Abstract
Parthenolide (PTL) is a sesquiterpene lactone that occurs naturally. It demonstrates a variety of beneficial effects, such as antioxidant, anti-inflammatory, and antiapoptotic properties. The study investigated the potential protective impact of PTL on indomethacin (INDO) induced stomach ulcers in rats. The rats were classified into 5 distinct categories. Group 1 served as the “control” group. Rats in the second group received a single oral dosage of INDO (50 mg kg−1). Rats in Groups three and four received 20 and 40 mg kg−1 oral PTL 1 h before INDO. Omeprazole (30 mg kg−1) was given orally to Group 5 rats 1 h before INDO. Pretreatment with PTL increased stomach pH and decreased gastric volume as well as reduced the morphological and histological changes induced by INDO. Analysis of probable pathways showed that pre-treatment with PTL successfully reduced oxidative, inflammatory, and apoptotic consequences caused by INDO. The ingestion of PTL leads to a notable increase in the levels of glutathione reduced (GSH) and the activities of superoxide dismutase (SOD) and catalase (CAT). Furthermore, PTL decreased the concentration of malondialdehyde (MDA). In contrast, it was shown that PTL increased both cyclooxygenase-1 (COX-1) and prostaglandin E2 (PGE2). PTL shows a significant decrease in the expression of interleukin-1 beta (IL-1β), tumor necrosis factor-alpha (TNF-α), inducible nitric oxide synthase (iNOS), and nuclear factor kappa B (NF-κB). PTL therapy resulted in a decrease in Bcl-2-associated X protein (Bax) levels and an increase in B-cell lymphoma 2 (Bcl2) levels. In conclusion, PTL offers gastroprotection by its antioxidant, anti-inflammatory, and anti-apoptotic qualities.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Data availability
No datasets were generated or analysed during the current study.
References
Abdelkader Saidi S, Al-Shaikh TM, Hamden K (2023) Evaluation of gastroprotective effect of Betalain-rich ethanol extract from Opuntia stricta var. Dillenii employing an in vivo rat model. J Food Qual 2023:2215454. https://doi.org/10.1155/2023/2215454
Adhikary B, Yadav SK, Roy K, Bandyopadhyay SK, Chattopadhyay S (2011) Black tea and theaflavins assist healing of indomethacin-induced gastric ulceration in mice by antioxidative action. Evidence-Based Complement Altern Med 2011:1–11. https://doi.org/10.1155/2011/546560
Ahmed MAE, Mohanad M, Ahmed AAE, Aboulhoda BE, El-Awdan SA (2021) Mechanistic insights into the protective effects of chlorogenic acid against indomethacin-induced gastric ulcer in rats: modulation of the cross talk between autophagy and apoptosis signaling. Life Sci 275:119370. https://doi.org/10.1016/j.lfs.2021.119370
Albalawi RS, Binmahfouz LS, Hareeri RH, Shaik RA, Bagher AM (2023) Parthenolide phytosomes attenuated gentamicin-induced nephrotoxicity in rats via activation of Sirt-1, Nrf2, OH-1, and NQO1 axis. Molecules 28:2741. https://doi.org/10.3390/molecules28062741
Aleid IS, Alfheeaid HA, Aljutaily T, Alhomaid RM, Alharbi HF, Althwab SA, Abdel-Rahman HA, Algeffari MA, Barakat H (2021) Gastroprotective effects of spirulina platensis, golden kiwifruit flesh, and golden kiwifruit peel extracts individually or in combination against indomethacin-induced gastric ulcer in rats. Nutrients 13:3499. https://doi.org/10.3390/nu13103499
