Abstract
The cycloaddition of the newely synthesized 5-(2-thienyl)methylene derivatives of thiazolidinone-4-thiones,2a−c to acrylonitrile (3a), ethyl acrylate (3b), N-phenylmaleimide (6) and dimethyl fumarate (8) has been evaluated. Under thermal reaction conditions [4+2] cycloaddition proceeds with complete site and regioselectivity to yield the cycloadduct,4, 5, 7 and9, respectively. The antimicrobial activities of some of the new products were tested.
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Ead, H.A., Metwalli, N.H. & Morsi, N.M. Cycloaddition reactions of 5-(2-thienyl)methylene derivatives of thiazolidinone-4-thiones and their antimicrobial activities. Arch. Pharm. Res. 13, 5–8 (1990). https://doi.org/10.1007/BF02857825
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DOI: https://doi.org/10.1007/BF02857825