Summary
A histological and ultrastructural observation of CHA implanted intra muscularly and subcutaneously had been reported. Our results showed that a mild inflammation developed at the early stage and disappeared 2 weeks after implantation. The infiltrating cells were mainly monocyte-macrophages, a number of fibroblasts followed macrophags closely. It was possible that as CHA degrades, monocyte-macrophages continuously released inflammatory factors, thus enhanc ing fibroblast proliferation activity and tissue regeneration. In addition, the het erotopic calcification of collagen matrix was observed, suggesting that CHA pro moted calcification deposition.
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This project was supported by the National Natural Science Foundation of China (No. 38970717).
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Zhidao, X., Tongbo, Z., Jingyuan, D. et al. Tissue response and the cytoconduction ability to collagen/ hydroxyapatite heterotopic implantation. Current Medical Science 17, 118–122 (1997). https://doi.org/10.1007/BF02888249
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DOI: https://doi.org/10.1007/BF02888249