AlKreathy HM, Alghamdi MK, Esmat A (2020) Tetramethylpyrazine ameliorates indomethacin-induced gastric ulcer in rats: impact on oxidative, inflammatory, and angiogenic machineries. Saudi Pharm J 28:916–926. https://doi.org/10.1016/j.jsps.2020.06.012
Alp Yildirim FI, Uyanik Ö, Özyoğurtçu H, Gürel A, Atukeren P, Gümüştaş K, Özdemir O, Uydeş-Doğan S (2015) Aggravating effect of atorvastatin on indomethacin-induced gastric injury: focus on PGE2, TNF-α, neutrophils and iNOS. Prostaglandins Other Lipid Mediat 121:53–62. https://doi.org/10.1016/j.prostaglandins.2015.07.002
Araki H, Komoike Y, Matsumoto M, Tanaka A, Takeuchi K (2002) Healing of duodenal ulcers is not impaired by indomethacin or rofecoxib, the selective COX-2 inhibitor, in Rats. Digestion 66:145–153. https://doi.org/10.1159/000066759
Barboza KRM, Coco LZ, Alves GM, Peters B, Vasquez EC, Pereira TMC, Meyrelles SS, Campagnaro BP (2018) Gastroprotective effect of oral kefir on indomethacin-induced acute gastric lesions in mice: impact on oxidative stress. Life Sci 209:370–376. https://doi.org/10.1016/j.lfs.2018.08.035
Benvenutti RC, Dalla Vecchia CA, Locateli G, Serpa PZ, Lutinski JA, Rodrigues Junior SA, Corralo V, Gutiérrez MV, Vilegas W, Somensi LB, Longo B, Knihs JF, Mota da Silva L, de Andrade SF, Roman Junior WA (2020) Gastroprotective activity of hydroalcoholic extract of the leaves of Urera baccifera in rodents. J Ethnopharmacol 250:112473. https://doi.org/10.1016/j.jep.2019.112473
Bi WP, Man HB, Man MQ (2014) Efficacy and safety of herbal medicines in treating gastric ulcer: a review. World J Gastroenterol. https://doi.org/10.3748/wjg.v20.i45.17020
Boushra AF, Elsayed AM, Ibrahim NA, Abdelwahed MK, Ahmed EI (2019) A comparative study on the possible protective effect of esomeprazole, spirulina, wheatgrass on indomethacin-induced gastric ulcer in male albino rats. Mol Biol Rep 46:4843–4860. https://doi.org/10.1007/s11033-019-04933-1
Boyacioglu M, Kum C, Sekkin S, Yalinkilinc HS, Avci H, Epikmen ET, Karademir U (2016) The effects of lycopene on DNA damage and oxidative stress on indomethacin-induced gastric ulcer in rats. Clin Nutr 35:428–435. https://doi.org/10.1016/j.clnu.2015.03.006
Chen N, Wei F, Wang L, Cui S, Wan Y, Liu S (2016a) Tumor necrosis factor alpha induces neural stem cell apoptosis through activating p38 MAPK pathway. Neurochem Res 41:3052–3062. https://doi.org/10.1007/s11064-016-2024-8
Chen X-Y, Chen H-M, Liu Y-H, Zhang Z-B, Zheng Y-F, Su Z-Q, Zhang X, Xie J-H, Liang Y-Z, Fu L-D, Lai X-P, Su Z-R, Huang X-Q (2016b) The gastroprotective effect of pogostone from Pogostemonis Herba against indomethacin-induced gastric ulcer in rats. Exp Biol Med 241:193–204. https://doi.org/10.1177/1535370215600099
Chen X, Liu R, Liu X, Xu C, Wang X (2018) L-ascorbic acid-2-glucoside inhibits Helicobacter pylori-induced apoptosis through mitochondrial pathway in gastric epithelial cells. Biomed Pharmacother 97:75–81. https://doi.org/10.1016/j.biopha.2017.10.030
Correia C, Lee S-H, Meng XW, Vincelette ND, Knorr KLB, Ding H, Nowakowski GS, Dai H, Kaufmann SH (2015) Emerging understanding of Bcl-2 biology: implications for neoplastic progression and treatment Biochimica et Biophysica Acta (BBA). Mol Cell Res 1853:1658–1671. https://doi.org/10.1016/j.bbamcr.2015.03.012
Danisman B, Cicek B, Yildirim S, Bolat I, Kantar D, Golokhvast KS, Nikitovic D, Tsatsakis A, Taghizadehghalehjoughi A (2023) Carnosic acid ameliorates indomethacin-induced gastric ulceration in rats by alleviating oxidative stress and inflammation. Biomedicines 11:829. https://doi.org/10.3390/biomedicines11030829
