Summary
The distinction of antimicrobial resistance of clinical bacteria isolated from county hospitals and a teaching hospital was investigated. Disc diffusion test was used to study the antimicrobial resistance of isolates collected from county hospitals and a teaching hospital. The, data was analyzed by WHONET5 and SPSS statistic software. A total of 655 strains and 1682 strains were collected from county hospitals and a teaching hospital, respectively, in the year of 2003. The top ten pathogens were Coagulase negative staphylococci (CNS), E. coli, Klebsiella spp., S. areus, P. aeruginosa, Enterococcus spp., Enterobacter spp., otherwise Salmonella spp., Proteus spp., Shigella spp. in county hospitals and Streptococcus spp., Acinetobacter spp., X. maltophilia in the teaching hospital. The prevalence of multi-drug resistant bacteria was 5% (4/86) of methicillin-resistant S. areus (MRSA), 12% (16/133) and 15.8% (9/57) of extended-spectrum β-lactamases producing strains of E. coli and Klebsiella spp., respectively, in county hospitals. All of the three rates were lower than that in the teaching hospital and the difference was statistically significant (P<0.01). However, the incidence of methicillin-resistant CNS (MRCNS) reached to 70% (109/156) in the two classes of hospitals. Generally, the antimicrobial resistant rates in the county hospitals were lower than those in the teaching hospital, except the resistant rates of ciprofloxacin, erythromycin, clindamycin, SMZco which were similar in the two classes of hospitals. There were differences between county hospitals and the teaching hospital in the distribution of clinical isolates and prevalence of antimicrobial resistance. It was the basis of rational use of antimicrobial agents to monitor antimicrobial resistance by each hospital.
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References
Ma Y, Li J Y, Jin S J. The enhancement of antimicrobial resistance surveillance. Natl Med J China, 2003, 83: 1029–1030
National Committee for Clinical Laboratory Standards. Performance standards for antimicrobial susceptibility testing. 11th inform suppl. M2-M7 and M7-M5. National Committee for Clinical Laboratory Standards, Wayne, PA, 2001.
Fridkin S K, Welbel S F, Weinstein R A. Magnitude and prevention of nosocomial infections in the intensive care unit. Infect Dis Clin North Am, 1997, 11: 479–496
Shen Z Y, Sun Z Y, Wang H B. A surveillance study on bacterial resistance in Wuhan district. Chin J Intern Med, 1998, 37(7): 440–443
Shen Z Y, Sun Z Y, Wang H B. A surveillance study on antimicrobial resistance of chinical isolates in Hubei area, 2000. Chin Prev Med, 2001, 2(3): 185–187
Fridkin S K, Hill H A, Volkva N Vet al. Temporal changes in prevalence of antimicrobial resistance in 23 U. S. hospitals. Emerging Infectious Diseases, 2002, 8(7): 697–701
Domenech-Sanchez A, Suarez A I. Activity of nine antimicrobial agents against clinical isolates of Escherichia coli producing extended-spectrum β-lactamases and deficient or not in porins. J Antimicrob Chemother, 2000, 46: 858–860
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SUN Ziyong, female, born in 1963, Associate Professor
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Ziyong, S., Li, L., Xuhui, Z. et al. Analysis on antimicrobial resistance of clinical bacteria isolated from county hospitals and a teaching hospital. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 26, 386–388 (2006). https://doi.org/10.1007/BF02829585
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DOI: https://doi.org/10.1007/BF02829585