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Normal mitotic reactivity of fibroblasts and mesothelial cells in thrombocytopenic rat

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Virchows Archiv B Cell Pathology Including Molecular Pathology

Summary

Mitotic reactivity following 48/80-induced mast-cell secretion was studied in the mesentery of rats made thrombocytopenic, 7 days following a single injection of melphalan. In spite of a low platelet count (7% of normal), the mitogenic reaction of the mesenteric fibroblasts and mesothelial cells was normal as judged by DNA-synthesis and mitotic index.

The findings suggest that platelets and platelet-growth factors are not essential for the mast-cell-mediated mitogenic reaction of these two types of connective-tissue cells studied in vivo.

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Authors and Affiliations

  1. Department of Pathology II, University of Linköping, and State Institute of Forensic Medicine, Linköping, Sweden

    Klas Norrby & Lennart Rammer

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  1. Klas Norrby
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  2. Lennart Rammer
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Supported by grants from the Swedish Medical Research Council, Project 5942

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Norrby, K., Rammer, L. Normal mitotic reactivity of fibroblasts and mesothelial cells in thrombocytopenic rat. Virchows Archiv B Cell Pathol 42, 185–192 (1983). https://doi.org/10.1007/BF02890381

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  • DOI: https://doi.org/10.1007/BF02890381

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