Drini M (2017) Peptic ulcer disease and non-steroidal anti-inflammatory drugs. Aust Prescr 40:91–93. https://doi.org/10.18773/austprescr.2017.037
El-Ashmawy NE, Khedr EG, El-Bahrawy HA, Selim HM (2016) Gastroprotective effect of garlic in indomethacin induced gastric ulcer in rats. Nutrition 32:849–854. https://doi.org/10.1016/j.nut.2016.01.010
El-Ashmawy NE, Khedr EG, El-Bahrawy HA, Selim HM (2016) Nebivolol prevents indomethacin-induced gastric ulcer in rats. J Immunotoxicol 13:580–589. https://doi.org/10.3109/1547691X.2016.1142488
Eraslan E, Tanyeli A, Güler MC, Kurt N, Yetim Z (2020) Agomelatine prevents indomethacin-induced gastric ulcer in rats. Pharmacol Rep 72:984–991. https://doi.org/10.1007/s43440-019-00049-2
Ermis A, Aritici Colak G, Acikel-Elmas M, Arbak S, Kolgazi M (2023) Ferulic acid treats gastric ulcer via suppressing oxidative stress and inflammation. Life 13:388. https://doi.org/10.3390/life13020388
Fiebich BL, Lieb K, Engels S, Heinrich M (2002) Inhibition of LPS-induced p42/44 MAP kinase activation and iNOS/NO synthesis by parthenolide in rat primary microglial cells. J Neuroimmunol 132:18–24. https://doi.org/10.1016/S0165-5728(02)00279-5
Fleury C, Mignotte B, Vayssière J-L (2002) Mitochondrial reactive oxygen species in cell death signaling. Biochimie 84:131–141. https://doi.org/10.1016/S0300-9084(02)01369-X
Freund RRA, Gobrecht P, Fischer D, Arndt HD (2020) Advances in chemistry and bioactivity of parthenolide. Nat Prod Rep. https://doi.org/10.1039/c9np00049f
Gebril SM, Ito Y, Abu-Dief EE, Hussein MRA, Elsayed HM, Mohammad AN, Abdelaal UM, Higuchi K (2020) Ultra-structural study of the indomethacin-induced apoptosis and autophagy in rat gastric parietal cells. Ultrastruct Pathol 44:300–313. https://doi.org/10.1080/01913123.2020.1772429
Grimm S, Bauer MK, Baeuerle PA, Schulze-Osthoff K (1996) Bcl-2 down-regulates the activity of transcription factor NF-kappaB induced upon apoptosis. J Cell Biol 134:13–23. https://doi.org/10.1083/jcb.134.1.13
Guzmán-Gómez O, García-Rodríguez RV, Pérez-Gutierrez S, Rivero-Ramírez NL, García-Martínez Y, Pablo-Pérez SS, Pérez-Pastén-Borja R, Cristóbal-Luna JM, Chamorro-Cevallos G (2023) Protective effect of the phycobiliproteins from Arthrospira maxima on indomethacin-induced gastric ulcer in a rat model. Plants 12:1586. https://doi.org/10.3390/plants12081586
Hammady M (2024) Application of immunohistochemistry in rat models of erosive gastritis. Egypt J Veterin Sci 55:1021–1036
Harakeh S, Saber SH, Akefe IO, Shaker S, Barkaat Hussain M, Saad Almasaudi A, Saleh SMM, Almasaudi S (2022) Saudi honey alleviates indomethacin-induced gastric ulcer via improving antioxidant and anti-inflammatory responses in male albino rats. Saudi J Biol Sci 29:3040–3050. https://doi.org/10.1016/j.sjbs.2022.01.031
Heeba GH, Hassan MKA, Amin RS (2009) Gastroprotective effect of simvastatin against indomethacin-induced gastric ulcer in rats: role of nitric oxide and prostaglandins. Eur J Pharmacol 607:188–193. https://doi.org/10.1016/j.ejphar.2009.02.008
Ito H, Matsui H, Hirayama A, Indo HP, Majima HJ, Hyodo I (2016) Reactive oxygen species induced by nonsteroidal antiinflammatory drugs enhance the effects of photodynamic therapy in gastric cancer cells. J Clin Biochem Nutr 58:180–185. https://doi.org/10.3164/jcbn.155124
