, F. E., and Dolovich, J. (1976),Clin. Allergy 6, 219–225.

    Article  Google Scholar 

  36. Bryant, D. H. and Burns, M. W. (1976),Clin. Allergy 6, 523–532.

    Article  PubMed  CAS  Google Scholar 

  37. de Monchy, J. G. R. (1986),The Late Allergic Reaction in Bronchial Asthma, Thesis, Krips Repro. Meppel, the Netherlands.

  38. Neijens, H. J. and Kerrebijn, K. F. (1983),Eur. J. Respir. Dis. 64, 591–597.

    PubMed  CAS  Google Scholar 

  39. Empey, D. W., Laitinen, L. A., Jacobs, L., Gold, W. M., and Nadel, J. A. (1976),Am. Rev. Respir. Dis. 113, 131–139.

    PubMed  CAS  Google Scholar 

  40. Cockcroft, D. W., Ruffin, R. E., Dolovich, J., and Hargreave, F. E. (1977),Clin. Allergy 7, 503–513.

    Article  PubMed  CAS  Google Scholar 

  41. Löwhagen, O. and Rak, S. (1985),J. Allergy Clin. Immunol. 75, 460–467.

    Article  PubMed  Google Scholar 

  42. Sotomayer, H., Badier, M., Vervloet, D., and Orehek, J. (1984),Am. Rev. Respir. Dis. 130, 56–58.

    Google Scholar 

  43. Thorpe, J. E., Steinberg, P., Bernstein, J. L., and Murlas, C. G. (1987),Chest 91, 21–25.

    Article  PubMed  CAS  Google Scholar 

  44. Cartier, A., Thomson, N. C., Frith, P. A., Roberts, R., and Hargreave, F. E. (1982),J. Allergy Clin. Immunol. 70, 170–177.

    Article  PubMed  CAS  Google Scholar 

  45. Durham, S. R., Graneek, B. J., Hawkins, R., and Newman Taylor, A. J. (1987),J. Allergy Clin. Immunol. 79, 398–406.

    Article  PubMed  CAS  Google Scholar 

  46. Cockcroft, D. W., Cotton, D. J., and Mink, J. T. (1979),Am. Rev. Respir. Dis. 119, 505–510.

    PubMed  CAS  Google Scholar 

  47. Chan-Yeung, M. (1977),Am. Rev. Respir. Dis. 116, 1023–1031.

    PubMed  CAS  Google Scholar 

  48. Koëter, G. H., Meurs, H., Kauffman, H. F., and de Vries, K. (1982),Eur. J. Respir. Dis. 63, 72–78.

    Google Scholar 

  49. Durham, S. R. and Kay, A. B. (1985),Clin. Allergy 15, 411–418.

    Article  PubMed  CAS  Google Scholar 

  50. de Monchy, J. G. R., Kauffman, H. F., Venge, P., Koëter, G. H., Jansen, H. M., Sluiter, H. J., and de Vries, K. (1985),Am. Rev. Respir. Dis. 131, 373–377.

    PubMed  CAS  Google Scholar 

  51. Bruijnzeel, P. L. B., de Monchy, J. G. R., Verhagen, J., and Kauffman, H. F. (1986),Bull. Eur. Physiopathol. Resp. 22, 54–61.

    CAS  Google Scholar 

  52. Kraan, J., Koëter, G. H., Van der Mark, Th. W., Sluiter, H. J., and de Vries, K. (1985),J. Allergy Clin. Immunol. 76, 628–639.

    Article  PubMed  CAS  Google Scholar 

  53. Holtzman, M. J., Cunningham, J. H., Sheller, J. H., Irsigler, G. B., Nadel, J. A., and Boushey, H. A. (1979),Am. Rev. Respir. Dis. 120, 1059–1067.

    PubMed  CAS  Google Scholar 

  54. Golden, J. A., Nadel, J. A., and Boushey, H. A. (1978),Am. Rev. Respir. Dis. 118, 287–294.

    PubMed  CAS  Google Scholar 

  55. O’Byrne, R. M. Walters, E. H., and Gold, B. D. (1984),Am. Rev. Respir. Dis. 130, 214–219.

    PubMed  CAS  Google Scholar 

  56. O’Byrne, R. M., Walters, E. H., Aizawa, H., Fabbri, L. M., Holtzman, M. J., and Nadel, J. A. (1984),Am. Rev. Respir. Dis. 130, 220–224.

    PubMed  CAS  Google Scholar 

  57. Postma, D. S., Renkema, T. E. J., Noordhoek, J. A., Faber, H., Sluiter, H. J., and Kauffman, H. (1988),Am. Rev. Respir. Dis. 137, 57–62.

