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Different bioavailability in humans of wheat and fish selenium as measured by blood platelet response to increased dietary Se

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Abstract

The bioavailabilities of selenium (Se) from Se-rich fish species and Se-rich wheat were compared in a study involving 32 healthy volunteers. Initial serum Se values were 109±16 μg/L (mean±SD). For 6 wk, one group (n=11) included Se-rich bread in their diet, bringing daily average intake of Se up to 135±25 μg/d. Another group (n=11) consumed Se-rich fish daily (average Se intake: 115±31 μg/d), whereas the control group (n=10) ate their normal diet, providing 77±25 μg Se/d. Serum Se increased by 17% (P<0.01), and platelet Se increased by 30% (P<0.01) in the wheat group. Although platelet Se decreased by 11% in the fish group, no changes in serum and platelet Se in the fish or control group reached statistical significance. Glutathione peroxidase (EC 1.11.1.9; GSH-Px) activity in serum and platelets did not change during the study, nor did platelet mercury (Hg) content. Since the dietary intake of Hg, arsenium (As), and fatty acids could not satisfactorily explain the lack of response in the fish group, the results are indicative of low bioavailability of fish Se in humans. At present, wheat Se seems to be the most important factor contributing to the body stores of Se in this study population.

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References

  1. M. F. Robinson, H. M. Rea, G. M. Friend, R. H. D. Steward, P. C. Snow, and C. D. Thomson,Br. J. Nutr. 39, 589–600 (1978).

    Article  PubMed  CAS  Google Scholar 

  2. G. N. Schrauzer and D. A. White,Bioorg. Chem. 8, 303–318 (1978).

    CAS  Google Scholar 

  3. O. A. Levander, G. Alfthan, H. Arvilommi, J. K. Huttunen, M. Kataja, P. Koivistoinen, and J. Pikkarainen,Am. J. Clin. Nutr. 37, 887–897 (1983).

    PubMed  CAS  Google Scholar 

  4. C. D. Thomson, L. K. Ong, and M. F. Robinson,Am. J. Clin. Nutr. 41, 1015–1022 (1985).

    PubMed  CAS  Google Scholar 

  5. X. Luo, H. Wei, C. Yang, J. Xing, X. Liu, C. Qiao, Y. Feng, J. Liu, Y. Liu, Q. Wu, X. Liu, J. Guo, B. Stoecker, J. Spallholz, and S. P. Yang,Am. J. Clin. Nutr. 42, 439–448 (1985).

    PubMed  CAS  Google Scholar 

  6. G. Yang, S. Yin, R. Zhou, L. Gu, B. Yan, Y. Liu, and Y. Liu,J. Trace Elem. Electrol. Health Dis. 3, 123–130 (1989).

    CAS  Google Scholar 

  7. J. Clausen and S. A. Nielsen,Biol. Trace Element Res. 15, 125–138 (1988).

    CAS  Google Scholar 

  8. H. M. Meltzer, G. Norheim, K. Bibow, K. Myhre, and H. Holm,Europ. J. Clin. Nutr. 44, 435–446 (1990).

    CAS  Google Scholar 

  9. D. J. Pearson, J. P. Day, V. J. Suarez-Mendez, P. F. Miller, S. Owen, and A. Woodcock,Europ. J. Clin. Nutr. 44, 277–283 (1990).

    CAS  Google Scholar 

  10. J. Ringstad, B. K. Jacobsen, and Y. Thomassen,J. Trace. Elem. Electrolytes Health Dis. 1, 27–31 (1987).

    PubMed  CAS  Google Scholar 

  11. C. A. Swanson, M. P. Longnecker, C. Veillon, S. M. Howe, O. A. Levander, P. R. Taylor, P. A. McAdam, C. Brown, M. J. Stampfer, and W. C. Willett,Am. J. Clin. Nutr. 52, 858–862 (1990).

    PubMed  CAS  Google Scholar 

  12. G. Yang, S. Wang, R. Zhou, and S. Sun,Am. J. Clin. Nutr. 37, 872–881 (1983).

    PubMed  CAS  Google Scholar 

  13. R. F. Burk,J. Nutr. 116, 1584–1586 (1986).

    PubMed  CAS  Google Scholar 

  14. L. Magos and M. Webb,Critical Rev. Tox. 8, 1–43 (1980).

    Article  CAS  Google Scholar 

  15. A. T. Diplock, W. J. Watkins, and M. Hewison,Ann. Clin. Res. 18, 55–60 (1986).

    PubMed  CAS  Google Scholar 

  16. A. Naganuma, T. Tanaka, K. Maeda, R. Matsuda, J. Tabata-Hanyu, and N. Imura,Toxicology 29, 77–86 (1983).

    Article  PubMed  CAS  Google Scholar 

  17. G. N. Schrauzer,J. Univ. Occupational Environmental Health 9, suppl., 208–215 (1987).

    CAS  Google Scholar 

  18. H. W. Lane, D. C. Warren, E. Martin, and J. McCowan,Nutr. Res. 3, 805–817 (1983).

    Article  CAS  Google Scholar 

  19. J. Aaseth, E. Munthe, Ö. Førre, and E. Steinnes,Scand. J. Rheumatol. 7, 237–240 (1978).

    Article  PubMed  CAS  Google Scholar 

  20. H. M. Meltzer, K. Bibow, R. Rønneberg, M. Haugen, and H. Holm, inSelenium in Biology and Medicine, A. Wendel, ed., Springer-Verlag, Heidelberg, 1989, pp. 238–241.