Jafari A, Andishfar N, Esmaeilzadeh Z, Khezri MR, Ghasemnejad-Berenji M (2022) Gastroprotective effect of topiramate on indomethacin-induced peptic ulcer in rats: biochemical and histological analyses. Basic Clin Pharmacol Toxicol 130:559–568. https://doi.org/10.1111/bcpt.13718
Kim CY, Kang B, Hong J, Choi HS (2020) Parthenolide inhibits lipid accumulation via activation of Nrf2/Keap1 signaling during adipocyte differentiation. Food Sci Biotechnol 29:431–440. https://doi.org/10.1007/s10068-019-00672-y
Kim YS, Lee JH, Song J, Kim H (2020) Gastroprotective effects of inulae flos on hcl/ethanol-induced gastric ulcers in rats. Molecules 25:1586. https://doi.org/10.3390/molecules25235623
Küçükler S, Kandemir FM, Yıldırım S (2022) Protective effect of chrysin on indomethacin induced gastric ulcer in rats: role of multi-pathway regulation. Biotechnic Histochem 97:490–503. https://doi.org/10.1080/10520295.2021.2014569
Liu Q, Zhao J, Tan R, Zhou H, Lin Z, Zheng M, Romas E, Xu J, Sims N (2015a) Parthenolide inhibits pro-inflammatory cytokine production and exhibits protective effects on progression of collagen-induced arthritis in a rat model. Scand J Rheumatol 44:182–191. https://doi.org/10.3109/03009742.2014.938113
Liu Y-H, Zhang Z-B, Zheng Y-F, Chen H-M, Yu X-T, Chen X-Y, Zhang X, Xie J-H, Su Z-Q, Feng X-X, Zeng H-F, Su Z-R (2015b) Gastroprotective effect of andrographolide sodium bisulfite against indomethacin-induced gastric ulceration in rats. Int Immunopharmacol 26:384–391. https://doi.org/10.1016/j.intimp.2015.04.025
Liu W, Shang P, Liu T, Xu H, Ren D, Zhou W, Wen A, Ding Y (2017) Gastroprotective effects of chebulagic acid against ethanol-induced gastric injury in rats. Chem Biol Interact 278:1–8. https://doi.org/10.1016/j.cbi.2017.09.019
Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCT method. Methods 25:402–408. https://doi.org/10.1006/meth.2001.1262
Luo C, Chen H, Wang Y, Lin G, Li C, Tan L, Su Z, Lai X, Xie J, Zeng H (2018) Protective effect of coptisine free base on indomethacin-induced gastric ulcers in rats: characterization of potential molecular mechanisms. Life Sci 193:47–56. https://doi.org/10.1016/j.lfs.2017.12.004
Ma N, Sun Y, Yi J, Zhou L, Cai S (2022) Chinese sumac (Rhus chinensis Mill.) fruits alleviate indomethacin-induced gastric ulcer in mice by improving oxidative stress, inflammation and apoptosis. J Ethnopharmacol 284:114752. https://doi.org/10.1016/j.jep.2021.114752
Mahmoud MF, Nabil M, Abdo W, Abdelfattah MAO, El-Shazly AM, El Kharrassi Y, Sobeh M (2021) Syzygium samarangense leaf extract mitigates indomethacin-induced gastropathy via the NF-κB signaling pathway in rats. Biomed Pharmacother 139:111675. https://doi.org/10.1016/j.biopha.2021.111675
Mahmoud MF, Nabil M, Hasan RA, El-Shazly AM, El-Ansari MA, Sobeh M (2022) Pentagalloyl glucose, a major compound in mango seed kernel, exhibits distinct gastroprotective effects in indomethacin-induced gastropathy in rats via modulating the NO/eNOS/iNOS signaling pathway. Front Pharmacol 13:800986. https://doi.org/10.3389/fphar.2022.800986
Mahmoud MF, Abdo W, Nabil M, Drissi B, El-Shazly AM, Abdelfattah MAO, Sobeh M (2023) Apple (Malus domestica Borkh) leaves attenuate indomethacin-induced gastric ulcer in rats. Biomed Pharmacother 160:114331. https://doi.org/10.1016/j.biopha.2023.114331
Mao W, Zhu Z (2018) Parthenolide inhibits hydrogen peroxide-induced osteoblast apoptosis. Mol Med Rep. https://doi.org/10.3892/mmr.2018.8908
