Abstract
To develop potent antitumor polysaccharides from higher fungi of Korea the alcohol precipitated polysaccharides, which were obtained from hot water extracts of shake-cultured mycelia of eight species of basidiomycetes, were subjected to antitumor screening tests, using sarcoma 180 as a tumor cell. When administeredi.p., at the dose level of 20mg/kg/day for ten days into the mice which were implanted with 1×106 cells of sarcoma 180 twenty-four hour before the start of polysaccharide injection, the polysaccharides ofPluteus cervinus ISA-Pc-1004,Pleurotus pulmonarius, Hydnum repandum ISA-Hr-1006, andLaccaria laccata ISA-L1-1008 respectively showed inhibition ratios of 62.0%, 51.7%, 64.8%, and 57.8%. They were selected for further study, while those ofPanellus serotina ISA-Ps-1012,Laccaria amethystina ISA-La-1001,Pholiota adiposa ISA-Pa-1010, andLepista sp. ISA-Ls-1007 respectively showed inhibition ratios of −9.3%, 25.3%, 27.3%, and 33.0%.
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Chung, K.S., Choi, E.C., Kim, B.K. et al. Studies on the constituents and culture of Korean basidiomycetes. Arch. Pharm. Res. 5, 17–19 (1982). https://doi.org/10.1007/BF02856359
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DOI: https://doi.org/10.1007/BF02856359