Skip to main content
SpringerLink
Log in

Evaluation of blood studies in diagnosis of diseases of the liver

  • Original Contributions
  • Published:
The American Journal of Digestive Diseases

Conclusion

  1. 1.

    A survey has been made of a large series of cases in which the clinical status of the liver was evaluated by the determination of the prothrombin time, A/G ratio, the cephalin and zinc flocculation tests, the thymol turbidity test, the gamma globulin content, the blood bilirubin, the blood cholesterol and the alkaline phosphatase.

  2. 2.

    The cephalin flocculation test was found to be the least sensitive of the flocculation tests. In general the flocculation tests were very effective in detecting dysfunction of the liver cells and correlated closely with disturbance of the albumin/globulin ratio when this was present.

  3. 3.

    Elevated bilirubin and alkaline phosphatase were frequently found together.

  4. 4.

    The least valuable tests in this series were the A/G ratio and the determination of the serum cholesterol, both total and esterified.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Bodansky, A.: Notes on the Determination of Serum Inorganic Phosphate and of Serum Phosphatase Activity. Amer. Jour. Clin. Path., Tech. Suppl., 7: 51–59, 1937.

    CAS  Google Scholar 

  2. De La Huerga, J. and Popper, H.: Estimation of Gamma Globulin by Turbidity. Jour, of Lab. and Cliu. Med., 35: 459–465, 1950.

    Google Scholar 

  3. Franklin, M., Popper, H., Steigmann, F. and Kozell, D.: Relation between Structural and Functional Alterations of the liver. Jour. of Lab. and Clin. Med., 33: 435–447, 1948.

    CAS  Google Scholar 

  4. Greene, C. H.: Liver and Biliary Tract. Arch. Int. Med., 86: 743–788, Nov. 1950.

    CAS  Google Scholar 

  5. Hanger, F. M.: Serologic Differentiation of Obstructive from Hepatogenous Jaundice by Flocculation of Cephalin Cholesterol Emulsion. Jour. of Clin. Investigation, 18:261–269, 1939.

    Article  CAS  Google Scholar 

  6. Kunkel, H. G.: Estimation of Alterations of Serum Gamma Globulin by a Turbidimetric technique. Proc. Soc. Exper. Biol. and Med., 66: 217, 1947.

    CAS  Google Scholar 

  7. Maclagan, N. F.: Thymol Turbidity Test; a new indicator of liver dysfunction. Nature, London 154: 670–671, 1944.

    Article  CAS  Google Scholar 

  8. Quick, A. J.: Determination of Prothrombin. Proc. Exper. Biol. and Med., 42: 788–789, 1939.

    CAS  Google Scholar 

  9. Rafsky, H. A., Weingarten, M., Krieger, C. I., Stern, K. G., Newman, B.: Electrophoretic Studies in Liver Disease. Gastroenterology, 14: 29–39, 1950.

    PubMed  CAS  Google Scholar 

  10. Schalm, L., and Schulte, M. J.: The Quantitative Determination of the Two Types of Bilirubin Simultaneously Present in the Blood, and its Clinical Importance. Amer. Jour. of Med. Scien., 219: 606–616, 1950.

    Article  CAS  Google Scholar 

  11. Scheftel, A. G.: Determination of Total and Free Cholesterol. Jour, of Lab. and Clin. Med., 29: 877, 1944.

    Google Scholar 

  12. Watson, C. J. and Rappaport, E. M.: Comparison of Results of Cephalin and Thymol Tests. Jour. of Lab. and Clin. Med., 30: 893, 1945.

    Google Scholar 

  13. Weichselbaum, T. E.: An accurate and rapid method for the determination of Protein in small amounts of blood and plasma. Amer. Jour. of Clin. Path., Tech. Suppl., 16: 40, 1946.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Laboratory, U. S. Marine Hospital, Staten Island, N. Y.

    Lawrence H. Sophian & Valentine J. Connolly

Authors
  1. Lawrence H. Sophian
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Valentine J. Connolly
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sophian, L.H., Connolly, V.J. Evaluation of blood studies in diagnosis of diseases of the liver. Amer. Jour. Dig. Dis. 19, 44–47 (1952). https://doi.org/10.1007/BF02876294

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02876294

Keywords

Search

Navigation