Mard SA, Pipelzadeh MH, Teimoori A, Neisi N, Mojahedin S, Khani MZS, Ahmadi I (2016) Protective activity of crocin against indomethacin-induced gastric lesions in rats. J Nat Med 70:62–74. https://doi.org/10.1007/s11418-015-0938-0
Musumba C, Prichard DM, Pirmohamed M (2009) Review article: cellular and molecular mechanisms of NSAID-induced peptic ulcers. Aliment Pharmacol Ther 30:517–531. https://doi.org/10.1111/j.1365-2036.2009.04086.x
Nabil M, El Raey MA, Abdo W, Abdelfattah MAO, El-Shazly AM, Sobeh M, Mahmoud MF (2021) Gastro-protective effects of Albizia anthelmintica leaf extract on indomethacin-induced gastric ulcer in Wistar rats: in silico and in vivo studies. Antioxidants 10:176. https://doi.org/10.3390/antiox10020176
Naito Y, Yoshikawa T (2006) Oxidative stress involvement and gene expression in indomethacin-induced gastropathy. Redox Rep 11:243–253. https://doi.org/10.1179/135100006X155021
Nathan C (1997) Inducible nitric oxide synthase: what difference does it make? J Clin Invest. https://doi.org/10.1172/JCI119782
Oluwabunmi I, Abiola T (2015) Gastroprotective effect of methanolic extract of Gomphrena celosioides on indomethacin induced gastric ulcer in Wistar albino rats. Int J Appl Basic Med Res 5:41. https://doi.org/10.4103/2229-516X.149238
Pareek A, Suthar M, Rathore GS, Bansal V (2011) Feverfew (Tanacetum parthenium L.): a systematic review. In: Pharmacognosy reviews, vol. 5, issue 9. pp 103–110. https://doi.org/10.4103/0973-7847.79105
Saadane A, Masters S, DiDonato J, Li J, Berger M (2007) Parthenolide inhibits IκB kinase, NF-κB activation, and inflammatory response in cystic fibrosis cells and mice. Am J Respir Cell Mol Biol 36:728–736. https://doi.org/10.1165/rcmb.2006-0323OC
Sabiu S, Garuba T, Sunmonu T, Ajani E, Sulyman A, Nurain I, Balogun A (2015) Indomethacin-induced gastric ulceration in rats: protective roles of Spondias mombin and Ficus exasperata. Toxicol Rep 2:261–267. https://doi.org/10.1016/j.toxrep.2015.01.002
Sabiu S, Garuba T, Sunmonu TO, Sulyman AO, Ismail NO (2016) Indomethacin-induced gastric ulceration in rats: ameliorative roles of Spondias mombin and Ficus exasperata. Pharm Biol 54:180–186. https://doi.org/10.3109/13880209.2015.1029050
Salem NA, Wahba MA, Eisa WH, El-Shamarka M, Khalil W (2018) Silver oxide nanoparticles alleviate indomethacin-induced gastric injury: a novel antiulcer agent. Inflammopharmacology 26:1025–1035. https://doi.org/10.1007/s10787-017-0424-2
Santucci L, Fiorucci S, Di Matteo FM, Morelli A (1995) Role of tumor necrosis factor α release and leukocyte margination in indomethacin-induced gastric injury in rats. Gastroenterology 108:393–401. https://doi.org/10.1016/0016-5085(95)90065-9
Sathish R, Vyawahare B, Natarajan K (2011) Antiulcerogenic activity of Lantana camara leaves on gastric and duodenal ulcers in experimental rats. J Ethnopharmacol 134:195–197. https://doi.org/10.1016/j.jep.2010.11.049
Sayed Abdel-Tawab M, Mostafa Tork O, Mostafa-Hedeab G, Ewaiss Hassan M (2020) Protective effects of quercetin and melatonin on indomethacin induced gastric ulcers in rats. Rep Biochem Mol Biol 9:278–290. https://doi.org/10.29252/rbmb.9.3.278
Schacht V, Kern JS (2015) Basics of immunohistochemistry. J Invest Dermatol 135:1–4. https://doi.org/10.1038/jid.2014.541
