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Role of prostaglandin E2 on gastric ulcers induced by non-steroidal anti-inflammatory compounds (NOSAC)

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Summary

We investigated the effect of indomethacin and aspirin on the prostaglandin E2 (PGE2) levels in rat gastric mucosa. In untreated controls, the PGE2 level was 1085 ± 80 ng/g in the fundic- and 2435 ± 339 ng/g in the antral mucosa; it was markedly reduced by indomethacin (6 or 20mg/kg) in a dose-related manner prior to the formation of gastric ulcers. Aspirin (200mg/kg) also decreased the mucosal PGE2 content. The simultaneous infusion of 5Μg/kg 16, 16-dimethyl PGE2 and 20 mg/kg indomethacin inhibited the formation of gastric ulcers. Our experimental results suggested that the indomethacin- or aspirin-induced gastric mucosal lesions are due to a deficiency of endogenous mucosal PGE2.

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Authors and Affiliations

  1. The Third Department of Internal Medicine, Osaka City University Medical School, 1-5-7 Asahi-machi, Abeno-ku, 545, Osaka, Japan

    Kenzo Kobayashi M.D., Tetsuo Arakawa M.D., Hajime Nakamura M.D., Shinji Chono M.D., Hiroaki Yamada M.D., Teisuke Kamata M.D. & Tokio Ono M.D.

Authors
  1. Kenzo Kobayashi M.D.
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  2. Tetsuo Arakawa M.D.
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  3. Hajime Nakamura M.D.
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  4. Shinji Chono M.D.
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  5. Hiroaki Yamada M.D.
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  6. Teisuke Kamata M.D.
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  7. Tokio Ono M.D.
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Kobayashi, K., Arakawa, T., Nakamura, H. et al. Role of prostaglandin E2 on gastric ulcers induced by non-steroidal anti-inflammatory compounds (NOSAC). Gastroenterol Jpn 16, 600–603 (1981). https://doi.org/10.1007/BF02813795

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  • DOI: https://doi.org/10.1007/BF02813795

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