    PubMed  CAS  Google Scholar 

  58. Neijens, H. J., Raatgreep, R. E., Degenhart, H. J., Duiverman, E. J., and Kerrebijn, K. F. (1984),Am. Rev. Respir. Dis. 130, 744–747.

    PubMed  CAS  Google Scholar 

  59. Ahmed, T. and Machette, B. (1985),Am. Rev. Respir. Dis. 132, 839–844.

    PubMed  CAS  Google Scholar 

  60. de Vries, K., Goei, J. T., Booij-Noord, H., and Orie, N. G. M. (1962),Int. Arch. Allergy 20, 93–101.

    PubMed  CAS  Google Scholar 

  61. Tammeling, C. J., de Vries, K., and Kruyt, E. N. (1977), The Circadian Pattern of the Bronchial Reactivity to Histamine in Healthy Subjects and in Patients with Obstructive LungDisease, (McGovern, J. P., ed.),Chronobiology in Allergy and Immunology, C C Thomas, Springfield, IL, pp. 139–149.

    Google Scholar 

  62. Platts-Mills, T. A. E., Mitchell, E. B., Nock, P., Tovey, E. R., Moszoro, H., and Wilkins, S. R. (1982),Lancet 2, 675–677.

    Article  PubMed  CAS  Google Scholar 

  63. Sluiter, H. J., Orie, N. G. M., Vegter, J. J. M., and Tammeling, C. J. (1961), Emphysema and Cor Pulmonale (Orie, N. G. M. and Sluiter, H. J., eds.),Bronchitis, Van Gorcum, Assen.

    Google Scholar 

  64. Van Aalderen, W. M. C., Postma, D. S., Koëter, G. H., and Knol, K. (1987),Proc. Int. Congress on Chronobiology, Leiden, the Netherlands.

    Google Scholar 

  65. Welty, C., Weiss, S. T., Tager, I. B., Munoz, A., Becker, C., Speizer, F. E., and Ingram, R. H., Jr. (1984),Am. Rev. Respir. Dis. 130, 198–203.

    PubMed  CAS  Google Scholar 

  66. Gerrard, J. W., Cockcroft, D. W., Mink, J. T., Cotton, D. J., Poomawala, R. P., and Dosman, J. A. (1980),Am. Rev. Respir. Dis. 122, 577–581.

    PubMed  CAS  Google Scholar 

  67. Taylor, R. G., Joyce, H., Gross, E., Holland, F., and Pride, N. B. (1985),Thorax 40, 9–16.

    PubMed  CAS  Google Scholar 

  68. Buczko, G. B., Day, A., Vanderdoelen, J. L., Boucher, R., and Zamel, N. (1984),Am. Rev. Respir. Dis. 129, 12–14.

    PubMed  CAS  Google Scholar 

  69. Bosse, R., Sparrow, D., Rose, C. L., and Weiss, S. T. (1981),Am. Rev. Respir. Dis. 123, 378–381.

    PubMed  CAS  Google Scholar 

  70. Barter, C. E. and Campbell, A. H. (1976),Am. Rev. Respir. Dis. 113, 305–314.

    PubMed  CAS  Google Scholar 

  71. Postma, D. S., de Vries, K., Koëser, G. H., and Sluiter, H. J. (1986),Am. Rev. Respir. Dis. 134, 276–280.

    PubMed  CAS  Google Scholar 

  72. Request for Proposal CEP-NHLBI-84-1 (1983),Early Intervention for Chronic Obstructive Pulmonary Disease, National Institutes of Health, National Heart, Lung, and Blood Institute, Bethesda, MD.

    Google Scholar 

  73. Peat, J. K. Woolcock, A. J., and Culen, K. (1987),Eur. J. Respir. Dis. 70, 171–179.

    PubMed  CAS  Google Scholar 

  74. Gerritsen, J., Koëter, G. H., Van Aalderen, W. M. C., and Knol, K. (1987),Am. Rev. Respir. Dis. 135, A311.

    Google Scholar 

  75. Bleecker, E. R. (1985),J. Allergy Clin. Immunol. 75, 21–24.

    Article  PubMed  CAS  Google Scholar 

  76. University Hospitals Groningen and Rotterdam, Multicentre Study,Long-term Intervention in Asthma and Chronic Airflow Obstruction, unpublished data.

Download references

Author information

Authors and Affiliations

  1. Departments of Pulmonology and Allergology, State University Hospital, 9713 EZ, Groningen, The Netherlands

    Dirkje S. Postma, Gerard H. Koëter & Klaas de Vries

Authors
  1. Dirkje S. Postma
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gerard H. Koëter
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Klaas de Vries
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Postma, D.S., Koëter, G.H. & Vries, K.d. Clinical expression of airway hyperreactivity in adults. Clinical Reviews in Allergy 7, 321–343 (1989). https://doi.org/10.1007/BF02914481

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02914481

Keywords

Search

Navigation