Schubert ML (2017) Physiologic, pathophysiologic, and pharmacologic regulation of gastric acid secretion. Curr Opin Gastroenterol 33:430–438. https://doi.org/10.1097/MOG.0000000000000392
Shaik RA, Eid BG (2022) Piceatannol affects gastric ulcers induced by indomethacin: association of antioxidant, anti-inflammatory, and angiogenesis mechanisms in rats. Life 12:356. https://doi.org/10.3390/life12030356
Sheehan M, Wong HR, Hake PW, Malhotra V, O’Connor M, Zingarelli B (2002) Parthenolide, an inhibitor of the nuclear factor-κB pathway, ameliorates cardiovascular derangement and outcome in endotoxic shock in rodents. Mol Pharmacol 61:953–963. https://doi.org/10.1124/mol.61.5.953
Shoaib M, Shah I, Ali N, Adhikari A, Tahir MN, Shah SWA, Ishtiaq S, Khan J, Khan S, Umer MN (2017) Sesquiterpene lactone! a promising antioxidant, anticancer and moderate antinociceptive agent from Artemisia macrocephala jacquem. BMC Complement Altern Med 17:27. https://doi.org/10.1186/s12906-016-1517-y
Slomiany BL, Piotrowski J, Slomiany A (1997) Induction of tumor necrosis factor-α and apoptosis in gastric mucosal injury by indomethacin: effect of omeprazole and ebrotidine. Scand J Gastroenterol 32:638–642. https://doi.org/10.3109/00365529708996511
Suleyman H, Albayrak A, Bilici M, Cadirci E, Halici Z (2010) Different mechanisms in formation and prevention of indomethacin-induced gastric ulcers. Inflammation 33:224–234. https://doi.org/10.1007/s10753-009-9176-5
Takeuchi K (2012) Pathogenesis of NSAID-induced gastric damage: importance of cyclooxygenase inhibition and gastric hypermotility. World J Gastroenterol 18:2147. https://doi.org/10.3748/wjg.v18.i18.2147
Takeuchi T, Miura S, Wang L, Uehara K, Mizumori M, Kishikawa H, Hokari R, Higuchi H, Adachi M, Nakamizo H, Ishii H (2002) Nuclear factor-kappaB and TNF-alpha mediate gastric ulceration induced by phorbol myristate acetate. Dig Dis Sci 47:2070–8. https://doi.org/10.1023/a:1019633114854
Tamaddonfard E, Erfanparast A, Farshid AA, Imani M, Mirzakhani N, Salighedar R, Tamaddonfard S (2019) Safranal, a constituent of saffron, exerts gastro-protective effects against indomethacin-induced gastric ulcer. Life Sci 224:88–94. https://doi.org/10.1016/j.lfs.2019.03.054
Tomisato W, Tsutsumi S, Rokutan K, Tsuchiya T, Mizushima T (2001) NSAIDs induce both necrosis and apoptosis in guinea pig gastric mucosal cells in primary culture. Am J Physiol Gastrointest Liver Physiol 281:G1092-100. https://doi.org/10.1152/ajpgi.2001.281.4.G1092
Tournier H, Schinella G, De Balsa EM, Buschiazzo H, Mañez S, De Buschiazzo PM (2010) Effect of the chloroform extract of Tanacetum vulgare and one of its active principles, parthenolide, on experimental gastric ulcer in rats. J Pharm Pharmacol 51:215–219. https://doi.org/10.1211/0022357991772169
Tsikas D (2017) Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: analytical and biological challenges. Anal Biochem 524:13–30. https://doi.org/10.1016/j.ab.2016.10.021
Ugan RA, Un H (2020) The protective roles of butein on indomethacin induced gastric ulcer in mice. Eurasian J Med 52:265–270. https://doi.org/10.5152/eurasianjmed.2020.20022
Vaananen PM, Meddings JB, Wallace JL (1991) Role of oxygen-derived free radicals in indomethacin-induced gastric injury. Am J of Physiol-Gastrointest Liver Physiol 261:G470–G475. https://doi.org/10.1152/ajpgi.1991.261.3.G470
Wang T, Zhao S, Wang Y, Yang Y, Yao L, Chu L, Du H, Fu F (2014) Protective effects of escin against indomethacin-induced gastric ulcer in mice. Toxicol Mech Methods 24:560–566. https://doi.org/10.3109/15376516.2014.951815
