Summary
Before and after oral administration of ligustrazine controlled release capsule, pulmonary hemodynamics, right cardiac function, arterial blood gas and TXB2/6-keto-PGF1α were studied in 16 patients with advanced cor pulmonale. The decrease of pulmonary arterial pressure and pulmonary vascular resistance, increase of cardiac output, improvement of right cardiac function and arterial blood gas were demonstrated after one course of treatment. The mechanism of these effects may be related to improvement of imbalance of TXB2/6-keto-PGF1α. These results were in agreement with those of intravenous administration of ligustrazine, but no adverse reactions were found.
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References
Peng W, Duan SF. Hemodynamic and hemorrheologic effect of ligustrazine in chronic obstructive pulmonary disease with cor pulmonale. Chin Med J 1987;100:965–70.
1985; 5:291–4
A2, MDA 1987; 10:80–2.
(1989)
1989; 5:26–31.
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Wei, P., Sheng-fu, D. Effects of ligustrazine controlled release capsule in chronic pulmonary heart disease. Journal of Tongji Medical University 11, 101–105 (1991). https://doi.org/10.1007/BF02888096
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DOI: https://doi.org/10.1007/BF02888096