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Platelets, prostaglandins and inflammation

  • Immunosuppression and Inflammation
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Abstract

In exudates of implanted sponges in rats, made thrombocytopenic by the administration of anti-platelet serum, there are significant reductions in the platelet and leucocyte counts and of the content of prostaglandin-like activity. It is concluded that platelets migrate into the developing sponge exudates, are the source of the prostaglandins and interact with complement to cause leucocyte migration. In normal animals the administration of indomethacin and sodium salicylate cause similar effects to thrombocytopenia whereas the injection of human plasma fraction affects only the leucocyte migration. One of the sites of the anti-inflammatory action of conventional non-steroidal drugs may be concerned with the migration of platelets into inflammatory lesions.

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References

  1. J.F. Mustard andM.A. Packham,Platelets, Thrombosis and Drugs, Drugs9, 19–76 (1975).

    PubMed  Google Scholar 

  2. F.H. Valone, F.K. Austen andE.J. Goetzl,Modulation of the Random Migration of Human Platelets, J. clin. Invest.54, 1100–1106 (1974).

    PubMed  Google Scholar 

  3. M.J. Silver, J.B. Smith andC.M. Ingerman,Blood Platelets and the Inflammatory Process, Agents and Actions4, 233–239 (1974).

    Article  PubMed  Google Scholar 

  4. B.B. Weksler andC.E. Coupal,Platelet-Dependent Generation of Chemotactic Activity in Serum, J. exp. Med.137, 1419–1430 (1973).

    Article  PubMed  Google Scholar 

  5. W. Margaretten andD.G. McKay,The Requirement for Platelets in the Active Arthus Reaction, Am. J. Path.64, 257–263 (1971).

    PubMed  Google Scholar 

  6. F.B. Ubatuba, E.A. Harvey andS.H. Ferreira,Are Platelets Important in Inflammation? Agents and Actions5, 31–34 (1975).

    Article  PubMed  Google Scholar 

  7. M.J.H. Smith andA.W. Ford-Hutchinson,An Anti-Inflammatory Substance in Normal Human Plasma, Agents and Actions5, 318–321 (1975).

    PubMed  Google Scholar 

  8. J.R. Walker, M.J.H. Smith, A.W. Ford-Hutchinson andF.J. Billimoria,Mode of Action of an Anti-Inflammatory Fraction from Normal Human Plasma, Nature254, 444–446 (1975).

    Article  PubMed  Google Scholar 

  9. A.W. Ford-Hutchinson, M.J.H. Smith, P.N.C. Elliott, J.P. Bolam, J.R. Walker, A.A. Lobo, J.K. Badcock, A.J. Colledge andF.J. Billimoria,Effects of a Human Plasma Fraction on Leucocyte Migration into Inflammatory Exudates, J. Pharm. Pharmac.27, 106–112 (1975).

    Google Scholar 

  10. A.W. Ford-Hutchinson, P.N.C. Elliott, J.P. Bolam andM.J.H. Smith,The Effects of a Human Plasma Fraction on Carrageenan-Induced Paw Oedema in the Rat, J. Pharm. Pharmac.26, 878–881 (1974).

    Google Scholar 

  11. N.P. Siemensma, P.S. Bathal andD.G. Penington,The Effect of Massive Liver Resection on Platelet Kinetics in the Rat, J. Lab. clin. Med.86, 817–833 (1975).

    PubMed  Google Scholar 

  12. J.R. Walker, M.J.H. Smith andA.W. Ford-Hutchinson,Anti-Inflammatory Drugs, Prostaglandins and Leucocyte Migration, Agents and Actions6, in press (1976).

  13. M. Hamberg, J. Svensson andB. Samuelsson,Thromboxanes: A New Group of Biologically Active Molecules Derived from Prostaglandin Endoperoxides, Proc. nat. Acad. Sci. USA72, 2994–2998 (1975).

    PubMed  Google Scholar 

  14. B.B. Weksler,The Platelet in Inflammation: Interaction with Complement to Promote Chemotaxis, in:Platelets: Production, Function, Transfusion and Storage (Eds M.G. Baldini and S. Ebbe, Grune and Stratton, New York 1974), p. 277–285.

    Google Scholar 

  15. A. Janoff,Neutrophil Proteases in Inflammation, Ann. Rev. Med.23, 177–190 (1972).

    Article  PubMed  Google Scholar 

  16. S.H. Ferreira, F.B. Ubatabu andJ.R. Vane,Platelets, Acute Inflammation and Inflammatory Mediators, in:Future Trends in Inflammation II (Eds J.P. Giroud, D.A. Willoughby and G.P. Velo, Birkhäuser Verlag, Basel 1975), p. 313–319.

    Google Scholar 

  17. B.B. Vargaftig, see [16];, Discussion, p. 318.

    Google Scholar 

  18. K. D. Butler, G. F. Pay andA.M. White,A Comparison between Sulphinpyrazone and Other Drugs on the Thrombocytopenia Occurring in the Arthus Reaction in the Guinea-Pig, Br. J. Pharmac. (in press).

  19. T.T. Odell, Jr., T.P. McDonald andF.L. Howsden,Native and Foreign Stimulators of Platelet Production, J. Lab. clin. Med.64, 418–424 (1964).

    PubMed  Google Scholar 

  20. M.A. Bray andD. Gordon,Effects of Anti-Inflammatory Drugs on Macrophage Prostaglandin Biosynthesis, Br. J. Pharmac.57, 466–464P (1976).

    Google Scholar 

  21. A. L. Willis, P. Davison, P.W. Ramwell, W.E. Brocklehurst andB. Smith,Release and Actions of Prostaglandins in Inflammation and Fever, Inhibition by Anti-Inflammatory and Antipyretic Drugs, in:Prostaglandins in Cellular Biology (Eds P.W. Ramwell and B.B. Pharriss, Plenum Press, New York 1972), p. 227 to 259.

    Google Scholar 

  22. F.H. Valone, K.F. Austen andE.J. Goetzl,Inhibition by Aspirin of the Enhanced Migration of Human Platelets in Response to Prostaglandin Precursors, Immun. Commun.4, 139–148 (1975).

    Google Scholar 

  23. G. de Gabriele andD.G. Penington,Regulation of Platelet Production: Hypersplenism in the Experimental Animal, Br. J. Haemat.13, 384–393 (1967).

    Google Scholar 

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Authors and Affiliations

  1. Department of Biochemical Pharmacology, King's College Hospital Medical School, Denmark Hill, SE5, London, UK

    M. J. H. Smith, J. R. Walker & A. W. Ford-Hutchinson

  2. Department of Medicine, St. Vincent's Hospital, University of Melbourne, 3056, Melbourne, Australia

    D. G. Penington

Authors
  1. M. J. H. Smith
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  2. J. R. Walker
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  3. A. W. Ford-Hutchinson
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  4. D. G. Penington
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Smith, M.J.H., Walker, J.R., Ford-Hutchinson, A.W. et al. Platelets, prostaglandins and inflammation. Agents and Actions 6, 701–704 (1976). https://doi.org/10.1007/BF02026091

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