Wang J, Tong M, Zhao B, Zhu G, Xi D, Yang J (2020) Parthenolide ameliorates intracerebral hemorrhage-induced brain injury in rats. Phytother Res 34:153–160. https://doi.org/10.1002/ptr.6510
Xavier S, Magalhães J, Cotter J (2018) Proton pump inhibitors: are they a real threat to the patient? GE Port J Gastroenterol 25:243–252. https://doi.org/10.1159/000487154
Xie C, Liu L, Zhu S, Wei M (2021) Effectiveness and safety of Chinese medicine combined with omeprazole in the treatment of gastric ulcer: a protocol for systematic review and meta-analysis. Medicine (United States) 100:E25744. https://doi.org/10.1097/MD.0000000000025744
Yao H, Tang X, Shao X, Feng L, Wu N, Yao K (2007) Parthenolide protects human lens epithelial cells from oxidative stress-induced apoptosis via inhibition of activation of caspase-3 and caspase-9. Cell Res 17:565–571. https://doi.org/10.1038/cr.2007.6
Zaghlool SS, Abo-Seif AA, Rabeh MA, Abdelmohsen UR, Messiha BAS (2019) Gastro-protective and antioxidant potential of Althaea officinalis and Solanum nigrum on pyloric ligation/indomethacin-induced ulceration in rats. Antioxidants 8:512. https://doi.org/10.3390/antiox8110512
Zhang S, Ong C-N, Shen H-M (2004) Involvement of proapoptotic Bcl-2 family members in parthenolide-induced mitochondrial dysfunction and apoptosis. Cancer Lett 211:175–188. https://doi.org/10.1016/j.canlet.2004.03.033
Zhang Y, Huang Q, Chen Y, Peng X, Wang Y, Li S, Wu J, Luo C, Gong W, Yin B, Xiao J, Zhou W, Peng F, Long H (2020) Parthenolide, an NF-κB inhibitor, alleviates peritoneal fibrosis by suppressing the TGF-β/Smad pathway. Int Immunopharmacol 78:106064. https://doi.org/10.1016/j.intimp.2019.106064
Zhou D, Yang Q, Tian T, Chang Y, Li Y, Duan LR, Li H, Wang SW (2020) Gastroprotective effect of gallic acid against ethanol-induced gastric ulcer in rats: involvement of the Nrf2/HO-1 signaling and anti-apoptosis role. Biomed Pharmacother 126:110075. https://doi.org/10.1016/j.biopha.2020.110075
Zhu S, Sun P, Bennett S, Charlesworth O, Tan R, Peng X, Gu Q, Kujan O, Xu J (2023) The therapeutic effect and mechanism of parthenolide in skeletal disease, cancers, and cytokine storm. Front Pharmacol 14:1111218. https://doi.org/10.3389/fphar.2023.1111218
Acknowledgements
The authors gratefully acknowledge the technical and financial support provided by the Ministry of Education and King Abdulaziz University, DSR, Jeddah, Saudi Arabia.
Funding
This research work was funded by the Institutional Fund Projects under grant no. (IFPIP:1356-166-1443).
Author information
Authors and Affiliations
Contributions
Author reviewed the manuscript. The author declares that all data were generated in-house and that no paper mill was used.
Corresponding author
Ethics declarations
Ethics approval
The study was conducted by the Declaration of Helsinki, and approved by the Institutional Ethics Committee of FOP, KAU (Ref no - PH-1444-40).
Competing interests
The authors declare no competing interests.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Shaik, R.A. Parthenolide alleviates indomethacin-induced gastric ulcer in rats via antioxidant, anti-inflammatory, and antiapoptotic activities. Naunyn-Schmiedeberg's Arch Pharmacol (2024). https://doi.org/10.1007/s00210-024-03110-x
Received:
Accepted:
Published:
DOI: https://doi.org/10.1007/s00210-024-03110-x