    Google Scholar 

  21. K. Bibow and H. H. Mundal,Clin. Chem. 36, 1902–1905 (1990).

    PubMed  CAS  Google Scholar 

  22. G. Norheim and A. Haugen,Acta Pharmacol. et Toxicol. 59, Suppl. VIII, 610–612 (1986).

    CAS  Google Scholar 

  23. G. Norheim,Proc. Fifth Europ. Conf. Food Chem., Versailles, France, vol.2, 730–734 (1989).

    CAS  Google Scholar 

  24. D. E. Paglia, and W. N. Valentine,J. Lab. Clin. Med. 70, 158–169 (1967).

    PubMed  CAS  Google Scholar 

  25. Norwegian Nutrition CouncilFood Composition Tables. Published by the Norwegian Nutrition Council, Oslo (1984).

    Google Scholar 

  26. J. Kiem,Biol. Trace Element Res. 15, 83–88 (1988).

    CAS  Google Scholar 

  27. Y. X. Wang, and J. Kiem,Biol. Trace Element Res. 15, 89–96 (1988).

    CAS  Google Scholar 

  28. J. Aaseth, H. Frey, E. Glattre, G. Norheim, J. Ringstad, and Y. Thomassen,Biol. Trace Element Res. 24, 147–152 (1990).

    CAS  Google Scholar 

  29. I. S. Palmer, N. Thiex, and O. E. Olson,Nutr. Rep. Int. 27, 249–258 (1983).

    CAS  Google Scholar 

  30. M. Cikrt, A. Mravcova, I. Malatova, and V. Bencko,J. Hyg. Epidemiol. Microbiol. Immunol. 32, 17–29 (1988).

    PubMed  CAS  Google Scholar 

  31. C. Ip and H. Ganther,Carcinogenesis 9, 1481–1484 (1988).

    Article  PubMed  CAS  Google Scholar 

  32. R. J. Kraus and H. E. Ganther,Biol. Trace Element Res. 20, 105–113 (1989).

    Article  CAS  Google Scholar 

  33. K. R. Lowry and D. H. Baker,J. Anim. Sci. 67, 959–965 (1989).

    PubMed  CAS  Google Scholar 

  34. G. Lunde,The Analysis and Characterization of Trace Elements, in Particular Bromine, Selenium and Arsenic in Marine Organisms. Central Institute for Industrial Research, University of Oslo, Ph.D. Thesis (1974).

  35. K. Julshamn. Personal communication. Directorate of Fisheries, Institute of Nutrition, P.O. Box 1900 Nordnes, N-5024 Bergen, Norway (1992).

    Google Scholar 

  36. H. E. Ganther,Selenium in Biology and Medicine. Proc. Third International Symp. Selenium Biol. Med. G. F. Combs, J. E. Spallholz, O. A. Levander, and J. E. Oldfield, eds. AVI, New York: 1987, pp. 53–65.

    Google Scholar 

  37. D. T. Tsay, A. W. Halverson, and I. S. Palmer,Nutr. Reports Int. 2, 203–207 (1970).

    CAS  Google Scholar 

  38. H. Vokal-Borek,Selenium. University of Stockholm, Institute of Physics, November 1979. USIP Report 79-16 (1979).

  39. M. Janghorbani, R. F. Martin, L. J. Kasper, X. F. Sun, and V. R. Young,Am. J. Clin. Nutr. 51, 670–677 (1990).

    PubMed  CAS  Google Scholar 

  40. M. Thorngren and B. Åkesson,Internat. J. Vit. Nutr. Res. 57, 429–435 (1987).

    CAS  Google Scholar 

  41. M. F. Robinson, H. M. Rea, G. M. Friend, R. H. D. Steward, P. C. Snow, and C. D. Thomson,Br. J. Nutr. 39, 589–600 (1978).

    Article  PubMed  CAS  Google Scholar 

  42. R. Bach, U. Schmidt, F. Jung, H. Kiesewetter, B. Hennen, E. Wenzel, H. Schieffer, L. Bette, and S. Heyden,Ann. Nutr. Metabol. 33, 359–367 (1989).

    Article  CAS  Google Scholar 

  43. A. Bjørneboe, A. K. Smith, G.-E. Aa. Bjørneboe, P. O. Thune, and C. A. Drevon,Br. J. Dermatology 118, 77–83 (1988).

    Article  Google Scholar 

  44. K. Bibow,Dietary Intake and Bioavailability of Trace Elements, Especially Selenium. Ph.D. thesis, Department of Chemistry, University of Oslo, Norway (1991).

    Google Scholar 

  45. H. M. Meltzer, G. Norheim, E. B. Løken, and H. Holm,Br. J. Nutr. 67, 287–294 (1992).

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Institute for Nutrition Research University of Oslo, PO Box 1046, N-0316, Oslo, Norway

    Helle M. Meltzer, Irene T. Paulsen & Halvor Holm

  2. Department of Chemistry, University of Oslo, PO Box 1033, N-0315, Oslo, Norway

    Karen Bibow

  3. Department of Internal Medicine, Ullevål Hospital, N-0407, Oslo, Norway

    Håvard H. Mundal

  4. Department of Pharmacology and Toxicology, Norwegian College of Veterinary Medicine/National Veterinary Institute, N-0033, Oslo, Norway

    Gunnar Norheim

Authors
  1. Helle M. Meltzer
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  2. Karen Bibow
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  3. Irene T. Paulsen
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  4. Håvard H. Mundal
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  5. Gunnar Norheim
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  6. Halvor Holm
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Dr. Norheim died on January 9, 1991.

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Meltzer, H.M., Bibow, K., Paulsen, I.T. et al. Different bioavailability in humans of wheat and fish selenium as measured by blood platelet response to increased dietary Se. Biol Trace Elem Res 36, 229–241 (1993). https://doi.org/10.1007/BF02783957

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  • DOI: https://doi.org/10.1007/BF02783957

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