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Stimulation of mucus and nonparietal cell secretion by the E2 prostaglandins

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Abstract

The effects of prostaglandin E2 (PGE2), 15-methyl prostaglandin E2 (15M), and 16,16-dimethyl prostaglandin E2 (16DM) on gastric mucus and nonparietal cell secretion in rats were measured. Alcian blue binding was used as a measure of gastric mucus. Applied topically, all three agents stimulated nonparietal cell secretion, and PGE2 and 16 DM stimulated the secretion of mucus, increasing the fraction in the gastric contents but not that adherent to the mucosa. Topical 15M did not stimulate the production of mucus. Given intravenously, all three agents increased the amount of mucus in the gastric contents without altering the amount of mucus bound to the mucosa. The prostaglandins had no effect on nonparietal cell secretion when given intravenously. These effects could be relevant to the ability of the E2 prostaglandins to protect the gastric mucosa from damage.

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Authors and Affiliations

  1. Department of Surgey, Faculty of Medicine, University of British Columbia, 700 West 10 Avenue, V5Z 1L5, Vancouver, British Columbia, Canada

    John P. Bolton MA, MSc, MB, FRCS, Douglas Palmer MSc &  Max M. Cohen MB, FRCS (E, C)

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  1. John P. Bolton MA, MSc, MB, FRCS
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  2. Douglas Palmer MSc
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  3. Max M. Cohen MB, FRCS (E, C)
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Support by: grant MA-5316 from the Medical Research Council, and the Upjohn Company

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Bolton, J.P., Palmer, D. & Cohen, M.M. Stimulation of mucus and nonparietal cell secretion by the E2 prostaglandins. Digest Dis Sci 23, 359–364 (1978). https://doi.org/10.1007/BF01072421

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  • DOI: https://doi.org/10.1007/BF01072421

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